Syndrome of the trephined: A rare challenge in head & neck reconstruction.

BACKGROUND: Syndrome of the trephined (ST) refers to the rare, reversible event of neurological deterioration following craniectomy. ST is also known as "sinking skin flap syndrome" and typically occurs in the weeks to months following operation. The mechanism underlying syndromic onset is poorly understood. Changes to cerebrospinal fluid flow, alteration of temperature-related perfusion, and scarring at the intracranial surgical site have all been proposed. Patients present with a variety of symptoms related to paradoxical increased intracranial pressure. Sometimes falsely attributed as a consequence of the initial cranial insult, ST is more specifically a symptomatic process resulting as direct consequence of the craniectomy procedure. With timely identification and subsequent cranioplasty, the associated neurological dysfunction can be corrected - this rectification being the primary confirmatory feature of the syndrome. CASE: A 59-year-old female was seen with regards to a wound of the temporoparietal scalp, with exposed cranial implant. She had suffered a traumatic brain injury and underwent craniectomy after a motor vehicle accident 10 years prior. Her injury was complicated by necrosis of her cranial bone flap after reimplantation and at least 10 subsequent attempts to reconstruct her wound. When delayed cranial reconstruction was attempted on two separate occasions, the patient suffered severe syndrome of the trephined and required hospitalization for symptoms of impending herniation. Ultimately, she required revision and replacement of titanium mesh and latissimus dorsi free flap for soft tissue coverage of the titanium mesh. CONCLUSION: This case presents a unique surgical challenge in that chronic infection was perpetuated by the replacement of implant material in the wound. Soft tissue reconstruction alone was not possible given the patient's severe ST. Free tissue transfer was required in order to bring vascularized myofascial tissue to prevent recolonization of the newly implanted mesh and allow the cranial wound to heal.

Injection and sexual risk among people who use or inject drugs in Kampala, Uganda: An exploratory qualitative study.

BACKGROUND: Countries in Sub-Saharan Africa (SSA) have seen rapid increases in injection drug use since 2008. In Uganda, the Global Sate of Harm report and studies conducted by Makerere University Crane Surveys have estimated HIV prevalence among people who inject drugs (PWID) at approximately 17%. The objective of the research was to document injection and other drug-related risks among people who use drugs in Uganda to develop comprehensive HIV/HCV prevention interventions. METHODS: Between August and September 2018, we conducted qualitative interviews among male and female people who use drugs. Interview topics included the availability and accessibility of clean syringes, injection risks, overdose, sexual-risk behaviors, and the availability and accessibility of harm reduction and drug treatment services. RESULTS: Participants reported several injection-related risks including sharing and reusing syringes, pooling and mixing drugs in the same container, measuring drugs using syringes, getting prefilled injections from dealers, being injected by other people who inject drugs, and using contaminated water or blood to dilute drugs. Participants reported a scarcity of harm reduction services, although a few appear to have participated in the syringe exchange pilot conducted by the Uganda Harm Reduction Network (UHRN). Even fewer reported knowing organizations that helped people who use drugs abstain from or reduce their use. Medication assisted therapy (MAT) and naloxone to reverse overdoses are not currently available. CONCLUSIONS: Comprehensive prevention and treatment services are needed in Uganda and should include expanded syringe exchange programs, social network HIV testing, HCV testing, provision of naloxone and MAT, and linkage to and retention in HIV care.

Corrigendum to "Vertebral Arteriovenous Fistula: An Unwelcome Thrill".

[This corrects the article DOI: 10.1155/2017/8386459.].

Vertebral Arteriovenous Fistula: An Unwelcome Thrill.

Cervical vertebral AV fistulae are uncommon vascular lesions involving abnormal communication between the extradural vertebral artery and surrounding venous structures. We examine the case of a female evaluated in the emergency department with a vertebral AV fistula presenting classically as pulsatile tinnitus and later successfully treated with standard endovascular techniques. A discussion on the etiology, pathophysiology, and management of vertebral AV fistulae follows.