ABSTRACT
Hemostatic parameters and the diameter of the brachial artery were studied in patients with functional classes II and III angina on exertion before and after an ischemic test. A multivariate statistical analysis was used to determine the significant parameters that distinguish vascular endothelial function in these patients. At the same time it was established that endothelial dysfunction in patients with varying angina pectoris is determined by different predictors of thrombocytic-vascular hemostasis.
Subject(s)
Angina Pectoris/physiopathology , Blood Coagulation , Endothelium, Vascular/physiopathology , Angina Pectoris/blood , Angina Pectoris/drug therapy , Blood Coagulation/drug effects , Blood Coagulation/physiology , Brachial Artery/physiopathology , Case-Control Studies , Endothelium, Vascular/drug effects , Female , Humans , Ischemia/physiopathology , Male , Middle Aged , Platelet Aggregation Inhibitors/administration & dosage , Platelet Aggregation Inhibitors/therapeutic use , Severity of Illness Index , Vasodilator Agents/administration & dosage , Vasodilator Agents/therapeutic useABSTRACT
The study included 30 IHD patients with primary hypercholesterolemia (22 males and 8 females). 18 and 12 patients have received a single daily dose of fluvastatin 20 and 40 mg, respectively, in the evening for 12 weeks. The drug effect was assessed by changes in the clinical status, lipid spectrum, transport-metabolic and absorption-secretory functions of the liver. IHD patients with hypercholesterolemia were found to have dysfunction of the hepatobiliary system. Fluvastatin treatment reduced the level of total cholesterol (Ch), LDLP Ch, triglycerides. HDLP Ch levels remained unchanged. Atherogenic lipoproteins aggregation diminished. Positive changes occurred in hepatic metabolism: bilirubin concentrations lowered, serum albumin went up, absorption-secretory function of hepatocytes normalized, hepatic mono-oxidase system activated. Fluvastatin-related hepatic damage was not reported in the course of 12-month follow-up.
Subject(s)
Anticholesteremic Agents/therapeutic use , Fatty Acids, Monounsaturated/therapeutic use , Indoles/therapeutic use , Liver/drug effects , Myocardial Ischemia/drug therapy , Adult , Aged , Anticholesteremic Agents/adverse effects , Chronic Disease , Drug Evaluation , Fatty Acids, Monounsaturated/adverse effects , Female , Fluvastatin , Humans , Indoles/adverse effects , Lipids/blood , Liver/diagnostic imaging , Liver/physiopathology , Male , Middle Aged , Myocardial Ischemia/blood , Myocardial Ischemia/diagnosis , Myocardial Ischemia/physiopathology , Radionuclide Imaging , Time Factors , UltrasonographyABSTRACT
The authors discuss the results of the diagnosis and treatment of abscesses of the right hepatic lobe which were consequent upon ischemic necrosis; they were encountered after cholecystectomy in 0.15% of cases. Ultrasonography and angiography are the main diagnostic methods suggested. The optimal results of treatment were produces in combination of percutaneous drainage and puncture of the destruction cavities under control of ultrasonography and endovascular regional infusion therapy.
