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Preliminary evaluation of CNS effects of 6-O-substituted chelidonine derivatives.
Jagiello-Wójtowicz, Ewa; Chodkowska, Anna; Gadzikowska, Maria; Chojecka-Koryn, Ewa; Grynkiewicz, Grzegorz.
Acta Pol Pharm ; 60(2): 133-8, 2003.
Article in English | MEDLINE | ID: mdl-13678323

ABSTRACT

Eleven new derivatives of chelidonine I, obtained by functionalization of the alkaloid hydroxyl group, have been tested for CNS activity in mice exhibiting statistically significant effects.


Subject(s)
Alkaloids/chemistry , Alkaloids/pharmacology , Berberine Alkaloids , Central Nervous System/drug effects , Phenanthridines , Animals , Benzophenanthridines , Central Nervous System/physiology , Drug Evaluation, Preclinical/methods , Male , Mice
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