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1.
Opt Express ; 21(20): 23896-906, 2013 Oct 07.
Article in English | MEDLINE | ID: mdl-24104300

ABSTRACT

We propose a simple, full-range carrier frequency offset (CFO) algorithm for coherent optical orthogonal frequency division multiplexing (CO-OFDM) systems. By applying the Chinese remainder theorem (CRT) to training symbol of single frequency, the proposed CFO algorithm has wide range with shorter training symbol. We numerically and experimentally demonstrate the performance of CRT-based algorithms in a 16-ary quadrature amplitude modulation (QAM) CO-OFDM system. The results show that the estimation range of the CRT-based algorithm is full-range corresponding to the sampling frequency. Also, the bit error ratio (BER) degradation of the proposed algorithm with one training symbol is negligible. These results indicate that the proposed algorithm can be used as a wide range CFO estimator with an increased data rate in high speed CO-OFDM systems.

2.
Lab Anim Res ; 28(2): 109-14, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22787484

ABSTRACT

Altered expression of neurotrophic factors as well as neuroinflammation is commonly associated with Major depressive disorder (MDD) and Alzheimer's disease (AD). To investigate whether or not reserpine-induced MDD affects the expression of AD-related proteins, the expression of γ-secretase components and substrate were measured in brains of ICR mice following reserpine treatment for 15 days. In active avoidance test, total response time and peak slightly increased in the 2 mg/kg reserpine (RSP2)-treated group compared to vehicle-treated group (P<0.05). Expression and phosphorylation of MKP-1, which is a key factor in MDD pathology, were both higher in the RSP2-treated group than the vehicle- and 1 mg/kg reserpine (RSP1)-treated groups (P<0.02). Furthermore, full-length expression of amyloid precursor protein (APP) was enhanced in the RSP1 and RSP2-treated groups compared to the vehicle-treated group, whereas expression of γ-secretase components decreased (P<0.03). Among the three components of the γ-secretase complex, nicastrin protein underwent the largest decrease in expression, as detected by Western blotting (P<0.03). Therefore, the data presented here provide additional evidence about the pathological correlation between MDD and AD.

3.
Lab Anim Res ; 27(4): 293-9, 2011 Dec.
Article in English | MEDLINE | ID: mdl-22232637

ABSTRACT

Peroxiredoxin I (Prx I) is a member of the peroxiredoxins (Prxs) family, which are antioxidant enzymes that regulate various cellular process via intracellular oxidative signal pathways. In order to investigate the correlation between Prx I and the γ-secretase complex, which causes Alzheimer's disease (AD), the expression level of Prx I was firstly evaluated in an animal model for AD. NSE/hPen-2 transgenic (Tg) mice, which were used as animal model in this study, showed a high level of Pen-2 expression and accumulation of Aß-42 peptides in the hippocampus of brain. The expression level of Prx I was significantly higher on the mRNA and protein level in the brain of this model, while not change in Prx VI expression was observed. Furthermore, to verify the effect of Prx I on the γ-secretase components in vitro, the expression level of these components was analyzed in the Prx I transfectants. Of the components of the γ-secretase complex, the expression of PS-2 and Pen-2 was lower in the transfectants overexpressing Prx I compared to the vector transfectants. However, the expression of APP, NCT and APH-1 did not change in Prx I transfectants. Therefore, these results suggested that the expression of Prx I may be induced by the accumulation of Aß-42 peptides and the overexpression of Prx I in neuroblastoma cells may regulate the expression of γ-secretase components.

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