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1.
Obes Surg ; 27(3): 630-640, 2017 03.
Article in English | MEDLINE | ID: mdl-27448233

ABSTRACT

BACKGROUND: Laparoscopic adjustable gastric banding (LAGB) remains one of the most performed bariatric procedures worldwide, but a few long-term studies have been reported often with limited data at time of longest follow-up. We review our 18-year LAGB experience with special regard to weight loss failure and long-term complications leading to band removal. METHODS: We performed 897 LAGB procedures from April 1996 to December 2007: 376 using the perigastric dissection and 521 using the pars flaccida dissection. We performed a retrospective analysis of the data of this consecutive series. Failure was defined as band removal with or without conversion to another procedure or excess weight loss (EWL%) <25 %. RESULTS: There were 120 men and 770 women. Mean age was 39.5 years, and mean BMI was 45.6 kg/m2. Mean follow-up was 14.6 years (range 101-228 months) with 90 % follow-up beyond 10 years. Ten (1.1 %) had early complications and 504 (56 %) late complications. Overall, 374 (41.6 %) bands were explanted for complications, weight regain, or intolerance. Mean 15-year EWL% in patients with band in place was 41.73 %. Over time, band failure rate increases from 18.4 % at 2 years to 43 % at 10 years and more than 70 % beyond 15 years. CONCLUSIONS: Despite good initial results, late complications, weight regain, and intolerance lead to band removal in nearly half of the patients over time. However, given that there is no good information on alternative procedures in the long term and considering its reversibility and safety still has a place in the treatment of morbid obesity for informed and motivated patients.


Subject(s)
Gastroplasty , Obesity, Morbid/surgery , Adult , Female , Follow-Up Studies , Gastroplasty/methods , Gastroplasty/rehabilitation , Hospitals, University , Humans , Laparoscopy/methods , Male , Middle Aged , Obesity, Morbid/rehabilitation , Reoperation , Retrospective Studies , Time Factors , Treatment Outcome , Weight Loss
2.
J Visc Surg ; 149(2): e143-52, 2012 Apr.
Article in English | MEDLINE | ID: mdl-22386891

ABSTRACT

BACKGROUND: There are conflicting results concerning the bariatric effectiveness of adjustable gastric banding in super-obese patients with a Body Mass Index (BMI) more or equal to 50 kg/m(2). METHOD: A cohort of 186 patients with a BMI greater or equal to 50 kg/m(2) who underwent adjustable gastric banding (AGB) at the Bichat-Claude-Bernard University Hospital (Paris, France) were prospectively entered into a database. The following data were recorded: BMI, percentage of BMI loss, percentage of excess weight lost (%EWL), complications, and surgical re-interventions. Loss of greater than 50% of excess weight was considered a success (primary endpoint). A %EWL of less than 25% after one year, or the removal of the gastric band was considered a failure. RESULTS: Thirty-five men (18.8%) and 151 women (81.2%), with a mean age of 38.9 years (range: 16-65) underwent AGB between September 1995 and December 2007. The mean BMI was 55.06 kg/m(2) (range: 50-74.4). Mean follow-up was 112.5 months with a minimum of 28 months and a maximum of 172 months. The follow-up rate was maintained at 89% at ten years. The technique of AGB was by "peri-gastric dissection" in the first 115 patients (61.82%) and by "pars flaccida dissection" in 71 patients (38.17%). The gastric band was removed in 87 of 186 patients (46.8%); band ablation was due to a complication of the gastric band in 62 of these cases (33.3%), to failure of weight loss in 23 cases (12.4%), and to patient request in two cases (1%). The major complications requiring re-operation were: chronic dilatation of the proximal gastric pouch (27 patients - 14.5%), acute dilatation (21 patients - 11.3%), intragastric migration of the prosthesis (six patients - 3.2%), reflux esophagitis (six patients - 3.2%), infection of the gastric band (one patient - 0.5%), and Barrett's esophagus (one patient - 0.5%). No statistically significant difference was found between the two operative techniques with regard to the possibility of preserving the gastric band for ten years. For patients who underwent band removal, no further follow-up analysis of patient data after band ablation was performed. The results were best at two years after AGB with a median BMI of 42.72 kg/m(2), a band removal rate of 8.6% (16 of 186 patients), and a failure rate of 16.4% (28 of 170 patients) of those patients who still had their band in place. However, at 10 years, the picture was completely reversed with a band removal rate of 52.2% (47 of 90 patients), a failure rate of 22% (seven of 33 patients) of those who still had their band in place, and a median BMI of 43.43 kg/m(2). CONCLUSION: Laparoscopic gastroplasty using the adjustable gastric band appeared to be a promising intervention for super-obese patients when the results at two years were analyzed - fairly simple to perform, with perioperative morbidity and mortality near zero. However, these results do not persist in the long-term for super-obese patients. At ten years, only 11% of patients (nine of 80) have successful bariatric results (%EWL>50%) and we were forced to remove the gastric band in 52.2% of patients (47 of 90) because of complications, regardless of the initial operative technique used. Given these results, AGB gastroplasty is not a recommended method for super-obese patients and we believe that a BMI greater or equal to 50 kg/m(2) is a contra-indication for this procedure.


Subject(s)
Gastroplasty/methods , Obesity, Morbid/surgery , Adolescent , Adult , Aged , Body Mass Index , Female , Follow-Up Studies , Humans , Kaplan-Meier Estimate , Laparoscopy , Male , Middle Aged , Postoperative Complications/epidemiology , Prospective Studies , Reoperation/statistics & numerical data , Treatment Outcome , Weight Loss , Young Adult
3.
Ann Dermatol Venereol ; 134(1): 65-7, 2007 Jan.
Article in French | MEDLINE | ID: mdl-17384548

ABSTRACT

BACKGROUND: Interferon alpha is approved for the treatment of Kaposi's sarcoma in HIV infected patients. Hemolytic and uremic syndrome (HUS) is a rare side-effect of interferon alpha and has been reported primarily in chronic myelogenous leukemia. CASE REPORT: A 44-year-old HIV-infected woman from Cameroon was admitted for treatment of cutaneous Kaposi's sarcoma. Two days later, she presented severe HUS. Abdominal pains subsequently revealed non-occlusive mesenteric ischemia. The patient rapidly improved after interferon withdrawal. DISCUSSION: To our knowledge this is the first case of HUS induced by interferon alpha given for Kaposi's sarcoma. Further, no cases of acute mesenteric ischemia have been reported with interferon alpha. It is possible that the condition may have been induced or aggravated by HUS or a low infusion rate. Interferon can exert vascular toxicity on both the mesenteric vessels and the renal vessels in a setting of microangiopathy.


Subject(s)
Acquired Immunodeficiency Syndrome/complications , Antineoplastic Agents/adverse effects , Hemolytic-Uremic Syndrome/chemically induced , Interferon-alpha/adverse effects , Ischemia/chemically induced , Mesentery/blood supply , Sarcoma, Kaposi/drug therapy , Sarcoma, Kaposi/etiology , Skin Neoplasms/drug therapy , Skin Neoplasms/etiology , Acute Disease , Adult , Female , Humans , Interferon alpha-2 , Recombinant Proteins
4.
Obes Surg ; 17(11): 1431-4, 2007 Nov.
Article in English | MEDLINE | ID: mdl-18219768

ABSTRACT

BACKGROUND: Vertical banded gastroplasty (VBG) was the restrictive procedure of choice for many years. However, VBG has been associated with a high rate of long-term failure. We reviewed our experience of conversion of failed VBG to Roux-en-Y gastric bypass (RYGBP). METHODS: The data on all patients undergoing conversion of failed VBG to RYGBP were reviewed. Failed VBG was defined as insufficient weight loss (BMI > 35 kg/m2) and/or VBG-related complications. RESULTS: We performed 24 conversions from VBG to RYGBP. Median age was 40 +/- 8 years (range 28 to 61). Preoperative weight was 111 +/- 25 kg (range 85 to 181), and median BMI was 41 +/- 8 kg/m2 (range 30 to 69 kg/m2). Indication for conversion was: VBG failure in 18 patients and VBG complications in 6 patients. A gastrectomy (total or proximal) had to be performed in 5 cases (21%). The conversion was performed by laparoscopy in 13 cases. Postoperative complications occurred in 4 patients (16.7%). There were no leaks, nor mortality. Postoperative BMI was 31 kg/m2 (range 25 to 42) at a median follow-up of 12 months (range 3 to 36 months). The average percentage of excess weight loss was 62% at 1 year. CONCLUSION: VBG has been associated with a significant reoperation rate for failure and/or complications. Conversion to RYGBP is effective in terms of weight loss and treatment of complications after VBG. Gastrectomy and resection of the staple-line could reduce such complications as leaks and mucocele. Although technically challenging, conversion of VBG to RYGBP is feasible, with acceptable morbidity and no mortality. The conversion is feasible laparoscopically.


Subject(s)
Gastric Bypass , Gastroplasty/adverse effects , Obesity, Morbid/surgery , Adult , Body Mass Index , Female , Follow-Up Studies , Humans , Male , Middle Aged , Reoperation , Retrospective Studies , Treatment Failure
5.
Int J Gynecol Cancer ; 15(6): 1203-5, 2005.
Article in English | MEDLINE | ID: mdl-16343214

ABSTRACT

Adenocarcinomas developing in endometriotic lesions have been reported, most commonly in the ovary. The rectovaginal septum is a rare location of this neoplastic transformation. We report a case of primary adenocarcinoma arising from endometriosis of the rectovaginal septum in a 25-year-old woman presenting with lower abdominal pain and dyspareunia. Diagnostic and treatment modalities were discussed. Immunohistochemical studies of different keratin subtypes and CA125 expression of the tumor cells are of interest for the diagnosis. Preoperative radiation therapy promotes clinical symptoms relief, tumor volume reduction, and better radical surgical approach.


Subject(s)
Adenocarcinoma/etiology , Endometriosis/complications , Rectal Neoplasms/etiology , Vaginal Neoplasms/etiology , Adenocarcinoma/therapy , Adult , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Cisplatin/administration & dosage , Colectomy , Female , Gynecologic Surgical Procedures , Humans , Neoadjuvant Therapy , Paclitaxel/administration & dosage , Radiotherapy , Rectal Neoplasms/therapy , Treatment Outcome , Vaginal Neoplasms/therapy
7.
Gynecol Obstet Fertil ; 32(3): 199-209, 2004 Mar.
Article in French | MEDLINE | ID: mdl-15123117

ABSTRACT

OBJECTIVES: To assess the value of MRI and ano-rectal endosonography (ARES) for the diagnosis and surgical prognosis of rectovaginal septum endometriosis and to analyse the surgical management in order to evaluate its functional results and complications. PATIENTS AND METHODS: Retrospective study of 50 consecutive patients operated for a clinical presumption of endometriosis nodule of the recto vaginal septum. Thirty-nine patients had a MRI, 31 an ARES and 28 both exams. All the patients had a complete dissection of the rectovaginal septum and all lesions were excised. RESULTS: For the diagnosis of rectovaginal septum endometriosis nodule, MRI results are: sensitivity 73%, specificity 50%, positive predictive value (PPV) 89%, negative predictive value (NPV) 25%; for uterosacral ligaments involvement: sensitivity 84%, specificity 95%, PPV 94%, NPV 86% and for rectal wall infiltration: sensitivity 53%, specificity 82%, PPV 69%, NPV 69%. The ARES results for diagnosis of rectovaginal septum endometriosis nodule are: sensitivity 93%, specificity 100%, PPV 100%, NPV 50% and for rectal wall infiltration: sensitivity 100%, specificity 71%, PPV 81%, NPV 100%. ARES appeared more sensitive than MRI for the detection of rectal wall infiltration (P = 0.002) and for rectovaginal septum endometriosis nodule diagnosis (P = 0.03). Eighty-nine percent of the patients had a coelioscopy in first intention and 15 laparoconversions were performed, 11 in order to perform a digestive resection: 45 nodules were found. In 43cases the nodule was excised, associated to 19 digestive resections, 30 colpectomys, and 22 uterosacral ligaments resections. Three patients required an additional surgical treatment by Hartman's procedure with Mickulicz's drainage for peritonitis. Forty-one nodules were endometriosis nodules: the two other cases were fibrosis nodules. Thirty-three patients were interviewed about the evolution of their pains over a mean history of 20 months: 90% of the patients were satisfied with the management results. DISCUSSION AND CONCLUSIONS: Our data support the efficiency of MRI for rectovaginal septum endometriosis nodule and uterosacral ligaments involvement diagnosis; accord ARES to rectovaginal septum endometriosis nodule diagnosis and its reliability in establishing a diagnosis of rectal wall involvement. The surgical cure of rectovaginal septum nodules without digestive infiltration is performed by coelioscopic or coelio-vaginal procedure, but in case of associated digestive affliction, laparotomy is actually the standard procedure in order to achieve a complete cure of the lesions. Complications, in particular peritonitis, are not frequent. Our data support the efficiency of radical surgical treatment for the improvement of pain symptoms. Results on fertility seem to be satisfactory, but complication risks suggest being careful in this indication. Clinical examination during a catamenial period is essential in order to evoke the diagnosis. MRI yields a complete map of the sub-peritoneal and peritoneal lesions and ARES allows for the diagnosis of an infiltration of the rectal wall. Pre-operative association of those two exams is actually indispensable for the surgical management of those patients, which consists of complete excision of endometriosical lesions and is efficient at treating pain symptoms and fertility. Complications are rare but severe, therefore, justifying a cure in specialised centres.


Subject(s)
Endometriosis/surgery , Rectal Diseases/surgery , Vaginal Diseases/surgery , Adult , Endometriosis/diagnosis , Endometriosis/diagnostic imaging , Endosonography/methods , Female , Humans , Magnetic Resonance Imaging/methods , Middle Aged , Predictive Value of Tests , Rectal Diseases/diagnosis , Rectal Diseases/diagnostic imaging , Retrospective Studies , Risk Factors , Sensitivity and Specificity , Treatment Outcome , Vaginal Diseases/diagnosis , Vaginal Diseases/diagnostic imaging
8.
Ann Chir ; 128(3): 150-8, 2003 Apr.
Article in French | MEDLINE | ID: mdl-12821080

ABSTRACT

AIM OF THE STUDY: Damage control laparotomy is a new approach to the more severe abdominal traumas. It stems from a better understanding of the physiopathology of the haemorragic shock. PATIENTS AND METHODS: A national retrospective study from 27 centers about 109 trauma patients who underwent a damage control procedure between January 1990 and December 2001, is analysed. Surgical procedures included 97 hepatic packing, 10 abdominal packing, 4 exclusive skin closure, 1 open laparotomy technique and 3 digestive stapplings. RESULTS: The mortality rate is 42%. Eleven abdominal compartment syndromes have occurred with 7 decompressive laparomy (4 deaths). CONCLUSION: This study is based on the largest series of damage control laparotomy published in France. Results in terms of mortality and morbidity are similar to those of published studies from the USA.


Subject(s)
Abdominal Injuries/surgery , Hemorrhage/surgery , Laparotomy/methods , Multiple Trauma/surgery , Resuscitation/methods , Traumatology/methods , Abdominal Injuries/complications , Abdominal Injuries/diagnosis , Abdominal Injuries/mortality , Adolescent , Adult , Age Distribution , Aged , Belgium/epidemiology , Child , Decompression, Surgical/methods , Female , France/epidemiology , Hemorrhage/etiology , Hemorrhage/mortality , Humans , Injury Severity Score , Male , Middle Aged , Multiple Trauma/complications , Multiple Trauma/diagnosis , Multiple Trauma/mortality , Patient Selection , Retrospective Studies , Risk Factors , Surgical Stapling/methods , Survival Analysis , Suture Techniques , Time Factors , Treatment Outcome , Tunisia/epidemiology
9.
Intensive Care Med ; 28(5): 594-8, 2002 May.
Article in English | MEDLINE | ID: mdl-12029408

ABSTRACT

OBJECTIVE: To evaluate the time-course of two organ failure scores (SOFA and Goris) after surgery for postoperative peritonitis in critically ill patients according to the persistence/nonpersistence of intraabdominal sepsis (IAS). DESIGN: Retrospective study. PATIENTS: Sixty-two consecutive patients (SAPSII = 38+/-14) admitted in the surgical ICU. METHODS: Patients were classified according to the persistence of IAS (IAS+, n=36) confirmed by a second laparotomy or the lack of IAS (IAS-, n=26) assessed by a favorable 30-day evolution without reintervention. Scores were calculated daily from day 0 preoperatively to postoperative day 5. RESULTS: In both groups, SOFA scores were higher on day 1 when compared to day 0 (8.3+/-3.1 vs 6.1+/-3.7 in the IAS+ group and 5.2+/-3.4 vs 2.7+/-2.7 in the IAS- group). In the IAS- patients, the SOFA score displayed a decrease starting on day 2 when compared to day 1 (4.4+/-3.6 vs 5.2+/-3.4, P=0.03). In contrast, in the IAS+ patients, the SOFA score remained unchanged until day 5. The time course of the Goris score was strictly similar to the SOFA scores. CONCLUSION: In critically ill patients with postoperative peritonitis, the postoperative time course of the SOFA and the Goris organ failure scores was different between patients with or without intra-abdominal persistent sepsis. The lack of improvement of one of these scores on postoperative day 2 may suggest persistent intraabdominal sepsis and supports the need for a new surgical exploration.


Subject(s)
Multiple Organ Failure/diagnosis , Peritonitis/complications , Sepsis/diagnosis , Analysis of Variance , Chi-Square Distribution , Critical Illness , Female , Humans , Male , Middle Aged , Peritonitis/etiology , Peritonitis/surgery , Postoperative Complications , Predictive Value of Tests , Retrospective Studies , Sepsis/etiology , Sepsis/surgery , Severity of Illness Index , Statistics, Nonparametric , Time Factors
10.
Ann Chir ; 125(1): 62-5, 2000 Jan.
Article in French | MEDLINE | ID: mdl-10921187

ABSTRACT

Abbreviated laparotomy and planned reoperation(s) is a new concept in severely injured patients with multivisceral failure by hemorrhagic shock, coagulopathy and hypothermia. The aim of an abbreviated laparotomy is to control hemorrhage, prevent digestive contamination and close the abdominal wall without tension. After a delay for reanimation during 24 to 96 hours, discovery of unknown lesions and anatomic reconstruction will be possible through planned reoperation in better conditions. Emergency reoperation for hemorrhage and abdominal hyperpression severely worsens prognosis.


Subject(s)
Abdominal Injuries/surgery , Gastrointestinal Hemorrhage/surgery , Laparotomy/methods , Abdominal Injuries/pathology , Female , Gastrointestinal Hemorrhage/etiology , Humans , Hypothermia , Lower Body Negative Pressure , Middle Aged , Multiple Organ Failure , Prognosis , Reoperation , Shock, Hemorrhagic , Time Factors
11.
J Laparoendosc Adv Surg Tech A ; 10(3): 155-9, 2000 Jun.
Article in English | MEDLINE | ID: mdl-10883993

ABSTRACT

BACKGROUND AND PURPOSE: Postoperative adhesions are the leading cause of small-bowel obstruction in developed countries. Several arguments suggest that laparoscopy may lead to fewer adhesions than does laparotomy. We report here the short-term results of laparoscopy in patients admitted on an emergency basis for acute small-bowel obstruction secondary to adhesions. PATIENTS AND METHODS: This prospective trial included 134 consecutive patients: 39 underwent emergency surgery, and 95 had laparoscopic adhesiolysis shortly after resolution of the obstruction with nasogastric suction. Of the previous operations for which the dates were known, 16% had taken place within 1 year of the obstruction and 33.5% within 5 years. In all, 27% of the patients had open laparoscopy, and 16% had conversions: 7% after elective laparoscopy and 36% after emergency laparoscopy. RESULTS: There were no operative deaths. One patient underwent a reoperation the following day for fistula after incomplete adhesiolysis attributable to multiple adhesions found during elective laparoscopy. If laparoscopy is considered to have failed when adhesiolysis was incomplete or conversion or reoperation was necessary, our success rate was 80% after elective laparoscopy and 59% after emergency laparoscopy. CONCLUSION: Emergency situations in acute small-bowel obstruction combine several circumstances unfavorable for laparoscopy: a limited work area and a distended and fragile small bowel. Laparoscopic adhesiolysis after the crisis has passed may produce better results, but only long-term follow-up can confirm the role of elective laparoscopy for this indication.


Subject(s)
Intestinal Obstruction/surgery , Laparoscopy , Acute Disease , Adolescent , Adult , Aged , Aged, 80 and over , Emergencies , Female , Humans , Intestinal Obstruction/etiology , Intestine, Small , Male , Middle Aged , Postoperative Complications/surgery , Prospective Studies , Tissue Adhesions/complications , Treatment Outcome
12.
J Nucl Med ; 40(10): 1602-8, 1999 Oct.
Article in English | MEDLINE | ID: mdl-10520698

ABSTRACT

UNLABELLED: Scintigraphy with somatostatin analogs is a sensitive method for the staging and therapeutic management of patients with endocrine gastroenteropancreatic (GEP) tumors. The aim of this study was to compare prospectively somatostatin receptor scintigraphy (SRS) using 111n-pentetreotide with bone scintigraphy using 99mTc-hydroxymethylene diphosphonate for the detection of bone metastases. METHODS: One-hundred-forty-five patients with proven endocrine GEP tumors were investigated. Patients were classified according to the presence of bone metastases as indicated by CT, MRI or histologic data. Group I included 19 patients with confirmed bone metastases, and group II included 126 patients without bone metastases. RESULTS: In group I, SRS was positive in all 19 patients with bone metastases, and bone scintigraphy was positive in 17 patients. Bone metastases were found to occur predominantly in patients with liver metastases. In group 11, 5 patients had recent bone surgery for fracture or arthritis. SRS showed bone uptake in 4 of these patients, and bone scanning showed abnormal uptake in 5. In 7 of the remaining 121 group II patients, SRS was negative and bone scanning showed abnormal bone uptake suggesting bone metastases. The detection of bone metastases was of major prognostic value, because 42% of group 1 patients died during a 2-y follow-up. CONCLUSION: In patients with GEP tumors, the accuracy of SRS appears to be similar to that of bone scintigraphy for the detection of bone metastases.


Subject(s)
Bone Neoplasms/secondary , Digestive System Neoplasms/diagnostic imaging , Pentetic Acid/analogs & derivatives , Receptors, Somatostatin/metabolism , Adult , Aged , Aged, 80 and over , Bone Neoplasms/diagnostic imaging , Carcinoid Tumor/diagnostic imaging , Digestive System Neoplasms/metabolism , Female , Humans , Indium Radioisotopes , Male , Middle Aged , Octreotide/analogs & derivatives , Prospective Studies , Radionuclide Imaging , Radiopharmaceuticals , Somatostatin/analogs & derivatives , Technetium Tc 99m Medronate/analogs & derivatives , Zollinger-Ellison Syndrome/diagnostic imaging
13.
Ann Chir ; 53(1): 29-31; discussion 32, 1999.
Article in French | MEDLINE | ID: mdl-10083666

ABSTRACT

The recurrences of inguinal hernia after onlay mesh may cause technical difficulties for a new repair. The aim of our study was to assess intraoperative findings, feasibility and results of laparoscopic transpreperitoneal mesh onlay in this indication. Twenty-one repairs were performed. In all cases, direct, internal, inguinal recurrences were observed, associated in two cases with an external or femoral recurrence. In 16 cases, there were no adhesions in the peritoneal cavity. The were no conversions and peritonealisation was always completed. The mean length of hospitalization was 2.7 days. Our study suggests that technical errors during the first procedure, insufficient mesh or wrongly positioned are responsible for recurrence and allow reinsertion of a mesh laparoscopy via transpreperitoneal in this indication.


Subject(s)
Hernia, Inguinal/surgery , Laparoscopy/methods , Surgical Mesh , Adult , Aged , Female , Hernia, Inguinal/etiology , Humans , Male , Middle Aged , Peritoneal Cavity/surgery , Recurrence , Reoperation , Treatment Outcome
14.
Gastroenterol Clin Biol ; 21(10): 754-9, 1997.
Article in French | MEDLINE | ID: mdl-9587516

ABSTRACT

BACKGROUND AND AIMS: Mutations of TP53, a tumor suppressor gene, are found in 60% to 70% of colorectal cancers. These mutations usually induce an overexpression caused by modification of the p53 protein conformation. The aim of this study was to investigate whether stool specimens of patients with colorectal cancer contain increased amounts of p53 protein. METHODS: p53 protein was measured using a sandwich enzyme immunoassay in the stool specimens of 52 patients: 25 with colorectal cancer, 4 with colorectal adenomas and 23 apparently free of gastrointestinal disease. Results were expressed as pg/mg of total protein. The presence of fecal occult-blood was searched using Hemoccult II and Hemolex (an immunochemical assay for human hemoglobin). RESULTS: Median concentrations of stool p53 protein were 16.6 pg/mg (range: 0-591 pg/mg) in patients with colorectal cancers, 39.1 pg/mg (range: 5-72 pg/mg) in patients with adenomas and 5.9 pg/mg (range: 0-65 pg/mg) in control subjects. Resection of colorectal cancers caused a marked decrease of stool p53 protein concentrations. When the cut-off value for stool p53 protein was set at 60 pg/mg of fecal protein (concentrations over the 95th percentile), the positivity of the assay was independent of tumor size and Astler-Coller stage, but weakly associated with rectal location of cancer. The sensitivity of stool p53 protein for colorectal cancer was 44%, and the specificity was 96%. In contrast, the sensitivity of Hemoccult II and Hemolex tests was 48% and 44%, whereas their specificity was 91% and 96%, respectively. CONCLUSION: The detection of p53 protein is achievable in stool, but this assay is not more efficient than fecal occult blood tests for detection of colorectal cancer.


Subject(s)
Adenocarcinoma/chemistry , Colorectal Neoplasms/chemistry , Feces/chemistry , Tumor Suppressor Protein p53/analysis , Adenocarcinoma/diagnosis , Adenocarcinoma/surgery , Aged , Aged, 80 and over , Colorectal Neoplasms/diagnosis , Colorectal Neoplasms/surgery , Enzyme-Linked Immunosorbent Assay , Feasibility Studies , Female , Humans , Male , Middle Aged , Occult Blood , Postoperative Period , Sensitivity and Specificity
15.
J Chir (Paris) ; 134(4): 185-8, 1997 Sep.
Article in French | MEDLINE | ID: mdl-9499948

ABSTRACT

Bleeding after needle liver biopsy (NLB) is well known but surgical hemostasis in these circumstances is rarely assessed. We report 7 cases of laparotomy for hemostasis after NLB. The 7 NLB were done for 6 diffuse hepatopathies and one focal lesion. Three patients had hemostasis disorders at the time of the biopsy. None had cirrhosis. Five patients were operated few hours after the biopsy. Direct hemostasis was performed in 6 cases and in hepatectomy in one. Two patients were reoperated for three repeated hemostasis. Two died. The occurrence of hemoperitoneum after NLB is very rare but serious, occasionally occurring a few days after the biopsy. The respect of contre-indications and technical precautions are the best prevention of this kind of accident.


Subject(s)
Hemorrhage/etiology , Hemostasis, Surgical/methods , Liver Diseases/pathology , Liver/pathology , Adolescent , Adult , Aged , Biopsy/adverse effects , Female , Follow-Up Studies , Hepatectomy , Humans , Liver Diseases/complications , Male , Middle Aged
16.
Ann Chir ; 50(4): 352-5, 1996.
Article in French | MEDLINE | ID: mdl-8758527

ABSTRACT

Surgical gloves constitute part of the most exposed barrier material, as one half of accidental exposures to blood in the exposures to blood in the operating room involve the hands. Approximately 15% of gloves tested at the end of the operation were found to be perforated. Double gloving lowers this rate to 5% with apparently acceptable tolerance for surgeons. Although surgical glove are initially impermeable to various viruses, the porosity increases with the duration of use. This porosity is related to hydratation and deformation of latex fibres. The maintenance of a good barrier function of surgical gloves requires regular changing, at least hourly, in the current state of knowledge.


Subject(s)
Acquired Immunodeficiency Syndrome/transmission , Gloves, Surgical , Infectious Disease Transmission, Patient-to-Professional , Surgical Procedures, Operative , Humans , Risk Factors
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