ABSTRACT
Aminoglycoside-induced renal toxicity is well known and may manifest with nonoliguric renal failure or renal tubular dysfunction. Aminoglycoside-induced renal tubular dysfunction could result in diffuse damage or manifest as a Fanconi-like syndrome, Bartter-like syndrome, or distal renal tubular acidosis. We discuss a patient who developed severe renal tubular dysfunction secondary to short-term therapy with Amikacin, resulting in refractory hypokalemia, hypocalcemia, hypomagnesemia, metabolic alkalosis, and polyuria. This constellation of biochemical abnormalities mimic Type 5 Bartter's syndrome, where there is activating mutation of the calcium sensing receptor in the thick ascending loop of Henle and the distal tubule. In this case this activation of the calcium sensing receptor was triggered by amikacin. This phenomenon has been described with gentamicin though never with amikacin. Recovery of the tubular dysfunction took 15 days following cessation of the offending drug, Amikacin.
Subject(s)
Amikacin/adverse effects , Anti-Bacterial Agents/adverse effects , Bartter Syndrome/chemically induced , Hypocalcemia/etiology , Adult , Amikacin/administration & dosage , Anti-Bacterial Agents/administration & dosage , Bartter Syndrome/diagnosis , Calcium/blood , Diagnosis, Differential , Fatal Outcome , Humans , Hypocalcemia/blood , Injections, Intravenous , Male , Severity of Illness Index , Urinary Tract Infections/drug therapyABSTRACT
We present a 13 year old girl from Assam who had been treated as abdominal tuberculosis for 2 years due to the presence of refractory lymphocyte-predominant ascites and multiple small bowel strictures associated with significant anorexia and weight loss. On evaluation she was found to have retroperitoneal fibrosis with hydroureteronephrosis, mediastinal fibrosis and a retro-orbital pseudotumour. Based on these findings the diagnosis of Multifocal Idiopathic Fibrosclerosis (MIFS) was made. Ascites and multiple bowel strictures have been only rarely been described in association with MIFS. The other unique features in this patient were the early age of presentation, the presence of mediastinal fibrosis in association with retroperitoneal fibrosis, extensive soft tissue fibrosis of the neck, axillae and the presence of trismus. In a country like ours where Tuberculosis is commonplace, one would not think twice about treating such a case with antituberculous therapy. However, with a constellation of findings suggestive of a diffuse fibrotic process, MIFS should be an important consideration.
Subject(s)
Peritonitis, Tuberculous/diagnosis , Retroperitoneal Fibrosis/diagnosis , Abdomen , Adolescent , Anti-Inflammatory Agents/therapeutic use , Diagnosis, Differential , Female , Fibrosis/diagnosis , Humans , Orbital Pseudotumor/diagnosis , Peritonitis, Tuberculous/drug therapy , Peritonitis, Tuberculous/pathology , Prednisolone/therapeutic use , Retroperitoneal Fibrosis/pathology , Sclerosis/diagnosisABSTRACT
The clinical presentation of hantavirus infections in India is unclear. We report here a case of hantavirus infection in a 46 year old quarry worker presenting with fever, abdominal pain, jaundice, thrombocytopenia and renal dysfunction. Seroconversion and rising anti-hantavirus IgG titers were taken as evidence of hantavirus infection. Clinicians should consider hantavirus infections in the differential diagnosis of acute febrile illness along with scrub typhus, leptospirosis and dengue.
