ABSTRACT
Verrucous hemangioma or verrucous venous malformation is a superficial venous malformation frequently misdiagnosed as a lymphatic malformation because of its classical hyperkeratotic appearance. Clinical characteristics of VVM were studied in patients with a histologically confirmed VVM, and validated in a prospective study of 18 patients. VVM was made of separated vascular elements with irregular shape, in a linear disposition, with variable thickness and keratosis. Its specific vascular pattern consisting of an erythematous patch with scattered small red to violet dots was easily identified using dermoscopy. In many cases, the typical clinical presentation of verrucous hemangioma is sufficient to establish the diagnosis and a biopsy may not be required.
Subject(s)
Hemangioma/pathology , Skin Diseases, Vascular/pathology , Adolescent , Adult , Child , Child, Preschool , Dermoscopy/methods , Diagnosis, Differential , Diagnostic Errors , Female , Humans , Infant , Lymphatic Abnormalities/pathology , Male , Skin/pathology , Young AdultABSTRACT
Large congenital melanocytic naevi (LCMN) represent the main risk factor for development of melanoma in childhood. This retrospective study of 10 cases of melanoma in patients with LCMN used fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) (6 cases) to elucidate the clinical, histological, and cytogenetic characteristics of this rare disorder. Six melanomas were found within the LCMN, the others in lymph nodes, subcutis and brain. The LCMN was located on the trunk in 8 cases, with satellite naevi in 6 cases. Two distinct groups emerged: 5 melanomas that developed before the age of 10 years and the other after 20 years. The mortality rate was 60% and clearly correlated with clinical stage at diagnosis. Histological diagnosis was difficult in only 2 patients in whom neither immunohistochemistry nor FISH were helpful. Otherwise, CGH showed a high number of chromosomal aberrations leading to a formal diagnosis.
Subject(s)
Brain Neoplasms/pathology , Melanoma/pathology , Neoplasms, Second Primary/pathology , Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Adolescent , Adult , Axilla , Brain Neoplasms/genetics , Child , Child, Preschool , Comparative Genomic Hybridization , Female , Groin , Humans , In Situ Hybridization, Fluorescence , Infant , Ki-67 Antigen/analysis , Lymph Nodes/pathology , Lymphatic Diseases/genetics , Lymphatic Diseases/pathology , Male , Melanoma/genetics , Melanoma-Specific Antigens/analysis , Middle Aged , Neoplasms, Second Primary/genetics , Nevus, Pigmented/congenital , Nevus, Pigmented/genetics , Retrospective Studies , Skin Neoplasms/congenital , Skin Neoplasms/genetics , Young Adult , gp100 Melanoma AntigenABSTRACT
Precursor B-cell lymphoblastic lymphoma (B-LBL) is an uncommon high-grade neoplasm. Primary cutaneous B-LBL is uncommon and clinical diagnosis is difficult. We report two cases of primary cutaneous B-LBL that had initially been diagnosed as an infected dermoid cyst and lipoma, respectively, and referred for excision. The cases demonstrate the importance of biopsy and histopathologic examination of subcutaneous tumors to guide appropriate therapy.
