A risk-induced dispersal strategy of the infected population for a disease-free state in the SIS epidemic model.

This article proposes a dispersal strategy for infected individuals in a spatial susceptible-infected-susceptible (SIS) epidemic model. The presence of spatial heterogeneity and the movement of individuals play crucial roles in determining the persistence and eradication of infectious diseases. To capture these dynamics, we introduce a moving strategy called risk-induced dispersal (RID) for infected individuals in a continuous-time patch model of the SIS epidemic. First, we establish a continuous-time n-patch model and verify that the RID strategy is an effective approach for attaining a disease-free state. This is substantiated through simulations conducted on 7-patch models and analytical results derived from 2-patch models. Second, we extend our analysis by adapting the patch model into a diffusive epidemic model. This extension allows us to explore further the impact of the RID movement strategy on disease transmission and control. We validate our results through simulations, which provide the effects of the RID dispersal strategy.

Predation-induced dispersal toward fitness for predator invasion in predator-prey models.

In this paper, we consider a predator-prey model with nonuniform predator dispersal, called predation-induced dispersal (PID), which represents predator motility depending on the maximal predation rate and the predator death rate in a spatially heterogeneous region. We study the local stability of the semitrivial steady state when predators are absent for models with PID and linear dispersal. We then investigate the local/global bifurcation from the semitrivial steady state of these models. Finally, we compare the results of the model with PID to the results of the model with linear dispersal. We conclude that the nonuniform dispersal of predators obeying PID increases fitness for predator invasion when rare; thus, predators with PID can invade a region with an increased probability even in cases wherein predators dispersed linearly cannot invade a certain region. Based on the results, we provide an ecological interpretation with the simulations.

On the Fitness of Predators with Prey-Induced Dispersal in a Habitat with Spatial Heterogeneity.

This study considers a situation in which a predator can change its dispersal rate according to its satisfaction with foraging prey in a predator-prey interaction. However, since it is impossible to accurately determine the magnitude of the density of prey that is favorable to a predator's survival in an area, the predator determines the movement rate through inaccurate judgment. In this situation, we investigate the effect of the predator's decision about its movement on fitness. To achieve our goal, we consider a predator-prey model with nonuniform predator dispersal, called prey-induced dispersal (PYID), in which the spread of predators is small when the prey density is larger than a certain value, and when the prey density is smaller than a particular value, a large spread of predators occurs. To understand how PYID affects the dynamics and coexistence of the system in a spatially heterogeneous region, we examine a model with Holling-type II functional responses under no-flux boundary conditions wherein the predators move according to the PYID. We study the local stability of the semitrivial solution of models with PYID and linear dispersal where the predator is absent. Furthermore, we investigate the local/global bifurcation from the semitrivial solution of models with two different dispersals. We conclude that in most cases, nonuniform dispersal of predators following PYID promotes predator fitness; however, there is a case in which PYID does not increase predator fitness. If a predator's satisfaction degree regarding the prey density is higher than a certain level, there may exist a case that is not beneficial for predators in terms of their fitness. However, if the satisfaction level of predators regarding prey density is relatively low, predators following PYID will take advantage of fitness. More precisely, if predators are dissatisfied with the amount of prey in a region and move quickly, even for abundant prey density, they may not benefit from PYID. Meanwhile, if predators change their motility when they are appropriately satisfied with the amount of prey, they will obtain a survival advantage. We obtain the results by analyzing an eigenvalue problem at the semitrivial solution from the linearized operators derived from the models.

Intestinal anti-inflammatory activity of Ulva ohnoi oil in DSS-induced experimental mouse model.

This study was conducted to examine the physiological activity of Ulva ohnoi, some of which may be used for food or natural products but could disturbing coastal ecosystems due to large scale green-tide, to check values of U. ohnoi oil through experimental results. U. ohnoi oil was extracted from bulk of Ulva biomass to confirm its antioxidant and antibacterial activity, and the efficacy of U. ohnoi oil in the state of inflammation was confirmed through animal experiments. To confirm the anti-inflammatory effect, a mouse model induced with DSS was used. As a result of measuring NO using plasma after induction of inflammation, the amount of NO produced in the U. ohnoi oil group was decreased compared to the control group. Expression of inflammatory cytokines TNF-α, IL-6, and IL-1ß was decreased compared to the control group. As a result of observing H&E staining, lower crypt loss and inflammatory cell infiltration were found in the U. ohnoi oil group compared to the control group. Consequently, U. ohnoi oil appears to have great anti-inflammatory properties.

Local dynamics and coexistence of predator-prey model with directional dispersal of predator.

In this paper, we study the effect of directional dispersal of a predator on a predator- prey model. The prey is assumed to have traits making it undetectable to the predator and difficult to chase the prey directly. Directional dispersal of the predator is described when the predator has learned the high hunting efficiency in certain areas, thereby dispersing toward these areas instead of directly chasing the prey. We investigate the stability of the semi-trivial solution and the existence of a coexistence steady-state. Moreover, we show that the predator that moves toward a high-predation area may make the predators survive under the condition the predators cannot survive when they disperse randomly. The results are obtained through eigenvalue analysis and fixed-point index theory. Finally, we present the numerical simulation and its biological interpretations based on the obtained results.

Intraguild predation with evolutionary dispersal in a spatially heterogeneous environment.

In many cases, the motility of species in a certain region can depend on the conditions of the local habitat, such as the availability of food and other resources for survival. For example, if resources are insufficient, the motility rate of a species is high, as they move in search of food. In this paper, we present intraguild predation (IGP) models with a nonuniform random dispersal, called starvation-driven diffusion, which is affected by the local conditions of habitats in heterogeneous environments. We consider a Lotka-Volterra-type model incorporating such dispersals, to understand how a nonuniform random dispersal affects the fitness of each species in a heterogeneous region. Our conclusion is that a nonuniform dispersal increases the fitness of species in a spatially heterogeneous environment. The results are obtained through an eigenvalue analysis of the semi-trivial steady state solutions for the linearized operator derived from the model with nonuniform random diffusion on IGPrey and IGPredator, respectively. Finally, a simulation and its biological interpretations are presented based on our results.

Microneedle delivery of trivalent influenza vaccine to the skin induces long-term cross-protection.

A painless self-immunization method with effective and broad cross-protection is urgently needed to prevent infections against newly emerging influenza viruses. In this study, we investigated the cross-protection efficacy of trivalent influenza vaccine containing inactivated A/PR/8/34 (H1N1), A/Hong Kong/68 (H3N2) and B/Lee/40 after skin vaccination using microneedle patches coated with this vaccine. Microneedle vaccination of mice in the skin provided 100% protection against lethal challenges with heterologous pandemic strain influenza A/California/04/09, heterogeneous A/Philippines/2/82 and B/Victoria/287 viruses 8 months after boost immunization. Cross-reactive serum IgG antibody responses against heterologous influenza viruses A/California/04/09, A/Philippines/2/82 and B/Victoria/287 were induced at high levels. Hemagglutination inhibition titers were also maintained at high levels against these heterogeneous viruses. Microneedle vaccination induced substantial levels of cross-reactive IgG antibody responses in the lung and cellular immune responses, as well as cross-reactive antibody-secreting plasma cells in the spleen. Viral loads in the lung were significantly (p < 0.05) reduced. All mice survived after viral challenges. These results indicate that skin vaccination with trivalent vaccine using a microneedle array could provide protection against seasonal epidemic or new pandemic strain of influenza viruses.

The characteristics of the expression of heat shock proteins and COX-2 in the liver of hamsters infected with Clonorchis sinensis, and the change of endocrine hormones and cytokines.

The liver fluke Clonorchis sinensis (Digenea) is a high-risk parasite that causes serious diseases such as cirrhosis, carcinogenic liver damage and clonorchiasis in East Asia. This study was conducted to evaluate the relationship between stress/endocrine hormones and inflammation induced by infection as well as the expression of heat shock proteins (hsp-27, hsp-90), cox-2 and cytokines in the livers of hamsters infected with C. sinensis. The average body weight of infected hamsters decreased up to 25% compared with that of the control group, and bile duct hyperplasia with inflammation, liver fibrosis and hepatic necrosis were observed in C. sinensis-infected livers. The expression of hsp-27, hsp-90, and cox-2 was significantly increased in the livers of C. sinensis-infected hamsters compared with the control group. Moreover, the expression levels of inflammatory cytokines (IL-1beta, IL-2, TGF-beta2 and IFN-alpha1) were markedly increased in the livers of the infected group compared with those of the control group. Consistently, plasma IL-3 and IL-6 levels gradually increased during the infection period, and the concentration levels of testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), corticosterone, and adrenocorticotropic hormone (ACTH) in C. sinensis-infected hamsters increased over 25%, compared with those of the uninfected normal group. These results demonstrate that C. sinensis infection may increase the expression of hsp27, hsp90 and cox-2 as well as it may cause periductal fibrosis, chronic inflammation and hepatic necrosis in the liver. Furthermore, the results indicate that C. sinensis infection induces not only stress-induced hormone imbalance but also the sustained secretion of inflammatory cytokines through chronic stress/stimuli.

Effects of fraction obtained from Korean Corni Fructus extracts causing anti-proliferation and p53-dependent apoptosis in A549 lung cancer cells.

Corni Fructus has traditionally been used as herbal medicine for the treatment of tuberculosis, asthma, hepatitis, and chronic nephritis in Korea, Japan, and China. This research was carried out to evaluate the proliferative-inhibitory effect of CF extracts against cancer cells and to identify the new pro-substance from medicinal plants. Among these herbal extracts extracted from KCF (Korean Corni Fructus), JCF (Japanese Corni Fructus) and CCF (Chinese Corni Fructus), KCF extracts strongly induced anti-proliferation of cancer cells in a dose-dependent manner compared with other extracts. Moreover, after treatment with CM/F3 (fraction 3 obtained from KCF extracts) for 24 h, A549 cells were evaluated by several indicators such as cell viability, LDH release, DNA fragmentation, nuclear condensation, and apoptotic proteins in vitro. CM/F3 showed the tumor-selective growth inhibitory activity in a dose- and time-dependent manner in A549 cells. Consistently, CM/F3 effectively induced the activation of bax, cytochrome-c, caspase-3, -8, -9, p53, and p21 causing apoptosis, and caused the suppression of Cdk2, pRb, and E2F1 related to cell arrest in A549 cells. These results demonstrate that CM/F3 caused not only anti-proliferation but also cell death involving cell arrest through interaction between apoptotic proteins and the upregulation of p53 in A549 cells.

Analysis of parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (1984-2005) in Seoul, Korea.

We analyzed parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (KMC) from 1984 to 2005. The total number of parasite infection cases was 150 (0.07%) out of the total 211,859 biopsy specimens submitted for histopathological examinations. They consisted of 62 cysticercosis, 23 sparganosis, 16 paragonimiasis, 15 amebiasis, 11 anisakiasis, 11 clonorchiasis, 3 ascariasis, 2 scabies, 2 enterobiasis, 2 trichuriasis, 1 leishmaniasis, 1 taeniasis, and 1 thelaziasis. Out of 62 cysticercosis cases, 55 were detected in subcutaneous tissues or the central nerve system. Eighteen out of 23 sparganosis cases were involved in muscular and subcutaneous tissues. In most anisakiasis cases, the involved organ was the stomach. The lung and the pleura were the most common site of paragonimiasis. The incidence of parasitic diseases during the first 5 years (1984-1988) was the highest of all observed periods. After 1989, similar incidences were shown throughout the period. Whereas cysticercosis was diagnosed in 34 cases during 1984-1988, no case has been diagnosed since 2000. In the case of sparganosis, the chronological incidence was almost uniform throughout the period 1984-2005. Paragonimiasis showed a similar tendency to cysticercosis. In gender and age distribution of parasitic diseases, men showed higher incidence rates than females, and the age groups of the 40s or older indicated higher infection frequencies than other age groups. Therefore, these results are a significant report to appear the tendency of human parasitic disease diagnosed by tissue biopsy in association with parasitosis at KMC in Seoul.