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Resistance to the polyether ionophore antibiotic pandavir (nigericin) in two producing strains of Streptomyces.

Moncheva, P A; Christova, K R; Ivanova, I V.

J Antibiot (Tokyo) ; 48(8): 811-4, 1995 Aug.

Article in English | MEDLINE | ID: mdl-7592025

ABSTRACT

In two pandavir (nigericin) producing strains, Streptomyces hygroscopicus 155 and Streptomyces albogriseolus 444, an enzyme activity was detected leading to inactivation of the antibiotic in the presence of ATP-Na2. Apparently, the observed inactivation is specific for the antibiotic produced by these strains. The nigericin producing strains were also found to be less permeable to pandavir than their non-producing variants.

Subject(s)

Anti-Bacterial Agents/metabolism , Nigericin/metabolism , Streptomyces/metabolism , Cell Wall/drug effects , Drug Resistance, Microbial/physiology , Ionophores/metabolism , Monensin/metabolism

Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene. XI: trans-6,9-dimethoxy-2,3,4a,5,10,10a-hexahydro-4H-naphth[2,3-b]1, 4-oxazines--tricyclic analogs trans-2-amino-3-hydroxy-5,8-dimethoxytetralins.

Troanska, G; Christova, K; Danchev, D.

Arch Pharm (Weinheim) ; 320(7): 625-9, 1987 Jul.

Article in English | MEDLINE | ID: mdl-2890334

Subject(s)

Naphthalenes/chemical synthesis , Oxazines/chemical synthesis , Psychotropic Drugs/chemical synthesis , Tetrahydronaphthalenes/chemical synthesis , Analgesics/chemical synthesis , Animals , Central Nervous System Stimulants/chemical synthesis , Chemical Phenomena , Chemistry , Oxazines/pharmacology , Sympathomimetics/chemical synthesis , Tetrahydronaphthalenes/pharmacology

Ether derivatives of 3-amino-1,2-propanediols, VI. Syntheses and pharmacological investigations of 5,8-bis-[2-hydroxy-3-(alkylamino)propoxy]-1,4-dihydronaphthalenes.

Chalina, E; Christova, K; Dantchev, D; Staneva, D; Rainova, L; Chakarova, L.

Arch Pharm (Weinheim) ; 320(7): 655-9, 1987 Jul.

Article in English | MEDLINE | ID: mdl-2890335

Subject(s)

Adrenergic beta-Antagonists/chemical synthesis , Antihypertensive Agents/chemical synthesis , Naphthalenes/chemical synthesis , Propylene Glycols/chemical synthesis , Adrenergic beta-Antagonists/toxicity , Animals , Antihypertensive Agents/toxicity , Electrocardiography , Lethal Dose 50 , Naphthalenes/toxicity , Propylene Glycols/toxicity , Rats , Rats, Inbred Strains , Spectrophotometry, Infrared

Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene, IX: Structure-activity relationships of cis- and trans-2-amino-5,8-dimethoxytetralin-3-ols and some analogues.

Christova, K; Dantchev, D; Staneva, D; Rainova, L.

Arch Pharm (Weinheim) ; 317(10): 829-34, 1984 Oct.

Article in English | MEDLINE | ID: mdl-6517670

Subject(s)

Anti-Arrhythmia Agents/chemical synthesis , Naphthalenes/chemical synthesis , Tetrahydronaphthalenes/chemical synthesis , Animals , Anti-Arrhythmia Agents/pharmacology , Blood Pressure/drug effects , Cats , In Vitro Techniques , Models, Molecular , Rabbits , Stereoisomerism , Structure-Activity Relationship , Tetrahydronaphthalenes/pharmacology

[Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene, VII: Aroyl esters of cis- and trans-2-dimethylamino-3-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalenes]. / Derivate des 2-Amino-1,2,3,4-tetrahydronaphthalins, 7. Mitt. Aroylester des cis- und trans-2-Dimethylamino-3-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalins.

Christova, K; Dantschev, D; Rainova, L; Staneva, D.

Arch Pharm (Weinheim) ; 315(9): 797-801, 1982 Sep.

Article in German | MEDLINE | ID: mdl-7138245

Subject(s)

Anesthetics, Local/chemical synthesis , Naphthalenes/chemical synthesis , Parasympatholytics/chemical synthesis , Tetrahydronaphthalenes/chemical synthesis , Animals , Guinea Pigs , In Vitro Techniques , Rabbits , Tetrahydronaphthalenes/pharmacology

[Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene, III: Synthesis of some N'-substituted N-(trans-3-hydroxy-1,2,3,4-tetrahydro-2-naphthyl)piperazines (author's transl)]. / Derivate des 2-Amino-1,2,3,4-tetrahydronaphthalins, III. Synthese einiger N'-substituierter N-(trans-3-Hydroxy-1,2,3,4-tetrahydro-2-naphthyl)-piperazine.

Ivanov, I C; Troanska, G R; Christova, K S; Dantchev, D K; Sulay, P B; Waltchanova, R P.

Arch Pharm (Weinheim) ; 310(11): 925-31, 1977 Nov.

Article in German | MEDLINE | ID: mdl-931581

Subject(s)

Piperazines/chemical synthesis , Anti-Arrhythmia Agents/chemical synthesis , Antihypertensive Agents/chemical synthesis

[Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene, II: Synthesis and pharmacological investigation of N-substituted trans-2-amino-3-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalenes (author's transl)]. / Derivate des 2-Amino-1,2,3,4-Tetrahydronaphthalins, II. Synthese und pharmakologische Untersuchung von N-substituierten trans-2-Amino-3-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalinen

Dantchev, D; Christova, K; Staneva, D; Rainova, L; Tschakarova, L.

Arch Pharm (Weinheim) ; 310(5): 369-79, 1977 May.

Article in German | MEDLINE | ID: mdl-869687

Subject(s)

2-Naphthylamine/chemical synthesis , Naphthalenes/chemical synthesis , 2-Naphthylamine/analogs & derivatives , 2-Naphthylamine/pharmacology , Animals , Blood Pressure/drug effects , Cats , Central Nervous System/drug effects , Depression, Chemical , Guinea Pigs , Muscle, Smooth/drug effects , Rabbits , Respiration/drug effects

[Acylation of n,n'-polymethylene carbamide (author's transl)]. / Uber die Acylierung von N,N'-Polymethylengarnstoffen

Dantchev, D; Christova, K; Mutaftschieva, V; Daleva, D.

Arch Pharm (Weinheim) ; 307(9): 673-81, 1974 Sep.

Article in German | MEDLINE | ID: mdl-4421727

Subject(s)

Urea/analogs & derivatives , Acylation , Carbamates , Chemical Phenomena , Chemistry , Cyclization , Polymers

[1-Azgomethine derivatives from 3.3-diethyl-5-methyl-2.4-piperidinedione]. / 1-Azomethinderivate des 3.3-Diäthyl-5-methyl-2.4-piperidindions.

Dantschev, D; Daleva, L; Christova, K; Mutaftschieva, V.

Pharmazie ; 27(10): 636-8, 1972 Oct.

Article in German | MEDLINE | ID: mdl-4404615

Subject(s)

Hydrazines/chemical synthesis , Piperidines/chemical synthesis , Piperidones , Central Nervous System/drug effects , Chemical Phenomena , Chemistry , Hydrazones/analysis , Hydrazones/chemical synthesis , Hydrazones/pharmacology , Lethal Dose 50 , Piperidines/analysis , Spectrophotometry, Infrared

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