ABSTRACT
Aim: To study the effectiveness of anterior and middle superior alveolar nerve block (AMSA) for anesthesia of unilateral maxillary teeth, i.e., from central incisor to second premolar of the same side by using conventional syringe and needle. Material and Method: Two hundred patients who needed extraction of any tooth/teeth in the region of central incisor to second premolar of the same side were randomly chosen for the study. Result: Successful anesthesia was found in 71.5% of cases. However, the highest success rate was seen with first premolar (82.2%) and minimum with lateral incisor (67.5%), and induction time ranged from 6 to 12 min and duration for 30-45 min. Conclusion: Using conventional syringe and needle, AMSA can be administered to achieve adequate soft tissue anesthesia of maxillary central incisors, canine and premolars of that side and pulpal anesthesia to a good extent (more so with first premolar), without affecting the muscles of facial expressions and lip numbness, reducing the requirement of multiple injections for the same.
ABSTRACT
PURPOSE: To evaluate the safety and efficacy of autologous adult live cultured buccal epithelial cells (AALBEC) in treatment and management of bulbar urethral stricture in men. METHODS: This was a prospective, multi-center, open-label, single-arm phase 2b study. A total of 18 male patients with bulbar urethral stricture of at least 1 - 4 cm in length were enrolled in the study. All 16 patients had AALBEC implanted and were included in the safety set. Change in total American Urology Association (AUA) symptom score, urinary flow rates assessed by uroflowmetry and a requirement for surgery after 24 weeks from baseline were determined in patients. Data of treatment efficacy were analyzed. RESULTS: The AUA score at baseline was 21 (3.9) that showed a statistically significant reduction starting from week 2 [8 (4.4), p = 0.0001] which sustained until week 24 [2 (1.2), p = 0.0005]. Overall mean total AUA symptom score was reduced by 90.5% after the treatment. Significant reductions from baseline at week-24 were also observed in voiding time (92.5 (47.3) vs. 51.9 (17.4) s, p = 0.0046) and flow time [86.9 (48.2) vs. 47.9 (19.6) s, p = 0.0052]. All patients showed absence of any significant adverse events. CONCLUSION: Significant improvement was seen in the AUA symptom score and uroflowmetry parameters and no patients required surgery during 24 weeks post-treatment. It can be concluded that AALBEC is a safe and effective treatment for bulbar urethral stricture of 1 - 4 cm length to improve the quality of life and the physiological function of urethra.
