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Hepatoprotective activity of Phyllanthus reticulatus.

Das, Biplab K; Bepary, Sukumar; Datta, Bidyut K; Chowdhury, Ak Azad; Ali, Mohammad Shawkat; Rouf, Abu Shara Shamsur.

Pak J Pharm Sci ; 21(4): 333-7, 2008 Oct.

Article in English | MEDLINE | ID: mdl-18930851

ABSTRACT

Two partially purified organic fractions designated by PR1 and PR2 of the fat free ethanol (95%) extract of aerial parts of Phyllanthus reticulatus were tested for the hepatoprotective activity in rats against CCl(4)-induced liver damage. The rats receiving the fractions showed promising hepatoprotective activity as evident from significant changes of pentobarbital-induced sleeping time, changes in serum levels of sGPT, sGOT, sALP and bilirubin and also from histopathological changes as compared to CCl(4)-intoxicated rats.

Subject(s)

Euphorbiaceae , Liver Diseases/prevention & control , Liver/drug effects , Protective Agents/pharmacology , Animals , Biomarkers/blood , Carbon Tetrachloride , Chemical and Drug Induced Liver Injury , Disease Models, Animal , Euphorbiaceae/chemistry , Hypnotics and Sedatives/pharmacology , Liver/enzymology , Liver/pathology , Liver Diseases/metabolism , Liver Diseases/pathology , Male , Necrosis , Phenobarbital/pharmacology , Plant Components, Aerial , Protective Agents/isolation & purification , Rats , Rats, Long-Evans , Sleep/drug effects

ABSTRACT

Subject(s)

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