Factors Affecting Well-Being in Korean Young Adults Facing Material Deprivation: Testing the Reserve Capacity Model.

Based on the reserve capacity model, the current study aims to explore the effect of material deprivation on well-being in Korean young adults using path analysis to investigate the mediating effects of loneliness, relationship satisfaction, perceived social support, and depression. Data from 2,041 young adults in the 2021 Youth Socio-Economic Reality Survey were included in a secondary analysis. According to the constructed path model, material deprivation, relationship satisfaction, perceived social support, and depression had significant direct effects on well-being. The indirect effect of material deprivation on well-being was statistically significant and sequentially mediated by loneliness, relationship satisfaction, and depression. Findings suggest the multidimensional effects of material deprivation on the mental health and well-being of Korean young adults through loneliness and relationship satisfaction-representing intrapersonal and interpersonal reserves, respectively. Policy support and multidimensional practical programs are needed to help materially deprived young adults build and maintain relationships and avoid feelings of loneliness and social isolation. [Journal of Psychosocial Nursing and Mental Health Services, 62(3), 29-38.].

[The Effect of Socioeconomic Status to Depression of Perimenopause Women: Pathway Analysis Using the Reserve Capacity Model].

PURPOSE: Based on the Reserve Capacity Model, this study investigated the effects of pre- and postmenopausal women's socioeconomic status (SES) on depression, focusing on the mediating effects of self-esteem, happiness, and family relationship satisfaction with social network relationships. METHODS: This cross-sectional study involved secondary analysis of national data on 771 perimenopause women gathered from the 16th Korea Welfare Panel Study (KOWEPS) 2021. A path analysis model was constructed to evaluate the relationship between SES, social network satisfaction, self-esteem, perceived health status, and depression. Data were analyzed using ADANCO 2.3.1 and Mplus 8.4. RESULTS: Although SES had no direct effect on depression, it did affect depression through self-esteem, happiness, and satisfaction with family relationships. CONCLUSION: The findings of this study indicate that perimenopausal women's personal resources-psychosocial variables such as self-esteem and happiness-had a higher effect on depression than tangible reserves like SES. Therefore, interventions for enhancing self-esteem and happiness may prevent depression in perimenopausal women effectively.

Factors Affecting COVID-19 Preventive Behaviors of Young Adults based on eHealth Literacy and the Health Belief Model: A Cross-Sectional Study.

Following the COVID-19 pandemic, disease prevention and preventive behaviors have become crucial for public health. In young adults, the internet is a popular source of health information. However, research that explores the factors associated with disease preventive behaviors based on the eHealth literacy (eHL) and the Health Belief Model (HBM) in young adults is lacking. A cross-sectional study design was used. Snowball sampling was used to recruit the participants through social network services. Proportionate stratified sampling was applied according to age, sex, and education level to mitigate sampling bias. The URL link for the online survey was provided via their mobile phones. A total of 324 participants, aged 20 to 39, completed the structured questionnaires (response rate = 98.2%). Frequency and descriptive statistical analyses, independent t-tests, one-way analyses of variance, Pearson's correlation coefficients, and multiple linear regression analyses were performed. Factors associated with COVID-19 preventive behaviors were COVID-19-related eHL (ß = .376, P < .001) and self-efficacy (ß = .221, P < .001), which were positively associated with COVID-19 preventive behaviors. Boosting self-efficacy and the ability to find, evaluate, and apply health information with sufficient evidence from the Internet can improve COVID-19 preventive behaviors. The government and healthcare personnel should consider psychological factors such as self-efficacy when developing COVID-19 disease prevention behavioral guidelines for the Internet.

Factors Affecting Depression in Middle-Aged and Elderly Men Living Alone: A Cross-Sectional Path Analysis Model.

The main objectives of this cross-sectional study were to determine the relationship between socioeconomic status (SES) and depression and to estimate the mediating effects of social network satisfaction, self-esteem, and perceived health status among middle-aged and elderly men living alone, based on the reserve capacity model. Secondary data from a sample of 394 middle-aged and elderly men aged 45 years or older from the 15th Korea Welfare Panel Study (KOWEPS) were analyzed. A path analysis model was constructed to evaluate the relationship among SES, social network satisfaction, self-esteem, perceived health status, and depression. The path analysis exhibited significant direct effects of social network satisfaction, self-esteem, and perceived health status on depression and significant indirect effects of SES on depression. There was no direct effect of SES on depression. Social network satisfaction and self-esteem had significant mediating effects of SES on depression. Among middle-aged and elderly men, intrapersonal reserves, which are psychosocial factors including social network satisfaction, self-esteem, and perceived health status, showed more association with depression than tangible reserves such as SES. This suggests that interventions promoting self-esteem and perceived health status could prevent depression.

Hospital Nurses' Willingness to Respond in a Disaster.

OBJECTIVE: This study examined the factors associated with nurses' willingness to respond in a disaster. BACKGROUND: Nurses are key personnel in case of disasters, and therefore, understanding factors associated with willingness to respond is important. METHODS: Questionnaires were distributed to 200 nurses recruited from 2 public hospitals in Seoul, Korea. Data were collected in January and February 2018 and 181 responses were analyzed. RESULTS: Factors predicting willingness to respond in a disaster among public hospital nurses were level of education, self-efficacy, and disaster management competency. CONCLUSIONS: Providing well-organized disaster preparedness and response training programs would enhance nurses' level of knowledge about disasters. In addition, training could improve nurses' self-efficacy and disaster management competency, which should enhance willingness to respond in a disaster.

Structural and dynamic insights into the subtype-specific IP3-binding mechanism of the IP3 receptor.

There are three subtypes of vertebrate inositol 1,4,5-trisphosphate (IP3) receptor (IP3R), a Ca2+-release channel on the ER membrane - IP3R1, IP3R2, and IP3R3 - each of which has a distinctive role in disease development. To determine the subtype-specific IP3-binding mechanism, we compared the thermodynamics, thermal stability, and conformational dynamics between the N-terminal regions of IP3R1 (IP3R1-NT) and IP3R3 (IP3R3-NT) by performing circular dichroism (CD), isothermal titration calorimetry (ITC), and hydrogen-deuterium exchange mass spectrometry (HDX-MS). Previously determined crystal structures of IP3R1-NT and HDX-MS results from this study revealed that both IP3R1 and IP3R3 adopt a similar IP3-binding mechanism. However, several regions, including the α- and ß-interfaces, of IP3R1-NT and IP3R3-NT show significantly different conformational dynamics upon IP3 binding, which may explain the different IP3-binding affinities between the subtypes. The importance of the interfaces for subtype-specific IP3 binding is also supported by the different dynamic conformations of the two subtypes in the apo-states. Furthermore, IP3R1-NT and IP3R3-NT show different IP3-binding affinities and thermal stabilities, but share similar thermodynamic properties for IP3 binding. These results collectively provide new insights into the mechanism underlying IP3 binding to IP3Rs and the subtype-specific regulatory mechanism.

Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin.

The vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily. The VDR binds to active vitamin D3 metabolites, which stimulates downstream transduction signaling involved in various physiological activities such as calcium homeostasis, bone mineralization, and cell differentiation. Quercetin is a widely distributed flavonoidin nature that is known to enhance transactivation of VDR target genes. However, the detailed molecular mechanism underlying VDR activation by quercetin is not well understood. We firstdemonstrated the interaction between quercetin and the VDR at the molecular level by using fluorecence quenching and saturation transfer difference (STD) NMR experiments. The dissociation constant (Kd) of quercetin and the VDR was 21.15 ± 4.31 µM, and the mapping of quercetin subsites for VDR binding was performed using STD-NMR. The binding mode of quercetin was investigated by a docking study combined with molecular dynamics (MD) simulation. Quercetin might serve as a scaffold for the development of VDR modulators with selective biological activities.