Subject(s)
Corpus Luteum/drug effects , Genes, Dominant , Genes, Lethal , Mutation , Animals , Embryo Implantation , Female , Humans , MiceABSTRACT
Male mice (Q strain) received two consecutive injections of organophosphorus insecticides: a phosphonate (trichlorfon) was combined to a thiophosphate (methylparathion) or a dithiophosphate (malathion or methylazinphos) in order to evaluate the interactions at the genetic and cytogenetic levels. No increase in chromosome damage was observed in bone marrow cells, spermatogonia, and primary spermatocytes. In a dominant lethal mutation assay, the frequency of postimplantation lethality was not significantly increased over the control level. The percentage of preimplantation losses was enhanced, probably due to a toxic effect on male germ cells.
Subject(s)
Insecticides/toxicity , Mutagens , Animals , Azinphosmethyl/toxicity , Chromosome Aberrations , Drug Synergism , Female , Malathion/toxicity , Male , Methyl Parathion/toxicity , Mice , Reproduction/drug effects , Spermatozoa/drug effects , Trichlorfon/toxicityABSTRACT
Male mice (Q strain) received 5 days a week for 7 weeks drinking water containing dichlorvos (2 ppm), dimethoate (0.6 ppm), malathion (8 ppm), methylparathion (0.15 ppm), or trichlorfon (0.5 ppm). At the end of the treatment, no chromosome damage was observed in bone marrow cells, spermatogonia, and primary spermatocytes. Dominant lethal mutation assays were performed to investigate the pre- and postimplantation foetal lethality. Only negative results were obtained.
Subject(s)
Insecticides/toxicity , Mutagens , Organophosphorus Compounds , Organothiophosphorus Compounds , Animals , Bone Marrow/ultrastructure , Chromosomes/drug effects , Chromosomes/ultrastructure , Genes, Dominant/drug effects , Genes, Lethal/drug effects , Male , Mice , Mutagenicity Tests , Spermatogonia/ultrastructureABSTRACT
Male mice (Q strain) were given a single ip injection at the maximum tolerated dose of one of four commercial mixtures of insecticides: Luxan Tue-Taons (150 g dimethoate and 150 g fenitrothion/litre), Metadipterex (210 g trichlorfon and 270 g methyldemeton/litre), Dynafos (155 g malathion, 60 g dichlorvos and 75 g carbaryl/litre) and Phosan Plus (95 g dimethoate, 100 g malathion and 100 g methoxychlor/litre). At the maximum tolerated doses, Luxan Tue-Taons (60 mg/kg), Metadipterex (15 mg/kg), Dynafos (50 mg/kg) and Phosan Plus (100 mg/kg) did not induce chromosome aberrations in bone-marrow cells, spermatogonia or primary spermatocytes of the mice. No evidence of potential genetic effects was obtained in a dominant lethal mutation assay.
Subject(s)
Insecticides/toxicity , Mutagens , Animals , Bone Marrow/drug effects , Chromosome Aberrations , Genes, Dominant/drug effects , Genes, Lethal/drug effects , Male , Mice , Mutagenicity Tests , Organophosphorus Compounds , Reproduction/drug effects , Spermatogonia/drug effectsABSTRACT
Male mice (Q strain) received a single i.p. injection of 14 organophosphorus compounds, including 11 insecticides, administered on separate occasions. After a recovery period of 10 to 15 days, the cytogenic effects were analyzed in primary spermatocytes at diakinesis-metaphase I corresponding to the treatment of A4-B type spermatogonia. At the highest tolerated dose, trimethylphosphate (1000 mg/kg), triethylphosphate (300 mg/kg), dichlorvos (10 mg/kg), methylparathion (10 mg/kg), ethylparathion (10 mg/kg), ethylparaoxon (0.3 mg/kg), fenitrothion (1000 mg/kg), methylbromophos (1000 mg/kg), ethylbromophos (1000 mg/kg), dimethoate (10 mg/kg), malathion (300 mg/kg), methylazinphos (1 mg/kg), ethylazinphos (1 mg/kg) and trichlorfon (100 mg/kg) did not produce chromosome damage.
Subject(s)
Chromosomes/drug effects , Insecticides/toxicity , Organophosphorus Compounds/toxicity , Spermatocytes/drug effects , Spermatozoa/drug effects , Animals , Chromosome Aberrations , Male , Mice , Spermatocytes/ultrastructureSubject(s)
Insecticides/toxicity , Mutagens , Organothiophosphates/toxicity , Organothiophosphorus Compounds/toxicity , Animals , Bone Marrow/ultrastructure , Chromosome Aberrations , Female , Male , Mice , Mice, Inbred Strains , Mitomycin , Mitomycins/toxicity , Organophosphates/toxicity , Spermatogonia/ultrastructureABSTRACT
Male mice (Q strain) were injected intraperitoneally with a high dose (i.e., 1 g/kg) of the organophosphorus insecticide Fenitrothion. No increase in the percentage of chromosome aberrations was observed in bone marrow cells and spermatogonia. A dominant lethal mutation assay did not show any enhancement of fetal mortality before or after implantation.
