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Bioorg Med Chem Lett
; 15(18): 4097-9, 2005 Sep 15.
Article
in English
| MEDLINE
| ID: mdl-16005211
ABSTRACT
Enamine-containing analogues of heteroarylquinones were prepared based on initial screening data observed against Mycobacterium tuberculosis H37Rv (Mtb). Several analogues showed moderate to good inhibitory activity, with one analogue (7) also demonstrating acceptable toxic selectivity (MIC 0.39 microg/mL, SI 15). Activity towards a range of single-drug-resistant strains of Mtb was suggestive of a novel mechanism of action for 7.