ABSTRACT
Increased frequency of cells with chromosomal aberrations was revealed in 48-h cultures of peripheral blood lymphocytes isolated North Ossetia residents with impaired reproductive function. After 2-week treatment with antimutagenic drug Afobazole, the percentage of cells with chromosomal aberrations significantly decreased from 3.77±0.20 to 2.48±0.24% (p<0.001). Significant differences between chromosome damage levels before and after administration of the drug suggest that Afobazole could be recommended for protective purposes to this group of patients.
Subject(s)
Antimutagenic Agents/therapeutic use , Benzimidazoles/therapeutic use , Chromosome Aberrations , Environmental Exposure/adverse effects , Infertility, Female/drug therapy , Infertility, Male/drug therapy , Morpholines/therapeutic use , Adult , Case-Control Studies , Cytogenetic Analysis , Drug Administration Schedule , Female , Humans , Infertility, Female/etiology , Infertility, Female/genetics , Infertility, Female/pathology , Infertility, Male/etiology , Infertility, Male/genetics , Infertility, Male/pathology , Leukocytes, Mononuclear/metabolism , Leukocytes, Mononuclear/pathology , Male , Metaphase , Mutagenesis , Treatment OutcomeABSTRACT
The mean count of cells with chromosome aberrations increased in a 72-h culture of peripheral blood lymphocytes of children with Helicobacter pylori-associated gastroduodenal diseases. After eradication therapy, intensification of clastogenesis was observed in the majority of children. Addition of vetoron to the treatment protocols reduced manifestations of clastogenesis.
