ABSTRACT
Certain haemostatic parameters were determined in workers engaged in disinfection, disinsection and deratization. Patients have been divided into subgroups according to length of employment and range of performed d.d.d. activities. In addition, the effect of acute HCN exposure during fumigation was evaluated. The results may evidence partial liver disfunction in most examined patients.
Subject(s)
Air Pollutants, Occupational/toxicity , Blood Coagulation/drug effects , Chloramines/toxicity , Fibrinolysis/drug effects , Hydrogen Cyanide/toxicity , Adolescent , Adult , Aged , Animals , Blood Coagulation Tests , Disinfectants , Female , Fibrinogen/analysis , Humans , Male , Middle Aged , Pest Control , Pesticides , Plasminogen/analysis , RatsABSTRACT
Serous activity of AspAT, A1AT, LDH, GLDH, AP, ChE was checked, and BSP retention and protein level as well as its electrophoretic division were determined in 42 DDD Plant workers. The subject group was divided into subgroups depending on the degree of exposure to various chemicals and length of occupational exposure. In a considerable percentage of subjects, changes in serous activity of the enzymes concerned and defective BSP retention were found. The biochemical parameters were analysed and a possibility was enhanced of the occurrence of subacute poisonings changing into chronic ones, including liver parenchyma lesion.
Subject(s)
Blood Proteins/analysis , Disinfection , Enzymes/blood , Insect Control , Occupational Medicine , Rodent Control , Sterilization , Sulfobromophthalein , Adolescent , Adult , Aged , Alanine Transaminase/blood , Alkaline Phosphatase/blood , Animals , Aspartate Aminotransferases/blood , Cholinesterases/blood , Female , Glutamate Dehydrogenase/blood , Humans , L-Lactate Dehydrogenase/blood , Male , Middle Aged , RatsABSTRACT
The observed group included 91 children aged from 2 to 15 years divided into two groups: I control--25 children, and II--66 children with severe infantile cerebral palsy. The following biochemical investigations were done in the cerebrospinal fluid: total LDH activity and total protein level before and after fluid condensation, and determination of LDH isoenzymes after condensation of fluid. In the group of children with absence of organic lesions of the central nervous system the mean total LDH activity was 17.6 mU/ml, this value was similar to that found by most authors. The isoenzyme pattern in the control group contained 3--4 fractions, the LDH4 fraction was, however, found in 2 cases only. In the group with infantile cerebral palsy the total LDH activity in the cerebrospinal fluid showed a considerable range of variations, its mean value was 32.7 mU/ml and was highly significantly above the mean value in controls. The LDH isoenzyme pattern in this group consisted of 4--5 LDH fractions with a fairly high proportion of cases with LDH4 and LDH5 fractions and with a high absolute activity of these fractions.