Protective Restraint Nursing Interventions in ICU Patients: Assessing their Influence on Unplanned Extubation and Skin Injury Incidence.

Objective: This study aims to investigate the application of protective restraint nursing interventions in intensive care unit (ICU) patients and their impact on the incidence of unplanned extubation and skin damage. Methods: A total of 90 ICU patients admitted to Hai'an People's Hospital between January 2019 and December 2020 were randomly assigned to either the experimental group or the control group in a 1:1 ratio. The control group received conventional nursing care, while the experimental group received protective restraint nursing interventions. The Hospital Anxiety and Depression (HAD) scale, a clinical tool used to assess patients' levels of anxiety and depression, was employed to evaluate patients' emotional states before and after the intervention. A Patient Clinical Satisfaction Survey Questionnaire developed by our department was used to assess patient satisfaction after nursing. Compliance and the incidence of adverse reactions were compared between the two groups. Results: The experimental group exhibited significantly lower HADS scores, higher nursing satisfaction, and a lower incidence of unplanned extubation, skin damage, and adverse reactions compared to the control group (all P < .05). Conclusions: Protective restraint care demonstrates substantial benefits for ICU patients by reducing the incidence of unplanned extubation, preventing skin damage during treatment, improving compliance, and facilitating recovery. These findings support the clinical application and promotion of protective restraint nursing interventions.

D-A Structural Oligomers Containing Benzothiadiazole or Benzophenone as Novel Multifunctional Materials for Electrochromic and Photodetector Devices.

In this study, six conjugated oligomers containing D-A structures were synthesized using the Stille coupling reaction and named PHZ1-PHZ6. All the oligomers utilized demonstrated excellent solubilities in common solvents and notable color variations in the domain of electrochromic characteristics. By designing and synthesizing two electron-donating groups modified with alkyl side chains and a common aromatic electron-donating group, as well as cross-binding them with two electron-withdrawing groups with lower molecular weights, the six oligomers presented good color-rendering efficiencies, among which PHZ4 presented the best color-rendering efficiency (283 cm2·C-1). The products also demonstrated excellent electrochemical switching-response times. PHZ5 presented the fastest coloring time (0.7 s), PHZ3 and PHZ6 presented the fastest bleaching times (2.1 s). Following 400 s of cycling activity, all the oligomers under study showed good working stabilities. Moreover, three kinds of photodetectors based on conducting oligomers were prepared, and the experimental results show that the three photodetectors have better specific detection performances and gains. These characteristics indicate that oligomers containing D-A structures are suitable for use as electrochromic and photodetector materials in the research.

Clinical Promotion of Comfort Nursing Combined with Comprehensive Nursing in the Treatment of Severe Stroke Patients with Diabetes in ICU.

Objective: To investigate the application value of comprehensive nursing combined with comfort nursing for severe stroke patients with diabetes in the intensive care unit (ICU), as well as its effect on the incidence of pressure ulcers and aspiration. Methods: Between March 2019 and March 2021, 123 severe stroke patients with diabetes who were treated at our hospital were randomly assigned to one of two groups: the control group (n = 61) or the study group (n = 62). The control group received normal care, but the research group received comprehensive nursing as well as comfort nursing. The two patient groups were compared in terms of the effects of the clinical application. Results: The two groups did not differ significantly in general data (P > 0.05). The shorter ICU monitoring and extubation times, the lower incidence of pressure ulcers, aspiration, and nosocomial infections, and higher self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores and a lower MOS 36-item short-form health survey (SF-36) score were all observed in the research group when compared to the control group (P < 0.05). Conclusion: For severe stroke patients with diabetes in the ICU, comprehensive nursing combined with comfort nursing has a promising effect, significantly, lowering the risk of pressure ulcers, aspiration, and nosocomial infections, accelerating physical recovery, enhancing mental state, and ensuring a better prognosis, deserving general clinical promotion.

Diagnostic Accuracy of Deep Learning and Radiomics in Lung Cancer Staging: A Systematic Review and Meta-Analysis.

Background: Artificial intelligence has far surpassed previous related technologies in image recognition and is increasingly used in medical image analysis. We aimed to explore the diagnostic accuracy of the models based on deep learning or radiomics for lung cancer staging. Methods: Studies were systematically reviewed using literature searches from PubMed, EMBASE, Web of Science, and Wanfang Database, according to PRISMA guidelines. Studies about the diagnostic accuracy of radiomics and deep learning, including the identifications of lung cancer, tumor types, malignant lung nodules and lymph node metastase, were included. After identifying the articles, the methodological quality was assessed using the QUADAS-2 checklist. We extracted the characteristic of each study; the sensitivity, specificity, and AUROC for lung cancer diagnosis were summarized for subgroup analysis. Results: The systematic review identified 19 eligible studies, of which 14 used radiomics models and 5 used deep learning models. The pooled AUROC of 7 studies to determine whether patients had lung cancer was 0.83 (95% CI 0.78-0.88). The pooled AUROC of 9 studies to determine whether patients had NSCLC was 0.78 (95% CI 0.73-0.83). The pooled AUROC of the 6 studies that determined patients had malignant lung nodules was 0.79 (95% CI 0.77-0.82). The pooled AUROC of the other 6 studies that determined whether patients had lymph node metastases was 0.74 (95% CI 0.66-0.82). Conclusion: The models based on deep learning or radiomics have the potential to improve diagnostic accuracy for lung cancer staging. Systematic Review Registration: https://inplasy.com/inplasy-2022-3-0167/, identifier: INPLASY202230167.

The effects of video based nursing education on perioperative anxiety and depression in patients with gastric cancer.

The purpose of this study was to determine the effect of video-based nursing education on perioperative anxiety and depression. A total of 128 patients scheduled for minimally invasive gastrectomy were randomly divided into intervention (n = 64) and control (n = 64) group. The. The anxiety and depression scores, systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were assessed before the intervention, 1 h before surgery and 24 h after surgery. And the cortisol levels were measured before the intervention and 1 h before surgery. No significant difference was observed in baseline anxiety score, depression score, vital signs and cortisol level (P > 0.05). The anxiety level, depression level, SBP, DBP and HR of patients in intervention group was significantly lower than that in control group at 1 h before surgery and 24 hs after surgery (P < 0.05). The serum cortisol in the intervention group was also significantly lower than that in the control group 1 h before surgery (p < 0.001). Video-based nursing education was effective in decreasing the perioperative anxiety and depression of patients undergoing minimally invasive gastrectomy. It could also keep vital signs and serum cortisol levels in normal limits.

Influence of self-management exercise intervention on the cancer related fatigue severity and self-management efficacy of patients with non-small cell lung cancer after operation.

OBJECTIVE: To investigate the influence of self-management exercise intervention on postoperative cancer-related fatigue severity and self-management efficacy of patients with non-small cell lung cancer. METHODS: Seventy patients with non-small cell lung cancer were selected in Pidu district people's hospital from January 2018 to January 2019 and randomised into 2 groups with the random number table, including control group (35 cases) and experimental group (35 cases). The control group received conventional intervention, while the experimental group was intervened by self-management exercise based on the conventional intervention. The baseline clinical characteristics, simple fatigue scale scores, self-efficacy indicators, and physical and mental health scores of 2 groups were compared. RESULTS: The simple fatigue scale score of both groups were measured six weeks after surgery. The experimental group was significantly lower than that of control group (P<0.05). The self-efficacy scores of continuous walking for 30 minutes six weeks after the operation in both groups continuously increased with time and the result of the experimental group was significantly higher than that of control group (P<0.05). Similarly the postoperative balance ability self-efficacy scores of both groups were on the rise with time but the score of experimental group was significantly higher than that of control group after 6 weeks of surgical treatment (P<0.05). The postoperative health scores of both groups improved with time and the physical and mental health scores of experimental group were significantly higher than those of control group after 6 weeks of surgical treatment (P<0.05). CONCLUSIONS: Self-management exercise intervention can effectively alleviate postoperative cancer-related fatigue of patients with non-small cell lung cancer, enhance self-management efficiency and contribute to improving the status of body functions.

Purification and characterization of aporphine alkaloids from leaves of Nelumbo nucifera Gaertn and their effects on glucose consumption in 3T3-L1 adipocytes.

Aporphine alkaloids from the leaves of Nelumbo nucifera Gaertn are substances of great interest because of their important pharmacological activities, particularly anti-diabetic, anti-obesity, anti-hyperlipidemic, anti-oxidant, and anti-HIV's activities. In order to produce large amounts of pure alkaloid for research purposes, a novel method using high-speed counter-current chromatography (HSCCC) was developed. Without any initial cleanup steps, four main aporphine alkaloids, including 2-hydroxy-1-methoxyaporphine, pronuciferine, nuciferine and roemerine were successfully purified from the crude extract by HSCCC in one step. The separation was performed with a simple two-phase solvent system composed of n-hexane-ethyl acetate-methanol-acetonitrile-water (5:3:3:2.5:5, v/v/v/v/v). In each operation, 100 mg crude extracts was separated and yielded 6.3 mg of 2-hydroxy-1-methoxyaporphine (95.1% purity), 1.1 mg of pronuciferine (96.8% purity), 8.5 mg of nuciferine (98.9% purity), and 2.7 mg of roemerine (97.4%) respectively. The chemical structure of four aporphine alkaloids are identified by means of electrospray ionization MS (ESI-MS) and nuclear magnetic resonance (NMR) analysis. Moreover, the effects of four separated aporphine alkaloids on insulin-stimulated glucose consumption were examined in 3T3-L1 adipocytes. The results showed that 2-hydroxy-1-methoxyaporphine and pronuciferine increased the glucose consumption significantly as rosiglitazone did.