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1.
J Travel Med ; 23(2): tav030, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26883926

ABSTRACT

A 20-year-old male soldier was hit by the jellyfish. The ophthalmic examination revealed that epithelial keratitis and corneal oedema in the right eye. We prescribed 3% NaCl eyedrops and 0.3% Norfloxacin eyedrops in the treatment of the corneal jellyfish stings. Two weeks later, the cornea in the right eye healed. In this case report, 3% NaCl eyedrops was effective in the treatment of acute phase of jellyfish stings of the cornea.


Subject(s)
Bites and Stings/diagnosis , Corneal Injuries/diagnosis , Ophthalmic Solutions/therapeutic use , Saline Solution, Hypertonic/therapeutic use , Scyphozoa , Animals , Arm , Bites and Stings/drug therapy , Corneal Injuries/drug therapy , Diagnosis, Differential , Humans , Male , Military Medicine , Military Personnel , Ophthalmic Solutions/administration & dosage , Saline Solution, Hypertonic/administration & dosage , Young Adult
2.
J Pharm Pharmacol ; 68(2): 257-63, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26749510

ABSTRACT

OBJECTIVES: Neutrophil infiltration into the lung is the critical characteristic of acute lung injury (ALI), which is a clinical state with acute inflammatory syndrome. Up to now, there is no effective medicine for ALI. Wogonin has been shown to posses serval biological activities including anti-inflammation, anti-oxidant and anti-carcinoma. METHODS: Acute lung injury was induced by intratracheal injection of LPS, and wogonin at various concentrations was injected intraperitoneally 30 min prior to LPS. Contents of myeloperoxidase (MPO) and expression of chemokines and adhesion molecules were determined by commercially and ELISA assay kits, respectively. Akt phosphorylation and RhoA activation were measured by western blot and RhoA pull-down activation assay, respectively. KEY FINDING: Neutrophil infiltration was reduced by wogonin in a concentration-dependent manner in the LPS-induced ALI mice model. LPS-induced proinflammatory cytokines and adhesion molecules were inhibited by wogonin in bronchoalveolar lavage fluid (BALF) with LPS-induced ALI. Furthermore, wogonin suppressed Akt phosphorylation and RhoA activation in lungs in LPS-induced ALI. The similar parallel trend was observed as wogonin reduced LPS-induced neutrophils infiltration, proinflammatory cytokines generation, adhesion molecules expression, Akt phosphorylation, and RhoA activation. SUMMARY: These results suggested that the effects of wogonin in LPS-induced ALI were induced by inhibition of Akt phosphorylation and RhoA activation.


Subject(s)
Acute Lung Injury/prevention & control , Drugs, Chinese Herbal/therapeutic use , Flavanones/therapeutic use , Lipopolysaccharides/toxicity , Proto-Oncogene Proteins c-akt/metabolism , rho GTP-Binding Proteins/metabolism , Acute Lung Injury/chemically induced , Acute Lung Injury/immunology , Acute Lung Injury/metabolism , Animals , Drugs, Chinese Herbal/administration & dosage , Flavanones/administration & dosage , Intercellular Adhesion Molecule-1/metabolism , Male , Mice, Inbred ICR , Phosphorylation , Scutellaria/chemistry , Vascular Cell Adhesion Molecule-1/metabolism , rhoA GTP-Binding Protein
3.
Hum Exp Toxicol ; 35(9): 1005-15, 2016 Sep.
Article in English | MEDLINE | ID: mdl-26612555

ABSTRACT

Secondhand smoke (SHS) is an important health issue worldwide. Inhaling SHS during pregnancy could cause abnormalities in the internal tissues of newborns, which may then impair fetal development and even cause severe intrauterine damage and perinatal death. However, the understanding of cytopathic mechanisms of SHS by maternal passive smoking on fetus liver during pregnancy is still limited. This study analyzed the effects of high-dose SHS (SHSH) on fetus liver using a maternal passive smoking animal model. Experiments showed that hepatic matrix metalloproteinase-9 activity and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling-positive cells were significantly increased in livers from fetuses of hamsters treated with SHSH. Similarly, expressions of both extrinsic and intrinsic apoptotic molecules were significantly higher in livers from fetuses of hamsters exposed to SHSH. Additionally, significantly increased inflammatory proteins, including transforming growth factor ß, inducible nitric oxide synthase, and interleukin 1ß, and fibrotic signaling molecules, including phosphorylated Smad2/3, SP1, and α-smooth muscle actin, were observed in the fetus livers from hamsters treated with SHSH. This study revealed that SHSH not only increased apoptosis through intrinsic and extrinsic pathways in the livers of fetuses from hamsters exposed to SHSH but also augmented hepatic fibrosis via Smad2/3 signaling.


Subject(s)
Apoptosis/drug effects , Liver/drug effects , Liver/pathology , Prenatal Exposure Delayed Effects/pathology , Tobacco Smoke Pollution/adverse effects , Animals , Apoptosis Regulatory Proteins/metabolism , Cricetinae , Female , Fibrosis , In Situ Nick-End Labeling , Liver/embryology , Liver/immunology , Matrix Metalloproteinase 9/metabolism , Pregnancy , Prenatal Exposure Delayed Effects/immunology , Prenatal Exposure Delayed Effects/metabolism , Smad2 Protein/metabolism , Smad3 Protein/metabolism
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