ABSTRACT
A new series of complexes of the type [Cu(dien)(2a-2tzn)Y(2)] and [Cu(dienXX)(2a-2tzn)Y(2)], where dien=diethylenetriamine and dienXX=Schiff dibase of diethylenetriamine formed with 2-furaldehyde (dienOO), 2-thiophenecarboxaldehyde (dienSS), or pyrrol-2-carboxaldehyde (dienNN); Y=Cl, Br or NO(3); and 2a-2tzn=2-amino-2-thiazoline, were synthesized and their structure established by C, H, N and Cu analysis; IR and electronic spectra; magnetic susceptibility; and molar conductivity. The isolated complexes are monomers, paramagnetic, and electrolytes of types 1:1 or 1:2. In both types of solid state complexes, [Cu(dien)(2a-2tzn)Y(2)] and [Cu(dienXX)(2a-2tzn)Y(2)], dien and its Schiff dibases are bonded to Cu(II) in a tridentate fashion through 3N atoms. The coordination sphere is completed by the endocyclic nitrogen of the thiazoline moiety and by two Cl, Br, or NO(3) groups with distorted octahedral geometry. The proposed structure of these compounds was supported by X-ray analysis of [Cu(dien)(Br)(2a-2tzn)](Br)(H(2)O). The coordination polyhedron around the copper atom can be described as a distorted square pyramid [Cu(dien)(Br)(2a-2tzn)](+). Its basal plane is occupied by the four nitrogen atoms of the dien and thiazoline ligands with Cu-N distances ranging between 1.996(6) and 2.032(3)A, and the axial position is occupied by one of the two bromine atoms (Br1) with a Cu1-Br1 bond distance of 2.782(1)A. The second bromine atom (Br2) is 4.694(2)A from the copper atom, which exists as a discrete anion and is responsible for the cationic nature of the complex. Results regarding toxicity, antitumor, and anti-inflammatory activities of the investigated compounds are promising and allow the selection of a lead compound for further biological studies.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Antineoplastic Agents/pharmacology , Copper/pharmacology , Heterocyclic Compounds/pharmacology , Polyamines/pharmacology , Schiff Bases/pharmacology , Thiazoles/pharmacology , Animals , Anti-Inflammatory Agents, Non-Steroidal/chemistry , Anti-Inflammatory Agents, Non-Steroidal/toxicity , Antineoplastic Agents/chemistry , Antineoplastic Agents/toxicity , Copper/toxicity , Crystallography, X-Ray , Female , Heterocyclic Compounds/chemistry , Heterocyclic Compounds/toxicity , Inflammation/drug therapy , Leukemia, Lymphoid/drug therapy , Ligands , Male , Mice , Mice, Inbred C57BL , Mice, Inbred DBA , Polyamines/toxicity , Rats , Schiff Bases/toxicity , Spectrophotometry, Infrared , Thiazoles/toxicityABSTRACT
The title compound, [Cu4Cl6O(C4H7NS)4], was obtained by the reaction of CuCl2*2H2O with 2-methyl-2-thiazoline in methanol. The complex has twofold crystallographic symmetry and contains a tetrahedron of four Cu(II) atoms coordinating a central mu4-O atom, with the six edges of the tetrahedron bridged by Cl atoms. Distance ranges are Cu-O 1.917 (4)-1.920 (4) and Cu-Cl 2.370 (2)-2.445 (2) A.
