Effects of High-Intensity Interval Training Protocols on Liver Enzymes and Wellness in Women.

BACKGROUND: Single-modality, high-intensity interval training (HIIT) using traditional cardiorespiratory exercise selection has been found to provide similar and sometimes superior cardiometabolic effects compared with moderate-intensity continuous training. However, little is known regarding the cardiometabolic and psychosocial effects of HIIT using resistance training modalities. Therefore, this study aims to compare the effects of HIIT using rowing (R-HIIT) and multimodal HIIT (MM-HIIT) using resistance training on liver enzymes, cardiometabolic risk factors, and psychosocial outcomes. METHOD: Recreationally active females with a body mass index <30 kg/m2 (N = 16, 23.0 ± 5.9 years) were randomized into a MM-HIIT or R-HIIT group and completed a 12-week HIIT intervention (ClinicalTrials.gov registration number: https://clinicaltrials.gov/ct2/show/NCT03093441) using principles of social cognitive theory (SCT). Participants completed pre- and postintervention measurements on anthropometrics, resting heart rate, blood pressure, blood measures (lipids, liver enzymes, and glucose), exercise self-efficacy, and perceived wellness. Analysis of covariance was used to examine differences in postintervention measures between groups after controlling for baseline values, waist circumference, and waist-to-height ratio. RESULTS: R-HIIT group had significantly decreased alanine aminotransferase (mean difference = 13.16, P=0.013, effect size (ES) = 0.44, confidence interval (CI) = 3.40 to 22.92) and aspartate aminotransferase (mean difference = 10.79, P=0.024, ES = 0.38, CI = 1.67 to 19.90) levels compared with the M-HIIT group, and the whole group had improved wellness scores (14.72 ± 2.6 to 16.89 ± 2.76, P=0.002). CONCLUSION: R-HIIT may be an effective preventative method for improving liver health in females without obesity. When using principles of SCT, HIIT may enhance overall well-being.

Elevation of hepatic autophagy and antioxidative capacity by endurance exercise is associated with suppression of apoptosis in mice.

INTRODUCTION AND OBJECTIVES: Endurance exercise (EXE) has emerged as a potent inducer of autophagy essential in maintaining cellular homeostasis in various tissues; however, the functional significance and molecular mechanisms of EXE-induced autophagy in the liver remain unclear. Thus, the aim of this study is to examine the signaling nexus of hepatic autophagy pathways occurring during acute EXE and a potential crosstalk between autophagy and apoptosis. MATERIALS AND METHODS: C57BL/6 male mice were randomly assigned to sedentary control group (CON, n=9) and endurance exercise (EXE, n=9). Mice assigned to EXE were gradually acclimated to treadmill running and ran for 60min per day for five consecutive days. RESULTS: Our data showed that EXE promoted hepatic autophagy via activation of canonical autophagy signaling pathways via mediating microtubule-associated protein B-light chain 3 II (LC3-II), autophagy protein 7 (ATG7), phosphorylated adenosine mono phosphate-activated protein kinase (p-AMPK), CATHEPSIN L, lysosome-associated membrane protein 2 (LAMP2), and a reduction in p62. Interestingly, this autophagy promotion concurred with enhanced anabolic activation via AKT-mammalian target of rapamycin (mTOR)-p70S6K signaling cascade and enhanced antioxidant capacity such as copper zinc superoxide dismutase (CuZnSOD), glutathione peroxidase (GPX), and peroxiredoxin 3 (PRX3), known to be as antagonists of autophagy. Moreover, exercise-induced autophagy was inversely related to apoptosis in the liver. CONCLUSIONS: Our findings indicate that improved autophagy and antioxidant capacity, and potentiated anabolic signaling may be a potent non-pharmacological therapeutic strategy against diverse liver diseases.

The Impact of Different High-Intensity Interval Training Protocols on Body Composition and Physical Fitness in Healthy Young Adult Females.

Although traditional high-intensity interval training (HIIT) has been effective in improving body composition and physical fitness, it is unclear how multimodal HIIT affects these variables. This study compared the differences between these two training programs on body composition and physical fitness in apparently healthy, nonobese young adult females. A total of 16 participants (mean age = 23 ± 5.08 years) completed a 12-week HIIT intervention with two treatment groups: rowing and multimodal. Immediately before and after the intervention, the following measures were assessed: body mass index (BMI), total body mass, waist circumference, waist-to-height ratio, total body fat %, visceral adipose tissue, lean mass, bone mineral outcomes, cardiovascular fitness, and muscular fitness. A general linear model with repeated measures was used to assess changes over time for the group as a whole, as well as between-group differences. For the group as a whole, there were significant decrease in total body fat % (p = 0.04) and significant increases in BMI (p = 0.015), total body mass (p = 0.003), lean mass (p < 0.001), bone mineral content (BMC) (p < 0.001), VO2max (p = 0.01), broad jump (p = 0.001), squat endurance (p = 0.006), press (p < 0.001), back squat (p < 0.001), and deadlift (p < 0.001) one repetition maximum (1RM). The multimodal group (p < 0.001) increased deadlift 1RM significantly more than the rowing group (p = 0.002). HIIT can be an effective means for improving cardiovascular and muscular fitness, increasing lean mass and BMC, and thereby improving cardiometabolic as well as musculoskeletal health in nonobese females. Using a multimodal approach may give the added benefit of superior muscular strength increases.