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1.

[Comparison of spectrophotometric and colorimetric methods in determination of clavulanic acid]. / Porównawcze oznaczanie kwasu klawulanowego metoda hydroksyloaminowa i spektrofotometryczna.

Pajchel, G; Borowiecka, B; Chojnowski, W.

Acta Pol Pharm ; 49(3): 17-21, 1992.

Article in Polish | MEDLINE | ID: mdl-16092406

ABSTRACT

The spectrophotometric method for determination of clavulanic acid and amoxycillin after NaOH hydrolysis was elaborated.

Subject(s)

Amoxicillin/analysis , Clavulanic Acid/analysis , Colorimetry , Spectrophotometry , Anti-Bacterial Agents/analysis , Colorimetry/methods , Drug Combinations , Hydrolysis , Spectrophotometry/methods

2.

[Determination of moxalactam, aztreonam and imipenem by the perchloric hydroxylamine method]. / Oznaczanie moksalaktamu, aztreonamu i imipenemu metoda hydroksyloaminowo-nadchloranowa.

Pajchel, G; Borowiecka, B; Chojnowski, W.

Acta Pol Pharm ; 49(1-2): 7-10, 1992.

Article in Polish | MEDLINE | ID: mdl-8769073

ABSTRACT

The reaction of perchloric hydroxylamine was adopted for determination of new beta-lactam antibiotics within monobactam, carbapenem and oxazepam groups. Complexes formed in colour reaction are stable over 2 hours in the case of aztreonam and imipenem, and over 1 hour for moxalactam, statistical analysis proved that both hydroxylamine-perchloric and spectrophotometric methods can be used alternatively.

Subject(s)

Anti-Bacterial Agents/analysis , Aztreonam/analysis , Hydroxylamines/chemistry , Imipenem/analysis , Moxalactam/analysis , Anti-Bacterial Agents/chemistry , Aztreonam/chemistry , Drug Stability , Hydroxylamine , Imipenem/chemistry , Moxalactam/chemistry

3.

[Cefamandole- and cefoxitin-produced changes in drug sensitivity of Escherichia coli]. / Zmiany wrazliwosci Escherichia coli wywolane cefamandolem i cefoksytyna.

Jastalska, D; Lupicki, W; Zapasnik, M; Pajchel, G; Chojnowski, W.

Pol Tyg Lek ; 43(49): 1576-9, 1988 Dec 05.

Article in Polish | MEDLINE | ID: mdl-3076651

Subject(s)

Cefamandole/pharmacology , Cefoxitin/pharmacology , Escherichia coli/drug effects , Culture Media , Drug Resistance, Microbial , In Vitro Techniques , Microbial Sensitivity Tests

4.

[Changes in the sensitivity of clinical strains of Staphylococcus aureus caused by cefamandole, cefoperazone and 6-alpha-bromopenicillanic acid sulfone in vitro]. / Zmiany wrazliwosci klinicznych szczepów Staphylococcus aureus wywolane cefamandolem, cefoperazonem i sulfonem kwasu 6-alfa-bromopenicylanowego in vitro.

Jastalska, D; Lupicki, W; Zapasnik, M; Pajchel, G; Chojnowski, W.

Pol Tyg Lek ; 42(18): 552-6, 1987 May 04.

Article in Polish | MEDLINE | ID: mdl-2819835

Subject(s)

Cefamandole/pharmacology , Penicillanic Acid/pharmacology , Staphylococcus aureus/drug effects , Cefoperazone/pharmacology , Drug Resistance, Microbial , In Vitro Techniques

5.

[Antibacterial activity of beta-lactamase inhibitors and selected beta-lactam antibiotics]. / Aktywnosc przeciwbakteryjna inhibitorów beta-laktamaz i wybranych antybiotyków beta-laktamowych.

Jastalska, D; Lupicki, W; Pajchel, G; Zapasnik, M; Chojnowski, W.

Pol Tyg Lek ; 41(34): 1071-5, 1986 Aug 25.

Article in Polish | MEDLINE | ID: mdl-3097627

Subject(s)

Anti-Bacterial Agents/pharmacology , Enterobacteriaceae/drug effects , Microbial Sensitivity Tests , Pseudomonas aeruginosa/drug effects , Staphylococcus aureus/drug effects , beta-Lactamase Inhibitors , beta-Lactams

6.

[Synergistic effect of new beta-lactam antibiotics, clavulanic acid and dibekacin on pathogenic microorganisms]. / Synergiczne dzialanie nowych antybiotyków beta-laktamowych, kwasu klawulanowego i dibekacyny na drobnoustroje chorobotwórcze.

Jastalska, D; Lupicki, W; Zapasnik, M; Pajchel, G; Chojnowski, W.

Pol Tyg Lek ; 39(43): 1415-8, 1984 Oct 22.

Article in Polish | MEDLINE | ID: mdl-6440130

Subject(s)

Anti-Bacterial Agents/pharmacology , Clavulanic Acids/pharmacology , Dibekacin/pharmacology , Enterobacteriaceae/drug effects , Kanamycin/analogs & derivatives , Pseudomonas aeruginosa/drug effects , Clavulanic Acid , Drug Resistance, Microbial , Drug Synergism , In Vitro Techniques

7.

[Effect of selected antibiotics on Gram-negative bacteria isolated from the upper respiratory tract of patients with respiratory diseases]. / Dzialanie wybranych antybiotyków na Gram-ujemne paleczki izolowane z górnych dróg oddechowych chorych z chorobami ukladu oddechowego.

Jastalska, D; Gralewicz, J; Lupicki, W; Chojnowski, W.

Pol Tyg Lek ; 37(36): 1041-8, 1982 Sep 27.

Article in Polish | MEDLINE | ID: mdl-7170256

Subject(s)

Anti-Bacterial Agents/pharmacology , Enterobacteriaceae Infections/microbiology , Enterobacteriaceae/drug effects , Respiratory Tract Infections/microbiology , Sputum/microbiology , Adolescent , Adult , Aged , Culture Techniques , Drug Resistance, Microbial , Female , Humans , Male , Microbial Sensitivity Tests , Middle Aged

8.

Chemical modifications in the erythromycin group leading to an increase of the antibacterial activity.

Bojarska-Dahlig, H; Slawinski, W; Chojnowski, W; Dziegielewska, I; Glabski, T; Biedrzycki, M; Naperty, S; Schaeffer, A.

Mater Med Pol ; 14(1-2): 79-84, 1982.

Article in English | MEDLINE | ID: mdl-7186999

Subject(s)

Bacteria/drug effects , Erythromycin/analogs & derivatives , Erythromycin/pharmacology , Structure-Activity Relationship

9.

[Semisynthetic penicillins. XVIII. Studies on the relationship between the structure of the side chain and the antibacterial activity of amidinopenicillins]. / Penicyliny pólsyntetyczne. XVIII. Z badan nad zaleznoscia pomiedzy budowa lancucha bocznego a aktywnoscia przeciwbakteryjna amidynopenicylin.

Jastalska, D; Gralewicz, J; Busko-Oszczapowicz, I; Cieslak, J; Chojnowski, W.

Acta Pol Pharm ; 36(1): 103-9, 1979.

Article in Polish | MEDLINE | ID: mdl-228532

Subject(s)

Ampicillin/pharmacology , Azepines/pharmacology , Caprolactam/pharmacology , Enterobacteriaceae/drug effects , Penicillanic Acid/pharmacology , Pyrrolidinones/pharmacology , Staphylococcus aureus/drug effects , Caprolactam/analogs & derivatives , Chemical Phenomena , Chemistry , Penicillins/pharmacology

10.

[Spectrophotometric and chromatographic studies of amikacin and butyrosine]. / Spektrofotometryczne i chromatograficzne badania amikacyny i butyrozyny.

Borowiecka, B; Chojnowski, W.

Acta Pol Pharm ; 35(4): 471-5, 1978.

Article in Polish | MEDLINE | ID: mdl-81591

Subject(s)

Amikacin/analysis , Anti-Bacterial Agents/analysis , Butirosin Sulfate/analysis , Kanamycin/analogs & derivatives , Chromatography, Thin Layer , Colorimetry

11.

[Quantitative and qualitative aspects of the interaction of antibiotics and proteins. III. Comparative studies on the affinity of various selected cationic and anionic antibiotics to blood serum albumin]. / Ilosciowe i jakosciowe aspekty interakcji antybiotyków z bialkami. III. Porównanie powinowactwa do albuminy wybranych antybiotyków o charakterze kationów i anionów.

Chojnowski, W; Gralewicz, J; Lupicki, W.

Acta Pol Pharm ; 35(3): 365-71, 1978.

Article in Polish | MEDLINE | ID: mdl-696371

Subject(s)

Anti-Bacterial Agents/blood , Serum Albumin/metabolism , Humans , Kinetics , Protein Binding

12.

[Technology of sugar-free protein preparates production for pharmaceutical purposes (author's transl)]. / Opracowanie technologii produkcji bezcukrowych preparatów bialkowych dla celów farmaceutycznych.

Chojnowski, W; Bednarski, W; Poznanski, S; Jakubowski, J; Leman, J.

Przegl Lek ; 35(4-5): 566-8, 1978.

Article in Polish | MEDLINE | ID: mdl-694046

Subject(s)

Dietary Proteins , Dietary Carbohydrates , Food Technology , Humans , Milk Proteins , Poland

13.

[Some biological properties of new antibiotics. II. Comparison of antibacterial activity of some selected beta-lactam and aminoglycoside antibiotics]. / Wlasciwosci biologiczne nowych antybiotyków. II. Porównanie aktywnosci przeciwbakteryjnych wybranych antybiotyków beta-laktamowych i aminoglikozydowych

Chojnowski, W; Gralewicz, J; Jastalska, D; Morris-Rostkowsak, W; Zapasnik, M.

Acta Pol Pharm ; 34(2): 221-6, 1977.

Article in Polish | MEDLINE | ID: mdl-868553

Subject(s)

Aminoglycosides/pharmacology , Bacteria/drug effects , Penicillins/pharmacology , beta-Lactams/pharmacology , Microbial Sensitivity Tests

14.

[Quantitative and qualitative aspects of interactions between antibiotics and proteins. II. Binding strength of rifampicin and novobiocin with serum albumin]. / Ilosciowe i jakosciowe aspekty interakcji antybiotyków z bialkami. II. Badanie sily wiazania ryfampicyny i nowobiocyny z albumina

Chojnowski, W; Gralewicz, J.

Acta Pol Pharm ; 34(2): 227-30, 1977.

Article in Polish | MEDLINE | ID: mdl-868554

Subject(s)

Novobiocin/metabolism , Rifampin/metabolism , Serum Albumin/metabolism , Protein Binding

15.

[Formation of Escherichia coli resistance to amidine penicillin]. / Badanie mechanizmu powstawania opornosci Escherichia coli na dzialanie penicyliny amidynowej

Zapasnik, M; Morris-Rostkowska, W; Chojnowski, W.

Acta Pol Pharm ; 33(5): 663-4, 1976.

Article in Polish | MEDLINE | ID: mdl-187015

Subject(s)

Escherichia coli/drug effects , Penicillanic Acid/pharmacology , Azepines/pharmacology , Drug Resistance, Microbial

16.

[Quantitative and qualitative aspects of the interaction of antibiotics with proteins. I. Binding of rifampicin and novobiocin to human blood albumin]. / Ilosciowe i jakosciowe aspekty interakcji antybiotyków z bialkami. I. Wiazanie ryfampicyny i nowobiocyny z albumina krwi ludzkiej

Chojnowski, W; Gralewicz, J.

Acta Pol Pharm ; 33(2): 235-8, 1976.

Article in Polish | MEDLINE | ID: mdl-937028

Subject(s)

Novobiocin/blood , Rifampin/blood , Serum Albumin/metabolism , Drug Interactions , Humans , Protein Binding

17.

[Biological properties of some new antibacterial antibiotics. I. Activities of some derivatives of 6-aminopenicillanic acid (6-AP) and 7-aminocephallosporanic acid (7-AC)]. / Wlasciwosci biologiczne nowych przeciwbakteryjnych antybiotykow. I. Aktywnosc pochondnych kwasu 6-aminopenicylanowego (6-AP) i 7-aminocefalosporanowego (7-AC)

Jastalska, D; Zapasnik, M; Gralewicz, J; Morris-Rostkowska, W; Chojnowski, W.

Acta Pol Pharm ; 32(6): 709-14, 1975.

Article in Polish | MEDLINE | ID: mdl-174391

Subject(s)

Cephalosporins/pharmacology , Penicillanic Acid/pharmacology , Bacteria/drug effects , Drug Resistance, Microbial

18.

[Antibiotic binding to blood proteins and its significance in therapy]. / Wiazanie antybiotyków z bialkami krwi i jego znaczenie dla terapii.

Chojnowski, W; Gralewicz, J.

Pol Tyg Lek ; 29(28): 1223-5, 1974 Jul 15.

Article in Polish | MEDLINE | ID: mdl-4603113

Subject(s)

Anti-Bacterial Agents/metabolism , Blood Proteins/metabolism , Protein Binding , Age Factors , Anti-Bacterial Agents/blood , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/toxicity , Binding Sites , Binding, Competitive , Half-Life , Humans , Hydrogen-Ion Concentration , Infant, Newborn , Serum Albumin/metabolism

19.

Some aspects of the binding of antibiotics to serum proteins.

Chojnowski, W; Gralewicz, J.

Postepy Hig Med Dosw ; 28(4): 639-47, 1974.

Article in English | MEDLINE | ID: mdl-4415814

Subject(s)

Anti-Bacterial Agents , Blood Proteins , Protein Binding , Kinetics , Serum Albumin

20.

[Antibiotic and blood protein binding and its therapeutic importance]. / Wiazanie antybiotyków z bialkami krwi i jego znaczenie dla terapii

Chojnowski, W; Gralewicz, J.

Pol Tyg Lek ; 29(21): 905-7, 1974 May 27.

Article in Polish | MEDLINE | ID: mdl-4600556

Subject(s)

Anti-Bacterial Agents/metabolism , Blood Proteins/metabolism , Protein Binding , Anti-Bacterial Agents/pharmacology , Drug Interactions , Fusidic Acid/metabolism , Gentamicins/metabolism , Humans , Hydrogen-Ion Concentration , Novobiocin/metabolism , Penicillins/metabolism , Serum Albumin/metabolism , Streptomycin/metabolism , Tetracycline/metabolism

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