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Lydiamycins A-D: cyclodepsipetides with antimycobacterial properties.

Huang, Xueshi; Roemer, Ernst; Sattler, Isabel; Moellmann, Ute; Christner, Arnulf; Grabley, Susanne.

Angew Chem Int Ed Engl ; 45(19): 3067-72, 2006 May 05.

Article in English | MEDLINE | ID: mdl-16619323

Subject(s)

Antibiotics, Antitubercular/pharmacology , Depsipeptides/chemistry , Depsipeptides/pharmacology , Mycobacterium/drug effects , Biological Products/pharmacology , Microbial Sensitivity Tests , Molecular Structure

Structure determination of germacrane-type sesquiterpene alcohols from an endophyte Streptomyces griseus subsp.

Guan, Shuhong; Grabley, Susanne; Groth, Ingrid; Lin, Wenhan; Christner, Arnulf; Guo, Dean; Sattler, Isabel.

Magn Reson Chem ; 43(12): 1028-31, 2005 Dec.

Article in English | MEDLINE | ID: mdl-16170856

ABSTRACT

Three germacrane-type sesquiterpene alcohols were isolated from an endophyte of mangrove plant Kandelia candel. Their structures were characterized as 1(10)E,5E-germacradiene-11-ol (1), 1(10)E,5E-germacradiene-3,11-diol (2), 1(10)E,5E-germacradiene-2,11-diol (3) based on the extensive NMR studies. Among them, 2 and 3 are identified as new compounds.

Subject(s)

Alcohols/chemistry , Rhizophoraceae/microbiology , Sesquiterpenes, Germacrane/chemistry , Streptomyces griseus/chemistry , Streptomyces griseus/classification , Alcohols/isolation & purification , Magnetic Resonance Spectroscopy , Molecular Structure , Sesquiterpenes, Germacrane/isolation & purification , Streptomyces griseus/physiology

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