Cognitive testing of tobacco use items for administration to patients with cancer and cancer survivors in clinical research.

BACKGROUND: To the authors' knowledge, there are currently no standardized measures of tobacco use and secondhand smoke exposure in patients diagnosed with cancer, and this gap hinders the conduct of studies examining the impact of tobacco on cancer treatment outcomes. The objective of the current study was to evaluate and refine questionnaire items proposed by an expert task force to assess tobacco use. METHODS: Trained interviewers conducted cognitive testing with cancer patients aged ≥21 years with a history of tobacco use and a cancer diagnosis of any stage and organ site who were recruited at the National Institutes of Health Clinical Center in Bethesda, Maryland. Iterative rounds of testing and item modification were conducted to identify and resolve cognitive issues (comprehension, memory retrieval, decision/judgment, and response mapping) and instrument navigation issues until no items warranted further significant modification. RESULTS: Thirty participants (6 current cigarette smokers, 1 current cigar smoker, and 23 former cigarette smokers) were enrolled from September 2014 to February 2015. The majority of items functioned well. However, qualitative testing identified wording ambiguities related to cancer diagnosis and treatment trajectory, such as "treatment" and "surgery"; difficulties with lifetime recall; errors in estimating quantities; and difficulties with instrument navigation. Revisions to item wording, format, order, response options, and instructions resulted in a questionnaire that demonstrated navigational ease as well as good question comprehension and response accuracy. CONCLUSIONS: The Cancer Patient Tobacco Use Questionnaire (C-TUQ) can be used as a standardized item set to accelerate the investigation of tobacco use in the cancer setting. Cancer 2016;122:1728-34. © 2016 American Cancer Society.

National Cancer Institute's Small Grants Program for behavioral research in cancer control boosts careers for new investigators and fulfills NIH research priorities.

BACKGROUND: In 1998, the NIH's National Cancer Institute created the Behavioral Research Program (BRP) within the Division of Cancer Control and Population Sciences. A primary goal of the BRP is to stimulate and expand the field of behavioral research in cancer prevention and control. To help achieve this end, BRP created the Small Grants Program. This study examines the effect of the program on the careers of new investigators in cancer prevention and control. METHODS: A mixed-method analysis was conducted on data from a grantee survey and publication and post-award activity records. RESULTS: A majority of grantees (n=197) submitted additional research grant applications, and of these grantees, 37% (n=73) were awarded funding from the NIH and 20% (n=40) received funding at the R01 level. Grantees published research results in journals or presented at professional conferences. Of the 47 grantees who provided their curriculum vitae, 72% (n=34) published or had in press at least one article resulting from their small grant (R03) and 40% (n=19/47) published at least one article as lead author. These articles were cited a total of 134 times in 85 journals. CONCLUSIONS: By supporting investigators' initial behavioral research applications, the Small Grants Program seems to open the door to additional "independent" research opportunities and fulfills the NIH's goals of supporting early career investigators and stimulating promising new areas of cancer research.

Cancer-related health disparities in women.

OBJECTIVES: This article synthesizes information about cancer in 9 populations of minority women: Mexican American, Puerto Rican, Cuban American, African American, Asian American, Native Hawaiian, American Samoan, American Indian, and Alaska Native. METHODS: Cancer registry data, social indicators, government sources, and published articles were searched for information on the background and cancer experience of these 9 racial/ethnic groups. RESULTS: Approximately 35 million women in these racial/ethnic groups live in the United States, and their numbers are increasing rapidly. Since 1992, incidence rates for major cancer sites have slowed or decreased among these groups, but declines in mortality have not occurred or have been smaller than for Whites. Gaps in early detection have narrowed, but minority women still lag behind Whites. Smoking and obesity remain common in these populations. CONCLUSIONS: More culturally appropriate interventions and research are needed, and these efforts must involve the community and raise the quality of health services.