Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Neurosci Lett ; 340(3): 201-4, 2003 Apr 17.
Article in English | MEDLINE | ID: mdl-12672541

ABSTRACT

Recent reports of human immunodeficiency virus-1 (HIV-1) infection of astrocytes suggest a role for astrocytes in HIV encephalitis. In this study, we infected a human astrocytoma cell line with a pathogenic simian HIV (SHIV(50OLNV)) and examined growth patterns and immunomodulatory genes. Approximately 1% of uninfected cells in culture expressed glial fibrillary acid protein (GFAP) whereas 40% of the cells expressed GFAP at 7 days post-inoculation along altered growth patterns. Using targeted cytokine cDNA arrays, we found that SHIV(50OLNV) infection resulted in the up-regulation of several genes including metalloproteinase bone morphogenic protein 1 and chemokines monocyte chemoattractant protein 1 and stromal cell derived factor 1alpha. These data suggest that astrocytic activation, altered morphology and up-regulation of immunomodulatory genes in response to SHIV infection may participate in initiation of inflammation and trafficking of infected monocytes/macrophages into the central nervous system, potentiating the development of HIV encephalitis.


Subject(s)
Astrocytoma/metabolism , Astrocytoma/virology , HIV-1/physiology , Simian Immunodeficiency Virus/physiology , Up-Regulation/physiology , Animals , Astrocytoma/genetics , Gene Expression Regulation, Viral/physiology , Glial Fibrillary Acidic Protein/biosynthesis , Glial Fibrillary Acidic Protein/genetics , HIV-1/genetics , Humans , Simian Immunodeficiency Virus/genetics , Up-Regulation/genetics
SELECTION OF CITATIONS
SEARCH DETAIL
...