[The formation of a distraction regenerate in the experimental modelling of the shape of the spinal canal]. / Formirovanie distraktsionnogo regenerata pri modelirovanii formy pozvonochnogo kanala v éksperimente.

The process of distractive regenerates of the vertebral arch was studied histologically in mature outbred dogs in modelling of vertebral canal by G. A. Ilizarov technique. During the process of distraction regenerate was shown to have a zonal structure i.e. to include 2 bone regions and connective tissue layering. Its growth is based on the fibers of that layering. The possibility of the increase of vertebral canal sagittal diameter up to 90-100% within 2-2,5 months due to the formation of vertebral arch distractive regenerates is supported by the results of present study and opens the perspective of this technique use in clinical practice.

The use of growth factors to increase the rate of regenerate consolidation.

Two types of growth factors were used in an attempt to improve the quality of the regenerate bone in canine tibias after Ilizarov lengthening. Mechanical testing, biochemical analysis and histology did not demonstrate appreciable differences between the treated and the control limbs.