Quantification of methane and carbon dioxide surface emissions from a metropolitan landfill based on quasi-continuous eddy covariance measurement.

The Sudokwon landfill (SL) in the Seoul metropolitan area, South Korea, is among the world's largest landfills, striving to curtail landfill gas (LFG) emissions and achieve carbon neutrality by 2050. Since 2005, the SL Management Corporation (SLC) has measured LFG emissions (i.e., methane (CH4) and carbon dioxide (CO2)) using a dynamic flux chamber proposed by the US EPA. However, uncertainty prevails in validating the reduction of LFG emissions due to the limited spatiotemporal data coverage. In 2020, an eddy covariance (EC) system was installed to enhance measurements, revealing highly fluctuating LFG emissions driven by waste layer LFG production, LFG collection, and atmospheric pressure changes. During the study period, the annual CH4 emission increased slightly from 465.0 ± 4.2 to 485.5 ± 6.4 g C m-2, while that of CO2 decreased by 2/3 (from 408.7 ± 16.5 to 270.6 ± 18.8 g C m-2), primarily due to the doubled CO2 uptake by the vegetated topsoil. Our first long-term (March 2020 to February 2022) quasi-continuous monitoring using EC (with a gap-filling and partitioning technique based on Random Forest) emphasizes the difficulty of temporal upscaling of discontinuously observed surface emissions to quantify the LFG inventory and the need for continuous observations or suitable proxies (e.g., atmospheric CH4 concentration).

Size-dependent variation in leaf functional traits and nitrogen allocation trade-offs in Robinia pseudoacacia and Cornus controversa.

Tree species vary in how they invest resources to different functions throughout their life histories, and investigating the detailed patterns of ontogenetic changes in key functional traits will aid in predicting forest dynamics and ecosystem processes. In this context, we investigated size-dependent changes in key leaf functional traits and nitrogen (N) allocation trade-offs in black locust (Robinia pseudoacacia L., an N-fixing pioneer species) and giant dogwood (Cornus controversa Hemsl., a mid-successional species), which have different life-history strategies, especially in their light use. We found that the leaf mass per area and leaf carbon concentrations increased linearly with tree size (diameter at breast height, DBH), whereas leaf N concentrations decreased nonlinearly, with U- and hump-shaped patterns in black locust and giant dogwood, respectively. We also discovered large differences in N allocation between the two species. The fraction of leaf N invested in cell walls was much higher in black locust than in giant dogwood, while the opposite was true for the light harvesting N fraction. Furthermore, these fractions were related to DBH to varying degrees: the cell wall N fraction increased with DBH for both species, whereas the light harvesting N fraction of giant dogwood decreased nonlinearly and that of black locust remained constant. Instead, black locust reduced the fraction of leaf N invested in other N pools, resulting in a smaller fraction compared to that of giant dogwood. On the other hand, both species had similar fraction of leaf N invested in ribulose-1,5-bisphosphate carboxylase/oxygenase across tree size. This study indicated that both species increased leaf mechanical toughness through characteristic changes in N allocation trade-offs over the lifetimes of the trees.

Synthesis of 10-substituted triazolyl artemisinins possessing anticancer activity via Huisgen 1,3-dipolar cylcoaddition.

Most of the 10-substituted triazolylartemisinin synthesized via the Huisgen 1,3-dipolar cylcoaddition of diastereomeric 10-azidoartemisinin (5, 6, and 7) with various alkynes (a-h) exhibit strong growth inhibition activity, even at sub-micromolar concentrations, against various cancer cell lines such as DLD-1, U-87, Hela, SiHa, A172, and B16. In particular, 10b and 10f showed a highly strong cytotoxicity.

Selective vasodilatation effect of sargahydroquinoic acid, an active constituent of Sargassum micracanthum, on the basilar arteries of rabbits.

Sargahydroquinoic acid (2), a major active constituent of Sargassum micracanthum collected from the coast of the East Sea in Korea, showed a selective vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with sargahydroquinoic acid may selectively accelerate cerebral blood flow through dilatation of the basilar artery without lowering systemic blood pressure.

Synthesis of curcumin mimics with multidrug resistance reversal activities.

In order to discover novel multidrug resistance (MDR) reversal agents for efficient cancer chemotherapy, the unsymmetrical curcumin mimics with various amide moieties (6-19) were synthesized and evaluated their MDR reversal activities in MDR cell line KBV20C. Among the tested compounds, 13, 16, and 17 showed potent MDR reversal activities by inhibiting drug efflux function of P-glycoprotein in KB20C cells, and almost recovered the cytotoxicity of vincristine and paclitaxel against KBV20C cell to the degree of potency against drug sensitive KB cells.