1.
Pulm Circ
; 3(1): 217-25, 2013 Jan.
Article
in English
| MEDLINE
| ID: mdl-23662200
ABSTRACT
In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consider alternative clinical trial designs in pulmonary hypertension and here discusses their merits, limitations and challenges to implementation of novel approaches.