[Serum concentration and antiviral activity of interferon alpha in chronic hepatitis and liver cirrhosis]. / Kontsentratsiia i protivovirusnaia aktivnost' interferona alfa v syvorotke krovi pri khronicheskom gepatite i tsirroze pecheni.

Blood serum concentration and antiviral activity of IFN-alpha were studied in 121 patients with chronic hepatitis (CH) and in 115 patients with hepatocirrhosis (HC). The increase in IFN-alpha antiviral activity was revealed in 62% CH patients and in 46% HC patients. In CH patients both the mean indices of blood serum IFN-alpha concentration and its antiviral activity increased. The changes were more expressed in CH having viral etiology (HBV and HCV). For the most CH patients with disease positive dynamics the initially high indices of IFN-alpha antiviral activity were typical. In HC patients with portal hypertension syndrome progress and against the background of increased blood serum IFN-alpha concentration its antiviral activity decreases. With development hepatocellular insufficiency, increasing of disease stage (according to the Child-Pugh classification) the decrease in IFN-alpha concentration and its antiviral activity is noted.

[Concentration and antiviral activity of interferon-alpha in the sera of patient with hepatic pathology]. / Kontsentratsiia i protivovirusnaia aktivnost' interferona-alpha v syvorotke krovi bol'nykh s patologiei pecheni.

The normalization of the antiviral activity of interferon-alpha (IFN-alpha) in the process of the treatment of patients with acute viral hepatitis (VH), simultaneously with the results of other clinico-laboratory tests, reflects the positive dynamics of the process. The prolonged preservation of the elevated level of the antiviral activity of IFN-alpha (up to 6 months and longer) is a prognostically unfavorable sign. In patients with chronic VH the growth of both the average concentration of IFN-alpha in the blood serum and its average antiviral activity can be observed. With the progress of the disease and the formation of the cirrhosis of the liver, the concentration of IFN-alpha in the blood serum remains to be elevated, while its antiviral activity drops.

[Diagnostic and prognostic significance of characteristics of serum interferon antiviral activity in chronic and acute diffuse liver diseases]. / Diagnosticheskaia i prognosticheskaia znachimost' pokazatelei protivovirusnoi aktivnosti syvorotochnogo interferona pri khronicheskikh i ostrykh diffuznykh zabolevaniiakh pecheni.

The interferon (IFN-alpha) level and its antiviral activity were investigated in 236 patients, suffered from the chronic diffuse liver disease (CDLD), including 121 patient with chronic hepatitis (CH), 115 patients with hepatocirrhosis (HC) and 26 patients with acute viral hepatitis (AVH). This permitted to elaborate the pathogenetic and prognostic value of these indices in CH, AVH and HC. The analysis of the variations of IFN-alpha antiviral activity in patients with CDLD in dependence on the etiology, activity of the pathologic process, CH stages by CHild-Pugh graduation, the presence of the portal hypertension and its complications was carried out for the first time. The antiviral activity in the patients suffered from HC with progression of the disease, aggravation of the portal hypertension, development of the decompensation along with persisted elevated IFN-alpha concentration decreased. The main mechanisms modulating IFN-alpha antiviral activity in peripheral blood of the patients suffered from CDLD have been determined. The use of the suggested indices in the combination with other methods of the examining significantly extends the possibilities of the diagnostics, permits to evaluate the reserve possibilities of the organism and to detect the strategy of the immunomodulating treatment. The determination of the IFN-alpha antiviral activity in serum in dynamics is recommended for the control of the therapy of the patients with CDLD and AVH.