ABSTRACT
Hypothyroidism is a rare cause of pericardial effusion (PE). Pericardial effusion secondary to hypothyroidism remains a diagnostic challenge for clinicians because of its inconsistency between symptoms and amount of pericardial effusion. We report an atypical case that presented with ascites and was diagnosed to have cardiac tamponade secondary to primary hypothyroidism. Besides repeated pericardiocentesis she eventually required surgical management and optimization of medical therapy to manage the massive pericardial effusion.
Subject(s)
Cardiac Tamponade/etiology , Hypothyroidism/complications , Pericardial Effusion/etiology , Adult , Female , Humans , Hypothyroidism/diagnosisABSTRACT
A facile stereoselective synthesis of (Z)- and (E)-allyl sulfides has been accomplished from Morita-Baylis-Hillman acetates in one-pot by treatment with benzene thiol in the presence of catalytic amounts of 15% aqueous NaOH and TBAI in DMSO at room temperature. The method has been applied for the synthesis of (Z)-3-(4-methoxybenzylidene)thiochroman-4-one, a potent antifungal compound.
Subject(s)
Allyl Compounds/chemical synthesis , Allyl Compounds/pharmacology , Antifungal Agents/chemical synthesis , Antifungal Agents/pharmacology , Chromans/chemical synthesis , Acetates/chemistry , Catalysis , Chromans/pharmacology , Cyclization , Dimethyl Sulfoxide , Indicators and Reagents , Magnetic Resonance Spectroscopy , Sodium Hydroxide , Solvents , Spectrometry, Mass, Fast Atom Bombardment , Spectrophotometry, Infrared , Stereoisomerism , Sulfides/chemical synthesis , Sulfides/pharmacologyABSTRACT
An efficient and solely stereoselective synthesis of (E)-alpha-methylcinnamic acids has been accomplished in single pot by reduction of the unmodified Baylis-Hillman adducts, methyl-3-hydroxy-3-aryl-2-methylenepropanoates with I(2)/NaBH(4) reagent system at room temperature followed by hydrolysis. The efficacy of this method has been proved in the total synthesis of 1-[p-(myristyloxy)-alpha-methylcinnamoyl]glycerol, LK-903, a highly active hypolipidemic agent.
Subject(s)
Cinnamates/chemical synthesis , Glycerides/chemical synthesis , Hypolipidemic Agents/chemical synthesis , Molecular StructureABSTRACT
2-Benzoxepines have efficiently been synthesized from Morita-Baylis-Hillman adducts, alkyl 3-aryl-3-hydroxy-2-methylenepropanoates by treatment with HCHO catalyzed by silica supported perchloric acid (HClO4.SiO2) or Amberlyst-15 in CH2Cl2 under reflux for a short period of time (1.5-2.5 h). The catalyst can be recovered and recycled. The antibacterial properties of the new 2-benzoxepines were studied but no activity was found.
