Clinicopathological characteristics of desmoplastic ameloblastoma: A systematic review.

The aim of the present review was to systematically present the clinicopathological data of desmoplastic ameloblastoma (DA) from articles published in the literature. A comprehensive search of the databases (PubMed, Medline, SCOPUS, Web of Science, and Google Scholar) for published articles on DA was conducted. A total of 238 cases were identified and analyzed from 76 published papers. DA showed a slight male predilection (male: female=1.07:1) with a predominance in the fourth and fifth decades of life. Mandibular involvement (52.55%) was most commonly seen with a marked tendency for the anterior region (mandible: 40.9%, maxilla: 48.07%). The size of the lesion ranged from .5 cm to 20.4 cm, with the majority of cases measuring more than 3 cm in size (53.84%). Radiologically, most of the lesions presented mixed radiolucency and radiopacity (62%), and root resorption was observed in only seven cases. The majority of the lesions showed ill-defined margins upon radiographic examination (65.78%). Most of the cases were treated with resection (78.57%), and five of the 10 recurrent cases were treated by enucleation/curettage. DA is characterized by the unique presentation of clinicopathological parameters. It is not possible to comment on its aggressive/recurrent nature and best treatment modality due to inadequate follow-up data.

Dental records of forensic odontological importance: Maintenance pattern among dental practitioners of Pune city.

CONTEXT: Forensic odontology plays a pivotal role in the identification of victims in mass disasters with the help of "Preserved dental records" available with the general dental practitioners (GDPs). However, the status of such dental records of forensic importance has not been studied extensively. AIM: To study the current status of awareness and practice of dental record maintenance by GDPs of Pune. MATERIALS AND METHODS: A cross-sectional study was conducted among 100 randomly selected GDPs from Pune. Data was collected in a personalized manner by means of a questionnaire. RESULTS: Six percent of GDPs do not maintain any records of the patient, 11% of them do not record about developmental dental anomalies, and 22% GDPs do not retain radiographs. Sixty-seven percent GDPs mention about the use of abbreviations while recording history. Only 17% of GDPs record denture marking and 11% take conformity certificate for the denture. Thirty percent GDPs do not mention the serial number of an implant whereas 17% of them do not mention about the prescribed medication. Five percent GDPs handover original dental record to the patient and 91% said that they discard casts and models immediately after treatment. CONCLUSION: There was inadequate knowledge and lack of practice regarding proper record maintenance among GDPs.

FAK is overexpressed in keratocystic odontogenic tumor: a preliminary study.

BACKGROUND: Focal adhesion kinase (FAK) is an important mediator of cell adhesion, growth proliferation, survival, angiogenesis, and migration. FAK is overexpressed in many locally invasive and malignant lesions including oral cancer. Looking at the tumorigenic nature of keratocystic odontogenic tumor (KCOT), which involves local invasion, proliferation, and recurrence, we hypothesized strong expression of FAK in the epithelial lining of KCOT. MATERIALS AND METHODS: 34 KCOTs, 11 orthokeratinized odontogenic cysts (OOCs), 25 radicular cysts (RCs), 17 dentigerous cysts (DCs), and 25 dental follicles (DFs) were retrieved from archives and subjected to the immunohistochemical analysis using FAK antibody. RESULTS: In KCOT, strong expression was observed in 22 (62.8%) cases followed by weak and negative expression in 9 (25.71%) and 4 (11.4%) cases, respectively. Negative expression was seen in 7 (63.63%) cases of OOC, while 4 (36.36%) showed weak expression. In case of RC, 20 (80%) cases displayed negative expression and 4 (16%) and 1 (4%) cases showed weak and strong expressions, respectively. In case of DC, negative expression was seen in 14 (82.35%) cases and weak expression in 3 (17.64%) cases. DF was characterized by negative [21 (84%)] and weak expression [4 (16%)]. Nuclear expression of FAK was seen only in KCOT (11 cases). There was statistically significant higher FAK expression in KCOT as compared to OOC, RC, DC, and DF (P < 0.00001). CONCLUSION: FAK molecule could be an important player in tumorigenesis of KCOT and thus is a potential target for future drug development.