Subject(s)

Antineoplastic Agents/pharmacology , Gene Expression Regulation, Neoplastic , Multiple Myeloma/diagnosis , Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors , Peptides/pharmacology , Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors , bcl-X Protein/antagonists & inhibitors , Aged , Aged, 80 and over , Aniline Compounds/chemical synthesis , Aniline Compounds/pharmacology , Antineoplastic Agents/chemical synthesis , Biological Assay , Bridged Bicyclo Compounds, Heterocyclic/chemical synthesis , Bridged Bicyclo Compounds, Heterocyclic/pharmacology , Cell Line, Tumor , Cytochromes c/metabolism , Female , Humans , Male , Middle Aged , Mitochondria/drug effects , Mitochondria/metabolism , Mitochondria/pathology , Multiple Myeloma/genetics , Multiple Myeloma/metabolism , Multiple Myeloma/pathology , Myeloid Cell Leukemia Sequence 1 Protein/genetics , Myeloid Cell Leukemia Sequence 1 Protein/metabolism , Organ Specificity , Peptides/chemical synthesis , Plasma Cells/drug effects , Plasma Cells/metabolism , Plasma Cells/pathology , Proto-Oncogene Proteins c-bcl-2/genetics , Proto-Oncogene Proteins c-bcl-2/metabolism , Recurrence , Sulfonamides/chemical synthesis , Sulfonamides/pharmacology , bcl-X Protein/genetics , bcl-X Protein/metabolism