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3.
Hong Kong Med J ; 24(1): 25-31, 2018 02.
Article in English | MEDLINE | ID: mdl-29326400

ABSTRACT

INTRODUCTION: Angiosarcoma is a rare aggressive sarcoma that occurs mostly in the skin of the head and neck in the elderly population. The optimal management is dubious and most studies are from Caucasian populations. We aimed to examine the treatment and outcome of this disease in Chinese patients. METHODS: Data of patients with histopathologically verified cutaneous angiosarcoma of the head and neck during December 1997 to September 2016 were retrieved from our hospital cancer registry. The demographic data, clinicopathological information, modality of treatment, and outcomes were reviewed. RESULTS: During the study period, 17 Chinese patients were treated. Their median age was 81 years. The tumours were present in the scalp only (n=11), face only (n=4), or both scalp and face (n=2). Only two patients had distant metastases. The modalities of treatment were surgery (n=6), surgery and adjuvant radiotherapy (n=1), palliative radiotherapy (n=5), or palliative chemotherapy (n=3). The remaining two patients refused any treatment initially. Of the seven patients treated surgically, there were four local and two regional recurrences. The median time to relapse was 7.5 months. Overall, 16 patients had died; causes of death were disease-related in 12 whereas four other patients died of inter-current illnesses. One patient was still living with the disease. The median overall survival was 11.1 months and the longest overall survival was 42 months. CONCLUSION: The outcome of angiosarcoma in our series is poor. A high index of suspicion is mandatory for prompt diagnosis. Adjuvant radiotherapy is recommended following surgery. The benefit and role of systemic treatment in various combinations with surgery or radiotherapy require further study.


Subject(s)
Face/pathology , Facial Neoplasms/therapy , Hemangiosarcoma/therapy , Scalp/pathology , Skin Neoplasms/therapy , Aged , Aged, 80 and over , Cancer Care Facilities , Cause of Death , Combined Modality Therapy , Facial Neoplasms/mortality , Female , Hemangiosarcoma/mortality , Hong Kong , Humans , Male , Neoplasm Invasiveness/pathology , Neoplasm Recurrence, Local/pathology , Neoplasm Staging , Radiotherapy, Adjuvant , Retrospective Studies , Skin Neoplasms/mortality
6.
Int J Surg Case Rep ; 39: 185-187, 2017.
Article in English | MEDLINE | ID: mdl-28846952

ABSTRACT

INTRODUCTION: Incisional hernia is not an uncommon complication after abdominal operation, and laparoscopic ventral hernia repair with mesh is commonly performed nowadays. It is thought to have less complication compare to the traditional open repair, yet late complication is still observed occasionally and can be disastrous. CASE REPORT: We hereby report a case of abdominal wall necrotizing fasciitis 21 months after laparoscopic incisional hernia repair in lower midline with dual mesh, due to mesh migration and erosion into urinary bladder, resulting in fistulation between bladder and abdominal wall. Repeated debridement and removal of mesh was required for sepsis control and the patient required intensive care support due to multi-organ failure. Subsequent repair of urinary bladder and abdominoplasty was performed after condition stabilized. CONCLUSION: This case was the first reported incident with bladder erosion by dual mesh causing vesico-cutaneous fistula complicated with necrotizing fasciitis. Although dual mesh theoretically reduces the risk of mesh erosion, mesh erosion to viscera can still happen and cause severe complication. Its risk should be balanced and discussed with patient with full consent.

7.
J Laryngol Otol ; 129(8): 788-94, 2015 Aug.
Article in English | MEDLINE | ID: mdl-26072937

ABSTRACT

BACKGROUND: The role of routine intra-operative parathyroid hormone monitoring for sporadic primary hyperparathyroidism is contentious. Satisfactory results can be achieved in high-volume centres. The results of low-volume hospitals are rarely studied. METHODS: A retrospective, non-comparative study was conducted. From November 2002 to October 2012, 105 patients with clinically sporadic primary hyperparathyroidism underwent focused parathyroidectomy without intra-operative parathyroid hormone monitoring. Single adenoma was localised on pre-operative ultrasonography or sestamibi scan. The cure rate, surgical complication rate and pathology findings were evaluated. RESULTS: Most of the operations (63.8 per cent) were performed under local anaesthesia. All but two patients (98.1 per cent) were cured after surgery. There was only one case of double adenomas. No recurrent hyperparathyroidism was observed after a mean follow up of 56.9 months. Surgical complications comprised two cases (1.9 per cent) of transient vocal fold palsy and one case (1.0 per cent) of permanent vocal fold palsy. Seven patients (6.7 per cent) suffered temporary hypocalcaemia. CONCLUSION: Satisfactory results of focused parathyroidectomy without routine intra-operative parathyroid hormone monitoring for appropriately selected primary hyperparathyroidism cases can be attained in a low-volume hospital.


Subject(s)
Adenoma/blood , Adenoma/surgery , Hospitals, Low-Volume , Hyperparathyroidism, Primary/blood , Hyperparathyroidism, Primary/surgery , Monitoring, Intraoperative , Parathyroid Hormone/blood , Parathyroid Neoplasms/blood , Parathyroid Neoplasms/surgery , Parathyroidectomy/methods , Adult , Aged , Anesthesia, General , Anesthesia, Local , Female , Follow-Up Studies , Hong Kong , Humans , Hypocalcemia/blood , Male , Middle Aged , Postoperative Complications/blood , Retrospective Studies
8.
Hong Kong Med J ; 20(2): 156-7, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24714170

ABSTRACT

Goitres usually enlarge and descend caudad into the substernal space and are not palpable. We report on a patient whose goitre spread downward but anterior to the sternum. The thyroid mass was subsequently removed and was proven to be a papillary thyroid carcinoma. The mechanism by which a presternal goitre develops is probably due to invasion and erosion of the strap muscles and the cervical linea alba. The clinical implication of this presentation is complete extirpation of the presternal goitre with a cuff of the strap muscles.


Subject(s)
Carcinoma, Papillary/pathology , Sternum/pathology , Thyroid Neoplasms/pathology , Carcinoma, Papillary/surgery , Fasciotomy , Humans , Male , Middle Aged , Neck Muscles/surgery , Neoplasm Invasiveness , Thyroid Neoplasms/surgery , Thyroidectomy
9.
Hong Kong Med J ; 19(4): 349-51, 2013 Aug.
Article in English | MEDLINE | ID: mdl-23918511

ABSTRACT

Pyriform sinus fistula is important despite its rarity, as it can induce a recurrent neck abscess. Most of the reported cases occur in children and the majority affect only the left side. We report a patient with a pyriform sinus fistula of the right neck in an adult, which was successfully treated by surgery. The aetiology of this entity is also discussed herein.


Subject(s)
Abscess/pathology , Pyriform Sinus/pathology , Respiratory Tract Fistula/pathology , Abscess/etiology , Adult , Female , Humans , Neck , Respiratory Tract Fistula/complications , Respiratory Tract Fistula/surgery , Treatment Outcome
11.
Singapore Med J ; 51(4): 311-4, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20505909

ABSTRACT

INTRODUCTION: Most differentiated thyroid carcinomas (DTC) are treated by total thyroidectomy in Hong Kong. This study investigates the outcome of tumour control in selected patients treated by hemithyroidectomy, which is beneficial in terms of having a lower operative morbidity. METHODS: This is a retrospective study of prospectively collected data from our cancer registry. Patients with pathologically proven differentiated thyroid carcinoma were stratified into risk groups according to the patients' age, tumour size, extrathyroid spread and distant metastasis. Low-risk patients were managed with hemithyroidectomy without postoperative radioactive iodine. Central compartment lymph node dissection was also carried out if the diagnosis was confirmed preoperatively. The oncological outcome and surgical morbidity were evaluated. RESULTS: A total of 236 patients with the diagnosis of DTC underwent a thyroidectomy at our institution during a 24-year period. 93 patients were initially treated by hemithyroidectomy. Subsequent evaluation was focused on this subgroup. The mean follow-up period was 63.3 +/- 55.1 months. The mean tumour diameter was 22.1 +/- 20.8 mm. The histopathologic diagnoses were papillary carcinoma (69 cases; 74.2 percent), follicular carcinoma (20 cases; 21.5 percent) and Hurthle cell carcinoma (four cases; 4.3 percent). 23 (24.7 percent) patients underwent hemithyroidectomy coupled with central compartment dissection. Pathologically proven lymph node metastasis was diagnosed in 12 (12.9 percent) patients. Transient vocal cord palsy occurred in six (6.5 percent) patients, while permanent vocal cord palsy occurred in two (2.2 percent). Local tumour recurrence arose in only one (1.1 percent) patient. No patient succumbed to the thyroid cancer. CONCLUSION: Hemithyroidectomy coupled with central compartment dissection in selected cases of DTC can achieve excellent tumour control with minimal surgical morbidity.


Subject(s)
Carcinoma/surgery , Thyroid Neoplasms/surgery , Thyroidectomy/methods , Adult , Carcinoma/therapy , Female , Follow-Up Studies , Hong Kong , Humans , Lymphatic Metastasis , Male , Medical Oncology/methods , Middle Aged , Registries , Retrospective Studies , Thyroid Neoplasms/therapy , Treatment Outcome
12.
Cancer Lett ; 277(1): 91-100, 2009 May 08.
Article in English | MEDLINE | ID: mdl-19138817

ABSTRACT

Human hepatocellular carcinoma (HCC) has an elevated requirement for arginine in vitro, and pegylated recombinant human arginase I (rhArg-PEG), an arginine-depleting enzyme, can inhibit the growth of arginine-dependent tumors. While supplementation of the culture medium with ornithine failed to rescue Hep3B cells from growth inhibition induced by rhArg-PEG, citrulline successfully restored cell growth. The data support the roles previously proposed for ornithine transcarbamylase (OTC) in the arginine auxotrophy and rhArg-PEG sensitivity of HCC cells. Expression profiling of argininosuccinate synthetase (ASS), argininosuccinate lyase (ASL) and OTC in 40 HCC tumor biopsy specimens predicted that 16 of the patients would be rhArg-sensitive, compared with 5 who would be sensitive to arginine deiminase (ADI), another arginine-depleting enzyme with anti-tumor activity. Furthermore, rhArg-PEG-mediated deprivation of arginine from the culture medium of different HCC cell lines produced cell cycle arrests at the G(2)/M or S phase, possibly mediated by transcriptional modulation of cyclins and/or cyclin dependent kinases (CDKs). Based on these results, together with further validation of the in vivo efficacy of rhArg-PEG against HCC, we propose that the application of rhArg-PEG alone or in combination with existing chemotherapeutic drugs may represent a specific and effective therapeutic strategy against HCC.


Subject(s)
Antineoplastic Agents/pharmacology , Arginase/pharmacology , Carcinoma, Hepatocellular/drug therapy , Cell Cycle/drug effects , Liver Neoplasms/drug therapy , Animals , Arginase/therapeutic use , Carcinoma, Hepatocellular/enzymology , Carcinoma, Hepatocellular/pathology , Cell Line, Tumor , Cell Proliferation/drug effects , Citrulline/metabolism , Citrullinemia/epidemiology , Cyclin-Dependent Kinase 2/analysis , Cyclins/analysis , Humans , Liver Neoplasms/enzymology , Liver Neoplasms/pathology , Mice , Ornithine Carbamoyltransferase Deficiency Disease/epidemiology , Recombinant Proteins/pharmacology , Xenograft Model Antitumor Assays
13.
Hong Kong Med J ; 14(1): 46-9, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18239243

ABSTRACT

OBJECTIVE: To study clinical perspectives pertaining to chronic sclerosing sialadenitis, which is also known as Kuttner's tumour. DESIGN: Retrospective medical chart review. SETTING: Regional hospital, Hong Kong. PATIENTS: From February 2005 to February 2007, nine cases with Kuttner's tumour were identified from our hospital electronic database. INTERVENTIONS: They underwent submandibular sialadenectomy under either local (n=6) or general (n=3) anaesthesia. MAIN OUTCOME MEASURES: The results of preoperative ultrasonography, fine-needle aspiration cytology, and intra-operative frozen section examination were correlated with the final diagnosis. Operative morbidity was also evaluated. RESULTS: The mean age of the patients at diagnosis was 61 years; three were females. Three had bilateral submandibular swellings. Following preoperative ultrasonography in six of the patients, tumours were suspected in two, an enlarged lymph node in one, and diffuse enlargement was visualised in the other three. Six patients had preoperative fine-needle aspiration cytology; five yielded scanty acini with normal-looking ductal cells, variable degrees of infiltration by chronic inflammatory cells without granuloma admixing fibrosis. In the sixth patient, only bland-looking epithelial cells, indicative of ductal differentiation suspicious of neoplasm were noted. Intra-operative frozen section examination was conducted in three patients: chronic inflammation without evidence of carcinoma was visualised in each. Operations performed under local anaesthesia were well tolerated; only one patient endured a transient, marginal facial nerve palsy. CONCLUSIONS: Kuttner's tumour is by no means rare. When supported by ultrasonography and fine-needle aspiration cytology, an accurate diagnosis can be made preoperatively and surgery can be reserved for symptomatic cases. Submandibular sialadenectomy is a safe and effective means of treating Kuttner's tumour, and can be accomplished under local anaesthesia.


Subject(s)
Carcinoma, Ductal/surgery , Salivary Gland Neoplasms/surgery , Sialadenitis/surgery , Submandibular Gland/surgery , Aged , Biopsy, Fine-Needle , Carcinoma, Ductal/pathology , Cohort Studies , Female , Humans , Male , Medical Audit , Middle Aged , Retrospective Studies , Salivary Gland Neoplasms/pathology , Sialadenitis/diagnostic imaging , Sialadenitis/pathology , Ultrasonography
14.
Hong Kong Med J ; 12(6): 473-6, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17148804

ABSTRACT

Tuberculous involvement of the oesophagus is rare, and is usually caused by direct spread from adjacent afflicted structures. We report an 83-year-old male patient with oesophageal tuberculosis secondary to tuberculous mediastinal lymphadenitis who presented with non-specific symptoms of anorexia and lethargy. Upper gastro-intestinal endoscopy revealed an ulcerative tumour-like lesion in the mid-oesophagus suggesting oesophageal carcinoma. Repeated endoscopic biopsies revealed a non-specific acute-on-chronic inflammation consisting of non-caseating granulomas, with no evidence of malignancy. Endoscopic ultrasonography demonstrated that the oesophageal lesion was secondary to direct extension of mediastinal lymphadenopathy. The diagnosis of tuberculosis was eventually confirmed by histological and microbiological analysis of a surgically excised cervical lymph node. The patient responded promptly to treatment with antituberculous drugs. We suggest that oesophageal tuberculosis has to be kept in mind in the differential diagnosis of oesophageal ulcerohypertrophic lesions.


Subject(s)
Esophageal Diseases/diagnosis , Esophageal Neoplasms/diagnosis , Tuberculosis/diagnosis , Aged , Aged, 80 and over , Diagnosis, Differential , Esophagus/pathology , Humans , Lymphangiectasis/pathology , Male
15.
Hong Kong Med J ; 11(5): 360-5, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16219955

ABSTRACT

OBJECTIVES: To examine the presentation, workup, and surgical complications of substernal goitre. DESIGN: Retrospective study. SETTING: Regional hospital, Hong Kong. PATIENTS: Twenty-four mostly elderly patients (mean age, 60.1 years) who underwent thyroidectomy for substernal goitres between 2000 and 2003 (substernal goitres were defined as those having either a caudal mass transgressing the fourth thoracic vertebra or having more than 50% of their overall mass residing within the thorax). MAIN OUTCOME MEASURES: Symptoms, histopathological diagnoses, morbidities, and complications. RESULTS: Dyspnoea was the most common symptom (n=8, 33%). Three (12.5%) patients presented with acute airway obstruction; however, 13 (54.2%) were asymptomatic apart from the presence of cervical masses. Computed tomographic scans were performed on all but two patients. Malignancy was present in 12.6% of patients, or 16.8% if occult papillary carcinoma is included. Partial or full sternotomies were performed in two (8.3%) patients. Complications included recurrent laryngeal nerve injury (n=1, 2.7% of nerves at risk), transient hypoparathyroidism (n=2, 13.3% of patients at risk), haematoma (n=1, 2.7%), pneumonia (n=1, 2.7%), and wound infection (n=1, 2.7%). There was no operative mortality or permanent hypoparathyroidism. The complication rate was significantly lower in the asymptomatic patients (P=0.033 by Fisher's exact test); clinicopathological parameters were otherwise statistically comparable between the two groups. CONCLUSIONS: There is rarely any mortality in thyroidectomy for substernal goitre, and the morbidity is also very low, especially in asymptomatic patients. In the absence of contra-indications, substernal goitre should be treated with early surgery rather than having it run the risk of acute airway distress or cancer.


Subject(s)
Goiter, Substernal/surgery , Thyroidectomy/methods , Adult , Aged , Aged, 80 and over , Chi-Square Distribution , Female , Humans , Male , Middle Aged , Postoperative Complications , Retrospective Studies , Thyroid Function Tests , Treatment Outcome
16.
Br J Surg ; 90(12): 1531-5, 2003 Dec.
Article in English | MEDLINE | ID: mdl-14648732

ABSTRACT

BACKGROUND: The aim of this study was to determine the predictive risk factors for complications resulting from foreign body ingestion. METHODS: A consecutive series of 1338 patients with suspected foreign body ingestion presenting from 1996 to 2000 were studied retrospectively. The potential risk factors for complications after foreign body ingestion were analysed by multivariate logistic regression and included concurrent medical illness, age, duration and types of symptoms, types of foreign body ingested, positive cervical radiographic findings and the level of foreign body impaction. RESULTS: Fish bone (62.7 per cent) was the commonest type of foreign body ingested. Most of the objects were impacted at or above the cricopharyngeus, the commonest site being the valleculae (31.4 per cent). Multivariate analysis showed that presentation delayed for more than 2 days (P < 0.001), positive cervical radiographic findings (P < 0.001) and foreign body impacted at the cricopharyngeus (P = 0.009) or upper oesophagus (P = 0.005) were significant independent risk factors associated with the development of complications after foreign body ingestion. CONCLUSION: In patients with a foreign body seen on plain cervical radiography, presentation delayed for more than 2 days after ingestion, and foreign body impacted at the level of the cricopharyngeus or oesophagus there is a high degree of correlation with the occurrence of complications. Awareness should be raised when these risk factors are present.


Subject(s)
Esophagus , Foreign Bodies/complications , Pharynx , Adolescent , Adult , Aged , Aged, 80 and over , Child , Deglutition , Endoscopy, Gastrointestinal , Female , Humans , Male , Middle Aged , Regression Analysis , Retrospective Studies , Risk Assessment , Risk Factors
17.
Hong Kong Med J ; 9(4): 293-4, 2003 Aug.
Article in English | MEDLINE | ID: mdl-12904619

ABSTRACT

Sialocele is an uncommon complication of parotidectomy. Most cases resolve after conservative therapy consisting of repeated aspiration and pressure dressing. The condition is, however, occasionally resistant to such therapy. We report on a 52-year-old Chinese man who had a 10-year history of right parotid swelling. Following fine-needle aspiration cytology, Warthin's tumour was diagnosed, but after elective parotidectomy, a swelling developed and parotid sialocele was diagnosed. Botulinum toxin type A was given after the sialocele had persisted for almost 3 weeks after surgery, and after conservative management had been tried; the sialocele disappeared after two doses of treatment. Botulinum toxin therapy was thus an effective method of treating persistent sialocele.


Subject(s)
Adenolymphoma/surgery , Botulinum Toxins, Type A/therapeutic use , Neuromuscular Agents/therapeutic use , Parotid Diseases/drug therapy , Parotid Gland/surgery , Postoperative Complications , Adenolymphoma/diagnosis , Humans , Male , Middle Aged , Parotid Diseases/pathology , Parotid Gland/pathology , Postoperative Complications/drug therapy
18.
Surg Endosc ; 17(6): 876-9, 2003 Jun.
Article in English | MEDLINE | ID: mdl-12618947

ABSTRACT

BACKGROUND: Transoral removal and sialoadenectomy are the two main modalities of treatment for submandibular stones. However, missed ductal stones are not uncommon, and there is a risk of lingual or hypoglossal nerve injury. We attempted to avoid these complications by using an endoscopic technique. METHODS: The case notes of the patients who had undergone endoscopic removal of submandibular stones were studied retrospectively. The procedure was performed under general anesthesia. The submandibular orifice was incised by carbon dioxide laser, and a 3.1-mm rigid scope was inserted under direct vision with normal saline irrigation after dilatation. The stones were either broken down by laser or removed with a Dormia basket or forceps. RESULTS: A total of 13 patients underwent the procedure. The duration of median follow-up was 15 months. In 11 patients, the stones were identified and removed. No stone was found in two patients (15.4%). There were no false negatives, since no stones were discovered subsequently in these two patients. One, two, three, and four stones were present inside the ducts in seven patients (54.6%), one patient (7.7%), two patients (15.4%), and one patient (7.7%), respectively. The symptoms subsided completely in 11 patients within 4 weeks after the procedure. Persistent swelling occurred in two patients. In one of them, no residual stone was revealed by CT scan. The other patient had a large calculus that was only partially fragmented by laser lithotripsy at the initial operation. No lingual nerve or hypoglossal nerve injury was detected in any patient. CONCLUSION: Sialoendoscopy is a safe and efficacious treatment for submandibular ductal stones. It reduces the incidence of missed stones, and nerve injury, as well as the need for sialoadenectomy.


Subject(s)
Endoscopy/methods , Salivary Duct Calculi/surgery , Submandibular Gland Diseases/surgery , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Retrospective Studies
19.
Int J Oral Maxillofac Surg ; 31(2): 212-8, 2002 Apr.
Article in English | MEDLINE | ID: mdl-12102423

ABSTRACT

Lymphoepithelioma-like carcinoma is a rare tumour in the oral cavity and is characterized histologically by non-keratinizing, undifferentiated squamous cell carcinoma with lymphocytic infiltration. Three consecutive cases of intraoral lymphoepithelioma-like carcinoma are reported. A review of the literature reveals a similar biological behaviour to that of nasopharyngeal lymphoepithelioma: a high incidence of cervical nodal spread and remarkable radiosensitivity. Chemotherapy should be considered when nodal or distant metastases are present. The association of the Epstein-Barr virus with this tumour remains unclear but our experience suggests a positive correlation in Chinese individuals.


Subject(s)
Carcinoma, Squamous Cell/pathology , Mouth Neoplasms/pathology , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/virology , Female , Herpesvirus 4, Human/isolation & purification , Hong Kong , Humans , Male , Mandibular Neoplasms/pathology , Mandibular Neoplasms/virology , Middle Aged , Mouth Neoplasms/virology , Palatal Neoplasms/pathology , Palatal Neoplasms/virology , Palate, Soft
20.
ANZ J Surg ; 71(11): 634-6, 2001 Nov.
Article in English | MEDLINE | ID: mdl-11736820

ABSTRACT

BACKGROUND: Acute diverticulitis of the caecum and ascending colon is uncommon. Controversies abound as regards the optimal surgical treatment, ranging from appendectomy, diverticulectomy to right hemicolectomy. The aim of the present paper was to review treatment strategy followed by a critical appraisal. METHODS: The case notes of 30 patients with acute diverticulitis of the right colon who were treated at the United Christian Hospital, Hong Kong from 1992 to 1998 were systematically reviewed. The data were subjected to statistical analysis. RESULTS: The median age was 34 years, with a male:female ratio of 1:1.15. All patients presented with acute right lower abdominal pain and localized rebound tenderness. All were diagnosed preoperatively as having appendicitis. The mean duration of symptoms was 2 days (range: 1-6 days). Two treatment groups were identified. Group A (n = 16; 53%) received appendicectomy alone, while group B (n = 14; 47%) underwent diverticulectomy in addition to appendicectomy, including one patient with perforated diverticulitis. Overall, there was no procedure-related morbidity or mortality. Both groups received a similar duration of broad-spectrum antibiotics. All the patients were interviewed by phone after operation to detect any recurrence of symptoms, with a median follow-up interval of 34 months (range: 11-78 months). There was no recurrence of symptoms in group A, which received appendicectomy and antibiotics. The only difference was operative time. CONCLUSION: For non-perforated diverticulitis of the right colon, appendicectomy and intravenous antibiotics without diverticulectomy is the preferred treatment strategy.


Subject(s)
Diverticulitis, Colonic/therapy , Acute Disease , Adult , Anti-Bacterial Agents/therapeutic use , Appendectomy , Appendicitis/diagnosis , Case-Control Studies , Diagnosis, Differential , Diverticulitis, Colonic/diagnosis , Diverticulitis, Colonic/surgery , Female , Humans , Male , Retrospective Studies
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