Influence of SARS-CoV-2 on Adult Human Neurogenesis.

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with the onset of neurological and psychiatric symptoms during and after the acute phase of illness. Inflammation and hypoxia induced by SARS-CoV-2 affect brain regions essential for fine motor function, learning, memory, and emotional responses. The mechanisms of these central nervous system symptoms remain largely unknown. While looking for the causes of neurological deficits, we conducted a study on how SARS-CoV-2 affects neurogenesis. In this study, we compared a control group with a group of patients diagnosed with COVID-19. Analysis of the expression of neurogenesis markers showed a decrease in the density of neuronal progenitor cells and newborn neurons in the SARS-CoV-2 group. Analysis of COVID-19 patients revealed increased microglial activation compared with the control group. The unfavorable effect of the inflammatory process in the brain associated with COVID-19 disease increases the concentration of cytokines that negatively affect adult human neurogenesis.

Unusual case of suicide - hanging in a car using two nooses

Suicide behind the steering wheel of a car is a relatively rare discovery, particularly if the cause of death is hanging. Therefore, such events give rise to suspicions that third parties were involved. This paper presents a case of hanging on the threshold of a car door, although what was taken into consideration during the investigation was suicide, death as a result of a road accident, accidental hanging on the seat belt, and even homicide. The cause of death was determined thanks to a very thorough autopsy which also involved the dissection of extremities and was complemented by additional examinations including toxicological tests. In addition to the medicolegal opinion the Prosecutor's Office took into consideration the opinions of other experts, including experts on the reconstruction of road accidents, and questioned witnesses from the closest social environment of the deceased, as well as strangers. The presented study underlines the significance of conducting a thorough autopsy and the necessity of corroboration of autopsy results with other investigation findings.