1.
Mol Cells
; 42(1): 96, 2019 Jan 31.
Article
in English
| MEDLINE
| ID: mdl-30622232
ABSTRACT
[This corrects the article on p. 439 in vol. 39.].
2.
Mol Cells
; 39(6): 439-46, 2016 Jun 30.
Article
in English
| MEDLINE
| ID: mdl-27239813
ABSTRACT
Clearing and labeling techniques for large-scale biological tissues enable simultaneous extraction of molecular and structural information with minimal disassembly of the sample, facilitating the integration of molecular, cellular and systems biology across different scales. Recent years have witnessed an explosive increase in the number of such methods and their applications, reflecting heightened interest in organ-wide clearing and labeling across many fields of biology and medicine. In this review, we provide an overview and comparison of existing clearing and labeling techniques and discuss challenges and opportunities in the investigations of large-scale biological systems.