Subject(s)
Carcinoma, Squamous Cell/etiology , Carcinoma, Squamous Cell/pathology , Cell Transformation, Neoplastic/pathology , Extracellular Matrix/pathology , Mouth Neoplasms/etiology , Mouth Neoplasms/pathology , Oral Submucous Fibrosis/pathology , Biomechanical Phenomena , Epithelial-Mesenchymal Transition , Extracellular Matrix/metabolism , Fibrosis , Humans , Matrix Metalloproteinases/metabolism , Mechanotransduction, Cellular , Oral Submucous Fibrosis/complications , Oral Submucous Fibrosis/metabolism , Signal Transduction , Transforming Growth Factor beta/metabolismABSTRACT
Oral submucous fibrosis (OSF) is characterized by excessive fibrosis of submucosa. The degree of vascularity in OSF has always been a matter of debate. Angiogenesis is the key mechanism involved in regeneration and repair. It also plays an important role in various pathologic conditions. Angiogenesis may contribute to the progression of fibrosis in fibrotic disorders. Inhibition of pathological angiogenesis is considered to be a new strategy for the treatment of various fibrotic disorders. In OSF, angiogenesis can be related to progression fibrosis. This article briefly describes the role of angiogenesis in pathogenesis of fibrosis in OSF and the importance of inhibition of pathologic angiogenesis in its prevention and treatment. CLINICAL SIGNIFICANCE: Understanding the association between angiogenesis and fibrogenesis can help in developing new therapeutic strategies for treatment of OSF.
Subject(s)
Neovascularization, Pathologic , Oral Submucous Fibrosis/pathology , Disease Progression , HumansABSTRACT
BACKGROUND: Argyrophilic nucleolar organizer regions (AgNORs) is demonstrated to be useful in diagnostic pathology, mainly to distinguish benign lesions from their malignant counterparts. We aimed to correlate AgNORs pleomorphism with the severity of lesion in oral submucous fibrosis (OSMF) and oral squamous cell carcinoma (OSCC) using a retrospective study on 45 archival tissues. MATERIALS AND METHODS: Silver nitrate staining was performed on archival tissues consisting of 20 OSMF and 20 OSCC. Five biopsies from normal oral mucosa acted as a control. One hundred cells per slide were observed for AgNORs dots, which were classified as typical (spherical) and atypical (large, kidney-shaped and clustered). RESULTS: A positive and significant correlation was found between increased atypical shapes and increasing grades of OSMF and OSCC. CONCLUSIONS: AgNORs pleomorphism can be a reliable criterion to assess disease severity and progression in OSMF and OSCC.
