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Dokl Biochem Biophys ; 481(1): 228-231, 2018 Jul.
Article in English | MEDLINE | ID: mdl-30168067

ABSTRACT

The mechanochemical preparation of solid compositions of praziquantel with plant saponin (glycyrrhizic acid disodium salt) is described. The study of a number of physicochemical parameters showed that dissolving solid compositions in water is accompanied by the inclusion of praziquantel molecules into micelles, which are formed in the solution of the glycyrrhizic acid disodium salt. Using the opisthorchiasis model caused by Opisthorchis felineus, we found a 4- to 11-fold increase in the anthelmintic activity of praziquantel in the composition as compared to the official praziquantel. According to the pharmacokinetic data, the use of the composition increased the bioavailability of praziquantel 3 times.


Subject(s)
Antiplatyhelmintic Agents/chemical synthesis , Antiplatyhelmintic Agents/pharmacology , Glycyrrhizic Acid/chemistry , Mechanical Phenomena , Opisthorchiasis/drug therapy , Praziquantel/chemical synthesis , Praziquantel/pharmacology , Animals , Antiplatyhelmintic Agents/pharmacokinetics , Antiplatyhelmintic Agents/therapeutic use , Biological Availability , Chemical Phenomena , Chemistry Techniques, Synthetic , Cricetinae , Praziquantel/pharmacokinetics , Praziquantel/therapeutic use
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