ABSTRACT
Silica treated mice when challenged with Plasmodium berghei showed increase in duration of prepatent(PP) and survival period (SP) and median survival day(MSD) as compared with controls. Daily parasite density curve during the course of infection was similar to control. Response to the parasite challenge, however, was dependent on the dose of silica. No increase in SP at 0.7 mg and in PP at 35 mg (cumulative doses) dose was observed. A dose upto 5 mg per mouse before challenge resulted in protection of the animal. No mortality was recorded in mice which received silica alone (35 mg; 5 mg/day x 7 days). Death due to lethal P.berghei infection could be delayed or prevented by altering/reducing the functional activities of macrophages during the course of infection.
Subject(s)
Immunity/physiology , Malaria/immunology , Plasmodium berghei , Silicon Dioxide/analysis , Animals , Biological Assay , Malaria/metabolism , Male , MiceABSTRACT
Studies on adult densities, vector incrimination and breeding habitats of An. culicifacies and An. stephensi were carried out during June 1984 to May 1986 in three different ecological areas of urban Delhi. Both An. culicifacies and An. stephensi prevailed throughout the year in peri-urban areas with higher densities during the post-monsoon months. In south and northwest areas, low densities of these vector species were recorded. An. culicifacies was found naturally infected with sporozoites in peri-urban and south areas, whereas An. stephensi showed gland infection in south areas only. Out of 827 blood smears collected, 302 were positive for malaria parasites. Of the positives, P. vivax formed 48.3% and P. falciparum 51.7%. Peri-urban areas showed a higher number of malaria cases than south and northwest areas.
Subject(s)
Anopheles/parasitology , Insect Vectors/parasitology , Malaria, Falciparum/transmission , Malaria, Vivax/transmission , Plasmodium/isolation & purification , Animals , Anopheles/physiology , Humans , India/epidemiology , Insect Vectors/physiology , Malaria, Falciparum/epidemiology , Malaria, Vivax/epidemiology , Plasmodium falciparum/growth & development , Plasmodium falciparum/isolation & purification , Plasmodium vivax/growth & development , Plasmodium vivax/isolation & purification , Population Density , Salivary Glands/parasitology , SeasonsSubject(s)
Malaria/epidemiology , Adult , Child , Child, Preschool , Female , Humans , India/epidemiology , MaleABSTRACT
WHO micro in vitro tests for chloroquine resistance in P. falciparum were carried out during November, 1987 in Madras city, Tamil Nadu and in Kundam PHC of Jabalpur district, Madhya Pradesh. Out of 6 samples tested from Madras city, 5 showed resistance to chloroquine. Likewise, out of 14 samples tested in Jabalpur, 12 (85.7%) showed resistance to chloroquine. All the 20 samples showed normal susceptibility to mefloquine.
