Bird ownership and pulmonary outcomes apart from hypersensitivity pneumonitis in European older adults.

BACKGROUND: Exposure to birds has been linked with several lung pathologies and especially hypersensitivity pneumonitis, but discordant literature exist on the potential effects of this exposure on other respiratory pathologies. AIM: This study aims to examine the associations between bird ownership and asthma, lung cancer, and chronic obstructive pulmonary disease (COPD) in older European adults. METHODS: A total of 28,109 participants from the Survey of Health, Ageing, and Retirement in Europe were employed and analyzed with multivariate logistic regressions. RESULTS: No association was found with asthma or lung cancer. Bird ownership increased the odds for COPD diagnosis (OR=1.30; 95 % CI: 1.12-1.51) and more so in males (OR=1.53; 95 % CI: 1.25-1.87) after adjustment for demographic, respiratory, lifestyle, and socioeconomic factors. Male bird owners who smoke had an even more increased risk compared to non-smokers, as did those who lived in multi-person households compared to those living alone. CONCLUSION: Bird ownership may be positively associated with COPD in older European males.

Associations between lockdown intensity and suicide mortality in US states.

The COVID-19 pandemic, along with oppressive government interventions, placed a heavy burden on mental health. Suicide mortality is an outcome that may have been affected by the stringency of these lockdown measures. The aim of this study is to examine the association between lockdown intensity, measured by the Stringency Index, and suicide mortality rates in US states from March 2020 to December 2021. To this end, Bayesian methods were used for the estimation of the association for the total population, as well as by gender, and by race. Results show a small negative association between lockdown intensity and suicide mortality rates which applies to most of the examined populations. Future research will determine if this relationship remains the same after the pandemic.

Religion and survival among European older adults.

There are several pathways through which religion can affect longevity. Previous research, predominately from North America, has shown decreased mortality risk for participants that attended religious services. This study aims to examine the association between religion and all-cause mortality in a large sample of older European adults, comparing religious affiliations, and using prayer frequency as well as frequency of participation in a religious organisation as measures of religiousness. To this end, a total of 16,062 participants from the Survey of Health Ageing and Retirement in Europe were employed for a survival analysis (median follow-up 11.3 years; 3790 recorded deaths). Following a religion was negatively associated with mortality regardless of demographic and socioeconomic factors (HR = 0.81; 95% CI 0.74-0.89). Large differences in the median survival of participants from different religious affiliations can be mostly attributed to demographic and socioeconomic factors. Both frequency of prayer and religious participation exhibited a significant positive dose-response relationship with survival despite adjustments, although the results for religious participation were more profound. Changes on the religiosity levels of the European population will require additional research on the subject in the future.

Associations between Gun Ownership and Firearm Homicide Rates in US States.

The United States combine high rates of firearm homicides with high gun prevalence. In the past, a significant positive association was found between the two. This study revisits the gun prevalence-gun homicide debate using more elaborate estimates of gun ownership for the 50 States. Longitudinal data (1999-2016) were analysed with Bayesian multilevel Gamma-Poisson models. The results demonstrated a very small positive association that diminished after adjusting for crime rates. Findings suggest that the association either attenuated in more recent years, or previous studies had overestimated this association.

Pet ownership and survival of European older adults.

With pet ownership on the rise, millions of individuals are exposed to this environmental exposure. Although the subject has been largely studied, more evidence is needed to clarify the potential association of pet ownership with human health. The aim of this research is to study the potential association of pet exposure (any pet, cat, dog, bird, fish) with all-cause, cardiovascular and cancer mortality of older ( ≥  50 years) European residents. To this end, a total of 23,274 participants from the Survey of Health Ageing and Retirement in Europe (SHARE) were employed (median follow-up 119 months). All-cause mortality (5163 events), as well as cardiovascular (CVD) (1832 events), and cancer mortality (1346 events) were examined using Cox Proportional Hazards models for their relation with pet exposure at baseline. Stratified analyses were also performed by gender and for single or multi-person households. No significant association was observed for any of the pets with all-cause mortality on the whole sample and the fully adjusted models. In stratified analyses, bird exposure significantly increased the risk of all-cause mortality in women [Hazard Ratio ( HR ) = 1.23 ; 95% CI 1.04-1.44] as well as women living alone ( HR = 1.38 ; 95% CI 1.02-1.85). Cause-specific models revealed an increased risk of death for women bird owners for causes other than cancer and CVD ( HR = 1.40 ; 95% CI 1.05-1.99). In conclusion, bird ownership may be negatively associated with survival of older women in Europe.

The role of pre-pandemic teleworking and E-commerce culture in the COVID-19 dispersion in Europe.

The threats of the coronavirus have shifted the workplace of many people from office to home and also made e-commerce the primary medium for purchases. While these changes were made in an effort to mitigate contagion, there are no studies, to the best of our knowledge, that address if teleworking and e-commerce culture prior to the pandemic influenced the dispersion of the virus. In our study we examine whether pre-existing teleworking practices and e-commerce activity have played an important role in the COVID-19 dispersion in Europe. Based on a set of data from all European countries, the present study employs the Philips & Sul methodology to explore corona convergence patterns. Our findings suggest that pre-existing e-commerce activity and teleworking practices had little to no effect in reducing the initial opportunities of individuals to contract the virus leading to the conclusion that other social interactions must have played a more important role.

Polycythemia Vera in a Patient With Heterozygous Beta-Thalassemia: Coincidence or Causal Relationship?

Polycythemia vera (PV) and heterozygous beta-thalassemia (HBT) have opposing effects on the hematocrit (Hct) and may mask the presence of each other. Missing the diagnosis of PV may have serious consequences, mainly by exposing the patient to the risk of thromboses. We present a case where the diagnosis of PV was delayed due to the coexistence of HBT, and review the relevant literature. It can be postulated that "stress erythropoiesis", known to occur in patients with thalassemic syndromes, increases the probability of somatic JAK2 mutations leading to development of PV.

Premature mortality in the US: A convergence study.

Premature mortality is an important public health indicator with ramifications to social and economic outcomes. The purpose of this study is to examine whether premature mortality, measured by the years of potential life lost (YPLL), converges among the U.S. states and which mortality components lead to divergence. To this end, we calculate the YPLL and apply the Phillips and Sul (2007, 2009) convergence test methodology. We find that for males and blacks all U.S. states converge to a steady-state while for females, whites and total population, the states form convergence clubs. These clubs differ mainly due to variances in infant, cardiovascular and unintentional injury mortalities with the ones with the lesser YPLL located mainly on the west and east coast.

Solidification/stabilization of fly and bottom ash from medical waste incineration facility.

In the present work, the stabilization/solidification of fly and bottom ash generated from incinerated hospital waste was studied. The objectives of the solidification/stabilization treatment were therefore to reduce the leachability of the heavy metals present in these materials so as to permit their disposal in a sanitary landfill requiring only a lower degree of environmental protection. Another objective of the applied treatment was to increase the mechanical characteristics of the bottom ash using different amounts of Ordinary Portland Cement (OPC) as a binder. The solidified matrix showed that the cement is able to immobilize the heavy metals found in fly and bottom ash. The TCLP leachates of the untreated fly ash contain high concentrations of Zn (13.2 mg/l) and Pb (5.21 mg/l), and lesser amounts of Cr, Fe, Ni, Cu, Cd and Ba. Cement-based solidification exhibited a compressive strength of 0.55-16.12 MPa. The strength decreased as the percentage of cement loading was reduced; the compressive strength was 2.52-12.7 MPa for 60% cement mixed with 40% fly ash and 6.62-16.12 MPa for a mixture of 60% cement and 40% bottom ash. The compressive strength reduced to 0.55-1.30 MPa when 30% cement was mixed with 70% fly ash, and to 0.90-7.95 MPa when 30% cement was mixed with 70% bottom ash, respectively.

Mutation scanning of exon 20 of the BRCA1 gene by high-resolution melting curve analysis.

OBJECTIVES: 5382insC frameshift mutation along with 5331G>A (G1738R) missense mutation, both found in exon 20 of the BRCA1 gene, are relatively frequent among the Greek breast and ovarian cancer population (46%). Our goal was to develop a novel, reliable and rapid genotyping/scanning method for mutation detection of the exon 20 of the BRCA1 gene, using high-resolution melting curve analysis. DESIGN AND METHODS: The developed methodology was based on real-time PCR and high-resolution melting curve analysis in the presence of LCGreen I dye. Two amplicons on the exon 20 of BRCA1 gene were designed (157 bp and 100 bp), one flanking the exon's boundaries, and one embracing the 5382insC mutation. Our methodology was first optimized and validated by using genomic DNA samples with the 5382insC and 5331G>A (G1738R) mutations and wild-type. In total, the developed methodology was applied on 90 peripheral blood and 127 formalin-fixed paraffin-embedded breast tissue samples. RESULTS: Sensitivity studies with gDNA isolated from peripheral blood showed that mutated DNA could be reliably detected in the presence of wild-type DNA at 5% and 0.5% ratio with the larger and the smaller amplicon, respectively. By using the developed methodology we successfully identified 5382insC, 5331G>A and 5370C>T (R1751X) mutations, in genomic DNA isolated from peripheral blood samples and 5382insC mutation in two breast tumors, as verified by DNA sequencing. CONCLUSIONS: The combination of real-time PCR and high-resolution melting curve analysis provides a cost-efficient, simple and rapid approach to successfully scan exon 20 of BRCA1 gene for these clinically important and frequent mutations.