[18 months long-term analysis of effectiveness, safety and tolerance of sumatriptan s.c. in acute therapy of migraine attacks]. / Achtzehnmonatige Langzeitanalyse der Wirksamkeit, Sicherheit und Verträglichkeit von Sumatriptan s.c. in der Akuttherapie von Migräneanfällen.

The aim of the open prospective study was to investigate the efficacy, safety and tolerability of subcutaneous sumatriptan in acute migraine treatment. Patient self-treatment was monitored over a time period of 6-18 months with 6 mg of sumatriptan administered subcutaneously by an autoinjector. In total, 2,263 patients participated in the study. Headache intensity was documented by the patient in a headache diary before and 1 and 2 h after application. During the study period from October 1991 to June 1993, 43,691 migraine attacks were investigated. Treatment with sumatriptan was efficient in 89.5% of the attacks. Headache relief was achieved in 71%. Headache reoccurred in 22.7% of the attacks, and therefore a second injection was administered. An intraindividual treatment efficacy of 80-100% was achieved in 82.9% of the patients. During long-term treatment the ratio of effective treatment and headache frequency was constant; 4.9% of the patients withdrew from the study because of adverse events and because they felt the treatment was not effective. A total of 44.5% of the patients reported adverse events that were serious in 1.7%. Subcutaneous self-treatment with sumatriptan in the acute treatment of migraine is effective and well tolerated by the patients.

[Algesimetric experiment on pain sensitivity in the pericranial musculature. Circadian rhythms and corresponding psychic variables.]. / Die schmerzempfindlichkeit der perikranialen muskulatur im algesimetrischen experiment : Zirkadiane Rhythmik und korrespondierende psychische Variablen.

Many types of headache that occur in the form of attacks show a notably high incidence at certain times of the day. Attacks are often accompanied by emotional instability, irritability, exhaustion and other impairments of well-being. The cause for the frequent daytime occurrence of attacks is not clear. One possible explanation could be the variability in a person's sensitivity to headache over the course of the day. For this reason we set out to investigate whether pain sensitivity to experimentally-induced headache varies in a circadian manner and whether this variation correlates to changes in the current state of well-being over the course of the day. In 24 healthy, voluntary subjects, headache was induced experimentally at 0200, 0600, 1000, 1400, 1800, and 2200 hours. Blood criculation in both superficial temporal and occipital arteries was reduced by applying a cuff to the head and inflating it to 200 mmHg, thereby producing a continuously increasing, bilateral, dull, frontal headache. The subjects scaled the intensity continually, using the category subdividing procedure ranging from pain threshold to pain tolerance level. In addition, 17 dimensions of the current state of well-being and 12 personality traits were recorded at the above-mentioned times in a standardized quantitative manner. At low levels of headache intensity there were no significant differences in pain sensitivity. Sensitivity to very intense headache, however, varied significantly over the course of the day: sensitivity was greatest at 0200 hours; it decreased at a constant rate until 1400 hours, and increased again continuously until 2200 hours (P