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1.
Ann Emerg Med ; 81(1): 84-94, 2023 01.
Article in English | MEDLINE | ID: mdl-35641354

ABSTRACT

STUDY OBJECTIVE: We aimed to assess the analgesic and anxiolytic efficacy of distraction, a nonpharmacologic intervention provided by 3-dimensional (3D) virtual reality (VR) compared with that provided by 2-dimensional (2D) VR during minor emergency department (ED) procedures. METHODS: This randomized controlled study conducted in the ED of a teaching hospital included patients aged more than or equal to 18 years undergoing minor procedures. The patients watched the same computer-generated VR world either in 3D in a head-mounted display (intervention) or in 2D on a laptop screen (control). Our main outcomes were pain and anxiety during the procedure, assessed on a 100-mm visual analog scale. Secondary outcomes included the impression of telepresence in the computer-generated world assessed using the Igroup Presence Questionnaire, and the prevalence and intensity of cybersickness measured on a 100-mm visual analog scale. RESULTS: The final analysis included 117 patients. The differences in median procedural pain and anxiety levels between the 2D and 3D VR groups were not significant: -3 mm (95% confidence interval [CI] -14 to 8) and -4 mm (95% CI -15 to 3), respectively; the difference in telepresence was 2.0 point (95% CI 0 to 2.0), and the proportion difference of cybersickness was -4% (95% CI -22 to 14), with an intensity difference of -5 mm (95% CI -9 to 3). CONCLUSION: During minor procedures in adult patients in the ED, distraction by viewing a 3D virtual world in a head-mounted VR display did not result in lower average levels of procedural pain and anxiety than that by 2D viewing on a screen despite a higher sense of telepresence. There were no significant differences in the prevalence and intensity of cybersickness between the 2 groups.


Subject(s)
Anti-Anxiety Agents , Pain, Procedural , Virtual Reality , Adult , Humans , Pain, Procedural/prevention & control , Analgesics , Anxiety/prevention & control , Emergency Service, Hospital
2.
J Clin Med ; 13(1)2023 Dec 21.
Article in English | MEDLINE | ID: mdl-38202053

ABSTRACT

BACKGROUND: The original description of boxer's knuckle injury of the fifth ray mentions that the injury occurs between the extensor digitorum communis (EDC) and the extensor digiti minimi (EDM). Subsequent reports claim similar findings. Anatomical studies show that the EDC of the fifth ray is absent in most patients, while the EDM is generally composed of two slips. We present a modification of the current description of boxer's knuckle injury of the little finger based on the correlation between advanced preoperative 3D imaging and intraoperative findings. METHODS: Five patients were investigated preoperatively using high-resolution ultrasound and 3D tendon reconstruction-based MR arthrography. Surgical exploration identified the lesion site relative to the EDM and EDC. RESULTS: All patients had two slips of the EDM and no EDC to the fifth ray. The injury appeared as a longitudinal tear of the EDM between its two slips. The mean gap was 7.8 mm (range 4.5-10 mm) on the pathological side vs. 1.3 mm (range 1-2 mm) on the healthy contralateral side. CONCLUSIONS: We believe that previous descriptions of boxer's knuckle of the fifth ray are inaccurate. High-resolution ultrasound and 3D reconstructions based on MR arthrography are reliable diagnostic tools allowing to locate the injury with precision.

3.
J Hand Surg Eur Vol ; 47(3): 264-269, 2022 03.
Article in English | MEDLINE | ID: mdl-34670438

ABSTRACT

We investigated the role of three-dimensional (3-D) CT in the diagnosis and management of four bipartite scaphoids in three patients. We computed the volume ratio, moment of inertia ratio and direction vector from the centroid of the scaphoid to the os centrale carpi. We found that the os centrale carpi was always smaller than the scaphoid and showed an elongated shape in the scaphoid longitudinal axis. Its position was always posterior compared with the scaphoid anteroposterior axis. The main morphological feature of bipartite scaphoids was the continuity of the scaphoid from its proximal to distal aspect along the longitudinal axis. These criteria from 3-D imaging should be considered useful in the diagnosis of bipartite scaphoid as it allows differentiation from nonunion. 3-D single-photon emission computed tomography (SPECT)/CT was helpful in the surgical decision-making when the patient was symptomatic. 3-D imaging was also used for the preoperative simulation and planning of bone fusion as it simplifies surgery and makes it more accurate. Here we provide clear criteria for diagnosing bipartite scaphoids and for the planning when surgery is deemed necessary.


Subject(s)
Scaphoid Bone , Tomography, X-Ray Computed , Arthrodesis , Humans , Imaging, Three-Dimensional , Scaphoid Bone/diagnostic imaging , Scaphoid Bone/surgery , Wrist , Wrist Joint/surgery
4.
Microsurgery ; 42(3): 226-230, 2022 Mar.
Article in English | MEDLINE | ID: mdl-34636060

ABSTRACT

BACKGROUND: Metacarpal nonunion is a rare condition. The osteogenic capacity of periosteal free flap was investigated in five patients with metacarpal nonunion and impaired bone vascularization. PATIENTS AND METHODS: Surgery was performed between 64 and 499 days after the initial bone osteosynthesis. The average age was 27.6 (range 16-32) years. Nonunion was caused by excessive periosteal removal in two patients, extensive open trauma in three. Four nonunions were diaphyseal, one metaphyseal. A periosteal medial femoral condyle free flap was raised on the descending genicular artery for four patients, the superomedial genicular artery for one. After osteosynthesis with a plate, the flap was wrapped around the metacarpal, overlapping the bone proximally and distally. The recipient vessel were the dorsal branch of the radial artery and a vena comitans in the anatomical snuffbox in four patients, at the base of the first webspace in one. RESULTS: The flap size ranged from 5 × 3.5 cm to 8 × 4 cm. No postoperative complication occurred. Radiological bone union was achieved 3 to 8 months after surgery. One patient had a full range of motion, one a slight extension lag of the proximal interphalangeal joint, two moderate joint stiffness of the proximal interphalangeal or metacarpophalangeal joint (one requiring plate removal and extensor tenolysis), one severe stiffness that allowed using a hook grip which was the aim of the surgery. CONCLUSION: In case of metacarpal nonunion with impaired bone vascularization, the periosteal medial femoral condyle free flap provides an effective and biomimetic approach to bone healing.


Subject(s)
Fractures, Ununited , Free Tissue Flaps , Metacarpal Bones , Adolescent , Adult , Femur/surgery , Fractures, Ununited/diagnostic imaging , Fractures, Ununited/surgery , Humans , Metacarpal Bones/surgery , Range of Motion, Articular , Young Adult
5.
Neurol Int ; 13(3): 469-476, 2021 Sep 14.
Article in English | MEDLINE | ID: mdl-34564291

ABSTRACT

BACKGROUND: Ulnar nerve compression at the elbow level is the second-most common entrapment neuropathy. The aim of this study was to use shear-wave elastography for the quantification of ulnar nerve elasticity in patients after ulnar nerve decompression with anterior transposition and in the contralateral non-operative side. METHOD: Eleven patients with confirmed diagnosis and ulnar nerve decompression with anterior transposition were included and examinations were performed on an AixplorerTM ultrasound system (Supersonic Imagine, Aix-en-Provence, France). RESULTS: We observed significant differences at 0-degree (p < 0.001), 45-degree (p < 0.05), 90-degree (p < 0.01) and 120-degree (p < 0.001) elbow flexion in the shear elastic modulus of the ulnar nerve in the operative and non-operative sides. There were no statistically significant differences between the elasticity values of the ulnar nerve after transposition at 0-degree elbow flexion and in the non-operative side at 120-degree elbow flexion (p = 0.39), or in the ulnar nerve after transposition at 120-degree elbow flexion and in the non-operative side at 0-degree elbow flexion (p = 0.09). CONCLUSION: Shear-wave elastography has the potential to be used postoperatively as a method for assessing nerve tension noninvasively by the estimation of mechanical properties, such as the shear elastic modulus.

6.
J Hand Surg Am ; 46(11): 1023.e1-1023.e7, 2021 11.
Article in English | MEDLINE | ID: mdl-33865656

ABSTRACT

PURPOSE: The spiral oblique retinacular ligament (SORL) procedure acts as a dynamic tenodesis to restore distal interphalangeal joint (DIP) extension and restrain proximal interphalangeal hyperextension. Despite the ingenious technique based on the oblique retinacular ligament anatomy, obtaining strong internal fixation remains an issue during the SORL procedure. We present a modified technique using the flexor digitorum profundus (FDP) hemi-tendon transfer. METHODS: We dissected 5 fresh cadaveric specimens to evaluate morphometric parameters of the SORL procedure using the hemi-FDP. The volar groove of the FDP tendon was identified in zone I of the flexor sheath and the tendon was divided into radial and ulnar bundles. The selected hemi-tendon was divided at the proximal edge of the A1 pulley and a SORL procedure was performed through a transosseous tunnel in the distal phalanx. This technique was used in 3 patients with swan neck deformity. RESULTS: The optimal distance between the DIP joint and the anterior drill hole of the transosseous tunnel was 7.6 mm (range, 6.8-8.5 mm). The relative loss of length of the tendon owing to the SORL path was 25.8 mm (range, 19.6-29.9 mm). In the clinical cases, the procedure improved DIP joint extension lag and prevented proximal interphalangeal joint hyperextension. Preserving one-half of the FDP allowed complete flexion of the DIP joint. CONCLUSIONS: The procedure is technically feasible. Its main advantages are that a distal suture is not required and that the substantial length of the tendon allows sturdy proximal internal fixation. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic V.


Subject(s)
Hand Deformities, Acquired , Tendon Transfer , Finger Joint/surgery , Humans , Ligaments , Tendons/surgery
7.
J Plast Reconstr Aesthet Surg ; 74(9): 2149-2155, 2021 Sep.
Article in English | MEDLINE | ID: mdl-33451945

ABSTRACT

PURPOSE: Recently, local anaesthesia has become popular among hand surgeons. We hypothesized that using the "wide awake local anaesthesia no tourniquet" (WALANT) approach would result in lower global costs and in an increase in the operating room (OR)'s efficiency. METHODS: All cases of carpal tunnel (CTR) and trigger finger releases (TFR) performed over 2016 and 2017 were divided into four groups, following which the anaesthesia method was used. Total OR occupation time, surgical time and the "all but surgery" time were analysed. A common minimum bill per anaesthesia was generated. RESULTS: WALANT or local anaesthesia and tourniquet increase the OR's throughput by having shorter operation room occupation times than other methods (17.5-33%). Costs of the two procedures are reduced by 21-31% when using local anaesthesia methods. CONCLUSION: Preferring those techniques for CTR and TFR has a notable beneficial impact on the costs and on the OR's efficiency. This effect is more evident on short surgical procedures. LOE: Level of evidence III, economic analysis.


Subject(s)
Anesthesia, Local/economics , Carpal Tunnel Syndrome/surgery , Hand/surgery , Health Care Costs , Operating Rooms/organization & administration , Trigger Finger Disorder/surgery , Anesthesia, Conduction/economics , Efficiency, Organizational , Humans , Nerve Block/economics , Operative Time , Tourniquets , Workflow
8.
Surg Radiol Anat ; 43(5): 721-726, 2021 May.
Article in English | MEDLINE | ID: mdl-33398519

ABSTRACT

PURPOSE: The flexor carpi radialis brevis (FCRB) is a supernumerary musculotendinous structure of the wrist that has been the focus of some interest in the last decade. While its anatomy is well known, its in vivo function remains unknown as it has never been studied. METHODS: Eleven cases of FCRB underwent a multimodal ultrasound consisting of B-mode, color Doppler and shear wave elastography. RESULTS: A pennate shape was observed in all cases and the mean value of the cross-sectional area was 0.8 cm2 (SD 0.3 cm2). Young's modulus was significantly (p < 0.01) different between the resting position and active flexion or passive extension. CONCLUSION: Our study demonstrates that the FCRB shows biomechanics of a typical skeletal muscle and is voluntarily controlled by flexing the wrist. Absent in other vertebrate taxa, the FCRB probably plays a role in active stability of the wrist in Human.


Subject(s)
Anatomic Variation , Forearm/abnormalities , Muscle, Skeletal/abnormalities , Wrist/abnormalities , Adult , Biomechanical Phenomena , Elasticity Imaging Techniques , Female , Forearm/diagnostic imaging , Forearm/physiopathology , Humans , Male , Middle Aged , Muscle, Skeletal/diagnostic imaging , Muscle, Skeletal/physiopathology , Ultrasonography, Doppler, Color , Wrist/diagnostic imaging , Wrist/physiopathology , Young Adult
9.
Pediatr Dermatol ; 38(1): 187-190, 2021 Jan.
Article in English | MEDLINE | ID: mdl-33247494

ABSTRACT

Epithelioid sarcoma is a rare soft-tissue tumor that occurs mainly in children and young adults. It typically presents as a subcutaneous or deep dermal mass in distal extremities. Due to its benign-appearing clinical presentation, infrequent occurrence, and histologic similarities with other pathologies, the diagnosis of epithelioid sarcoma in its early stages can be extremely difficult and can be easily confused with benign lesions such as warts or foreign body granuloma. In this paper, we report the case of a 12-year-old boy with a distal-type epithelioid sarcoma of the hand and wish to emphasize the difficulties of diagnosing this potentially lethal tumor both clinically and histologically.


Subject(s)
Papilloma , Sarcoma , Soft Tissue Neoplasms , Warts , Child , Diagnosis, Differential , Humans , Male , Sarcoma/diagnosis , Soft Tissue Neoplasms/diagnosis , Young Adult
11.
Plast Reconstr Surg Glob Open ; 6(4): e1714, 2018 Apr.
Article in English | MEDLINE | ID: mdl-29876166

ABSTRACT

Wide awake local anesthesia no tourniquet (WALANT) hand surgery is a rapidly growing in popularity. WALANT has been used by hand surgeons when operating on bones, tendons, ligaments, nerve entrapments. We offer a case report of the first case in the literature describing WALANT technique when performing trapeziometacarpal joint arthroplasty with prosthesis implantation. We offer technical points on how to perform this procedure and the advantages that are associated with using WALANT for prosthesis arthroplasty.

12.
J Neurosurg ; 128(4): 1235-1240, 2018 04.
Article in English | MEDLINE | ID: mdl-28621630

ABSTRACT

OBJECTIVE Chronic neuropathic pain after peripheral nerve injury is a major clinical problem. Its management is difficult, and therapeutic approaches vary and include oral medication, neurostimulation, and surgery. The aim of this study was to assess the adequacy of surgical nerve revision in a large series of patients with long-term follow-up. METHODS The authors reviewed the charts of 231 patients (335 nerve injuries) who experienced neuropathic pain after peripheral nerve injury and underwent surgery for nerve revision at the authors' institution between 1997 and 2012. The following parameters were recorded for each patient: history, location, duration, and severity of the pain and details of nerve revision surgery. In addition, patients were invited to participate in a follow-up consultation and were asked to score their pain at that time. Current medications and examination findings were also documented. RESULTS Elective surgery was the source of nerve injury for 55.4% of the patients. The lower extremity was the most commonly involved anatomical region (54.3%), followed by the lower abdomen (16.4%) and the thoracic region (13%). The mean time between the onset of injury and revision surgery was 48 months. On average, 1.3 injured nerves per patient were explored, and surgery was performed 1.2 times per patient. Each nerve underwent revision 1.1 times on average. Neuromas-in-continuity and scar-tethered nerves were observed in 205 nerves (61%) and terminal neuromas were observed in 130 nerves (39%). The authors performed 186 (56%) neurolyses and 149 (44%) neuroma resections and translocations. The mean follow-up of the 127 (55%) patients who agreed to come back for a consultation was 68 months. These patients indicated an average pain decrease of 4 points in the visual analog scale (VAS) score. Pain relief greater than a 2-point decrease on the VAS, a criterion for a successful treatment according to the European Federation of Neurological Societies guidelines, was encountered in 80% of patients. Pain relief did not vary in a statistically significant way with regard to surgical technique, age and sex of the patient, affected nerve, or time between trauma and surgery. Before surgery, 76% of the patients were on a regimen of paracetamol and/or NSAIDs and 44% received opiates, while after nerve revision only 37% still required simple analgesia and 14% needed opiates. CONCLUSIONS Bearing in mind that medication achieves satisfying pain relief in only 30%-40% of patients with neuropathic pain, surgery must be considered as an effective alternative therapy. No objective criteria were shown to be factors of poor prognosis. Systematic preoperative clinical mapping of the injured nerves and diagnostic nerve blocks could improve the primary success rate of the surgery.


Subject(s)
Cancer Pain/surgery , Chronic Pain/surgery , Neuralgia/surgery , Neuroma/complications , Peripheral Nerve Injuries/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Cancer Pain/etiology , Chronic Pain/etiology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Neuralgia/etiology , Neurosurgical Procedures , Peripheral Nerve Injuries/etiology , Peripheral Nerves/surgery , Prognosis , Retrospective Studies , Young Adult
13.
Case Rep Orthop ; 2016: 6837298, 2016.
Article in English | MEDLINE | ID: mdl-27656304

ABSTRACT

Closed tendon avulsion of both flexor tendons in the same finger is an extremely rare condition. We encountered the case of a patient who presented a rupture of the flexor digitorum profundus in zone 1 and flexor digitorum superficialis in zone 3 in the little finger. This occurrence has not been reported previously. We hereby present our case, make a review of the literature of avulsion of both flexor tendons of the same finger, and propose a treatment according to the site of the ruptures.

14.
J Reconstr Microsurg ; 31(3): 187-90, 2015 Mar.
Article in English | MEDLINE | ID: mdl-25360859

ABSTRACT

BACKGROUND: Ulnar nerve decompression at the elbow traditionally requires regional or general anesthesia. We wished to assess the feasibility of performing ulnar nerve decompression and transposition at the elbow under local anesthesia. METHODS: We examined retrospectively the charts of 50 consecutive patients having undergone ulnar nerve entrapment surgery either under general or local anesthesia. Patients were asked to estimate pain on postoperative days 1 and 7 and satisfaction was assessed at 1 year. RESULTS: On day 1, pain was comparable among all groups. On day 7, pain scores were twice as high when transposition was performed under general anesthesia when compared with local anesthesia. Patient satisfaction was slightly increased in the local anesthesia group. These patients were significantly more willing to repeat the surgery. CONCLUSION: Ulnar nerve decompression and transposition at the elbow can be performed under local anesthesia without added morbidity when compared with general anesthesia.


Subject(s)
Decompression, Surgical/methods , Elbow/innervation , Patient Satisfaction , Ulnar Nerve Compression Syndromes/surgery , Ulnar Nerve/transplantation , Adult , Aged , Anesthesia, Local , Female , Humans , Male , Middle Aged , Pain, Postoperative/epidemiology
15.
J Hand Surg Am ; 38(10): 2009-15, 2013 Oct.
Article in English | MEDLINE | ID: mdl-24021736

ABSTRACT

Thumb hypoplasia treatment requires considering every component of the maldevelopment. Types II and IIIA hypoplasia share common features such as first web space narrowing, hypoplasia or absence of thenar muscles and metacarpophalangeal joint instability. Many surgical techniques to correct the malformation have been described. We report our surgical strategy that includes modifications of the usual technique that we found useful in reducing morbidity while optimizing the results. A diamond-shape kite flap was used to widen the first web space. Its design allowed primary closure of the donor site using a Dufourmentel flap. The ring finger flexor digitorum superficialis was transferred for opposition transfer, and the same tendon was used to stabilize the metacarpophalangeal joint on its ulnar and/or radial side depending on a uniplanar or more global instability. An omega-shaped K-wire was placed between the first and second metacarpals to maintain a wide opening of the first web space without stressing the reconstructed ulnar collateral ligament of the MCP joint. We report a clinical series of 15 patients (18 thumbs) who had this reconstructive program.


Subject(s)
Plastic Surgery Procedures/methods , Thumb/abnormalities , Thumb/surgery , Child , Female , Humans , Male , Range of Motion, Articular , Surgical Flaps , Treatment Outcome
16.
Tech Hand Up Extrem Surg ; 17(2): 120-2, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23689862

ABSTRACT

The surgical handling of central cleft hands may involve various procedures to restore acceptable function. Stabilization of the merged cleft is usually achieved through reconstruction of the intermetacarpal ligament. However, no attention has been paid to the agenesis of the metacarpophalangeal collateral ligaments adjacent to the cleft, which is responsible for an excessive laxity of the joint in the frontal plane. We propose an autologous ligamentoplasty aimed at stabilizing the metacarpophalangeal joint while taking into account the specificities of the immature skeleton. A tendon graft is harvested and passed in a figure-of-eight manner around the base of the proximal phalanx and the corresponding metacarpal neck. No transosseous tunnels or bone anchors are used, as these might result in growth plate injury. As the graft does not have any fixed bony attachment, it is free to glide throughout growth, therefore avoiding the occurrence of progressive overtightening.


Subject(s)
Collateral Ligaments/surgery , Hand Deformities, Congenital/surgery , Metacarpophalangeal Joint/surgery , Child , Humans , Tendon Transfer
17.
Rev Med Suisse ; 9(411): 2385-9, 2013 Dec 18.
Article in French | MEDLINE | ID: mdl-24693589

ABSTRACT

Management of musculoskeletal tumours usually begins with the appearance of a lump or bump, or the onset of unspecific symptoms. A poor initial work-up, a faulty biopsy or an inadequate resection may have a severe impact on the prognosis, including re-interventions, amputation, local recurrence or systemic spread of the disease. The patient with a suspicious lesion should be referred to a "sarcoma centers" where a planned and well-performed diagnostic work-up will allow a precise diagnosis in terms of histology and staging. After a multidisciplinary discussion of the case, an accurate treatment plan is established. Such an approach allows an adequate patient management, often with a positive impact on the survival and functional outcome.


Subject(s)
Bone Neoplasms/diagnosis , Muscle Neoplasms/diagnosis , Patient Care Team , Biopsy , Bone Neoplasms/therapy , Diagnostic Imaging , Humans , Muscle Neoplasms/therapy , Neoplasm Grading , Neoplasm Staging
18.
Skin Res Technol ; 18(4): 456-61, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22332947

ABSTRACT

BACKGROUND: Deep burn assessment made by clinical evaluation has an accuracy varying between 60% and 80% and will determine if a burn injury will need tangential excision and skin grafting or if it will be able to heal spontaneously. Laser Doppler Imaging (LDI) techniques allow an improved burn depth assessment but their use is limited by the time-consuming image acquisition which may take up to 6 min per image. METHODS: To evaluate the effectiveness and reliability of a newly developed full-field LDI technology, 15 consecutive patients presenting with intermediate depth burns were assessed both clinically and by FluxExplorer LDI technology. Comparison between the two methods of assessment was carried out. RESULTS: Image acquisition was done within 6 s. FluxEXPLORER LDI technology achieved a significantly improved accuracy of burn depth assessment compared to the clinical judgement performed by board certified plastic and reconstructive surgeons (P < 0.05, 93% of correctly assessed burns injuries vs. 80% for clinical assessment). CONCLUSION: Technological improvements of LDI technology leading to a decreased image acquisition time and reliable burn depth assessment allow the routine use of such devices in the acute setting of burn care without interfering with the patient's treatment. Rapid and reliable LDI technology may assist clinicians in burn depth assessment and may limit the morbidity of burn patients through a minimization of the area of surgical debridement. Future technological improvements allowing the miniaturization of the device will further ease its clinical application.


Subject(s)
Burns/diagnosis , Image Enhancement/instrumentation , Image Enhancement/methods , Laser-Doppler Flowmetry/instrumentation , Laser-Doppler Flowmetry/methods , Skin/injuries , Skin/pathology , Adolescent , Adult , Aged , Equipment Design , Equipment Failure Analysis , Humans , Middle Aged , Reproducibility of Results , Sensitivity and Specificity , Young Adult
19.
Eur J Neurosci ; 26(5): 1109-17, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17767490

ABSTRACT

Accelerating axonal regeneration to shorten the delay of reinnervation and improve functional recovery after a peripheral nerve lesion is a clinical demand and an experimental challenge. We developed a resorbable nerve conduit (NC) for controlled release of glial cell line-derived neurotrophic factor (GDNF) with the aim of assessing motor functional recovery according to the release kinetics of this factor in a short gap model. Different types of resorbable NCs were manufactured from a collagen tube and multiple coating layers of poly(lactide-coglycolide), varying in poly(lactide-coglycolide) type and coating thickness to afford three distinct release kinetics of the neurotrophic factor. GDNF release was quantified in vitro. End-to-end suture and GDNF-free NC served as controls. Thirty-five Wistar rats underwent surgery. Motor recovery was followed from 1 to 12 weeks after surgery by video gait analysis. Morphometrical data were obtained at mid-tube level and distal to the NC. NCs were completely resorbed within 3 months with minimal inflammation. GDNF induced a threefold overgrowth of fibers at mid-tube level. However, the number of fibers was similar in the distal segment of all groups. The speed of recovery was inversely proportional to the number of fibers at the NC level but the level of recovery was similar for all groups at 3 months. The resorbable conduits proved their ability to modulate axonal regrowth through controlled release of GDNF. In relation to the dose delivered, GDNF strikingly multiplied the number of myelinated fibers within the NC but this increase was not positively correlated with the return of motor function in this model.


Subject(s)
Absorbable Implants , Drug Delivery Systems/methods , Glial Cell Line-Derived Neurotrophic Factor/administration & dosage , Peroneal Neuropathies/physiopathology , Peroneal Neuropathies/therapy , Recovery of Function/drug effects , Animals , Axons/drug effects , Axons/pathology , Axons/ultrastructure , Male , Nerve Regeneration/drug effects , Peroneal Neuropathies/pathology , Rats , Rats, Wistar , Time Factors
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