A comprehensive assessment of environmental factors in aircraft cockpit based on fuzzy evaluation.

BACKGROUND: The cockpit of an aircraft is the main place where the pilot controls the aircraft on a mission. An excellent cockpit environment not only ensures the pilot's basic survival needs but also improves the comfort level and alleviates fatigue when performing missions. OBJECTIVE: On the basis of domestic and international airworthiness standards, a top-down refinement method is deployed to determine the initial goal, and the environmental criteria are fully discussed and balanced in a dynamic process to build a comprehensive evaluation system for environmental factors in the aircraft cockpit. METHODS: Based on the fuzzy comprehensive evaluation theory, an evaluation model for environmental factors is constructed by combining analytic hierarchical analysis (AHP) and particle swarm optimization (PSO). Then the feasibility of the evaluation model is verified by an illustrative example. RESULTS: The results suggest that the light environment gains the highest score among the 4 environmental criteria followed by the thermal environment, while both sound environment and microenvironment have relatively low scores. CONCLUSION: As for the 27 environmental sub-criteria, temperature, illumination, lighting clarity, light-color coordination, noise duration and pressure score the highest. The evaluation findings can provide important environmental control criteria for the subsequent environmental control system in the cockpit of the aircraft.

A Vehicle Simulation Study Examining the Effects of System Interface Design Elements on Performance in Different Vibration Environments Below 3 Hz.

OBJECTIVE: This study aimed to explore the relationship between system interface elements' design features and interaction performance in simulated vehicle vibration environments. BACKGROUND: Touch screens have been widely used in vehicle information systems, but few studies have focused on the decline of touchscreen interaction performance and task load increase when driving on unpaved roads. METHOD: The interaction performance (reaction time and task accuracy rate) with vibration frequencies below 3 Hz (1.5, 2.0, and 2.5 Hz) and different interface design elements was investigated employing a touch screen computer and E-prime software. RESULTS: The results indicate that vehicle vibration (below 3 Hz) can significantly reduce interaction performance with a vehicle information system interface. CONCLUSION: An appropriate increase in the physical size of the interface design features (visual stimulus materials and touch buttons) can help to mitigate this negative effect of vibration. APPLICATION: The results and findings of this study can be utilized for the design of information system interfaces as it relates to the vibration scenario of unpaved roads.

Effects of aircraft tray table height and neck posture on passenger comfort: A study of the economy class cabin.

BACKGROUND: The tray table in economy class air travel may cause excessive neck flexion and discomfort in passengers. OBJECTIVE: The purpose of this study is to examine the influence of different tray table heights on the neck posture and discomfort perception of passengers. METHODS: A passenger experience survey was used to determine the passengers' view that the tray table was not high enough, and that most passengers were dissatisfied with the overall comfort evaluation of the tray table, especially passengers with obesity. Three head-neck angles and discomfort perceptions of six body parts in 58 participants were recorded by neck posture 3D scanning and perceived level of discomfort assessment, respectively. RESULTS: Tray tables at the original height (68 cm) caused unnatural neck posture and discomfort in participants. Raising the tray table can improve the neck posture of participants and reduce discomfort. However, raising the tray table too high will cause more shoulder discomfort in participants. Based on the results, 78 (±2) cm is suggested as the suitable thresholds range of tray tables for economy class air travel. CONCLUSION: The results and findings of this study could provide a theoretical base for the optimization of tray table design.

Analysis of the auricles and auricular shape types for ear-related wearables: A study of mainland Chinese sample aged 15-79.

BACKGROUND: Comprehension of the complex shape of the auricle and how it differs in terms of factors such as sex, age, and side have become an imperative aspect of the fabrication and service delivery of products that are natural, functional, and healthy for users. OBJECTIVE: This study was aimed at providing a clear understanding of the anthropometric characteristics based on age, sex, size, and side and shape type of the auricles of mainland Chinese samples. METHODS: Casting and 3D scanning were employed to obtain eighteen auricular measurement variables from 1120 subjects (aged 15-79). Examination of sex-related and bilateral differences were conducted. Furthermore, factor analysis was employed to establish the factors associated with the variations in auricular shape. Also, hierarchical cluster analysis was performed to classify the auricular shapes of individuals. RESULTS: The auricular inclination angle, conchal depth and tragal height did not exhibit any specific trend across the age groups. No significant bilateral difference was observed in both genders. The auricular shapes were classified into five types according to six major factors. CONCLUSIONS: It was observed that measurement variables of the Chinese auricles changed continuously with age, with most of the linear variables exhibiting a steady increase. The apparent strong association between the auricular types and age groups indicate that a person's auricular shape may change with age.

Effects of variations in the tragus expansion angle on physical comfort for in-ear wearables.

Tragus expansion angle (TEA) is an angular variable that quantifies the outward degree of expansion of the tragus cartilage induced by in-ear wearables (designed with hard materials) fitted into the external ear. It is a physical factor that directly influence user's comfort experience during interaction with in-ear wearables. This study was aimed at quantifying the effects of variations in TEA on physical comfort. TEA was measured and normalised employing a measuring device and Tragus Expansion Index (TEI) proposed in this study. Physical (dis)comfort was assessed using a rating scale designed based on the 5-point Likert and Borg-CR10 scales. Comparatively, the comfort range of variations in TEA was similar for both genders. Males could endure a higher level of variations in TEA compared to females. A quantitative relationship between variations in TEA and (dis)comfort ratings was established using TEI values and GaussAmp function, which can be employed for ergonomic design purposes. Practitioner summary: This study provides an empirical and available source for quantifying the effects of variations in the tragus expansion angle on physical comfort, including quantitative tools and (dis)comfort rating models, which could be used as a reference for improving the fit, comfort and functional capacity of in-ear wearable devices.

Effect of airplane passenger seat armrest height on human neck comfort when using a smartphone.

OBJECTIVES: The objective of this study was to explore the relationship between seat armrest height and human neck comfort when using a smartphone while sitting on a passenger seat during the flight. MATERIAL AND METHODS: The authors used a wireless angle-measuring instrument and subjective comfort scale to evaluate the changes of head flexion angle and neck comfort level of 24 young smartphone users in an aircraft simulated cabin. RESULTS: The study results indicated that using a smartphone while sitting on a passenger seat during the flight would pose a larger discomfort to the neck, and the discomfort would be higher for gaming than reading tasks. Seat armrest height is related to the comfort level of the neck when using a smartphone, increasing the height of the armrest can effectively alleviate discomfort in this state. CONCLUSIONS: Considering the prevalence of passengers using smartphones in aircraft, a seat armrest that can be properly adjusted in height, which can effectively reduce the risk of passenger head flexion angle and neck discomfort. Int J Occup Med Environ Health. 2022;35(2):199-208.

A Consensus-Reaching Approach to the Evaluation of Product Design Alternatives with Multiple Preference Structures.

With interdisciplinarity being an important characteristic of contemporary product design, the evaluation of design alternatives also involves multiple disciplines, and the evaluator group usually consists of evaluators from different fields and with obvious heterogeneous characteristics. To effectively satisfy the heterogeneous needs of evaluators and improve the credibility of evaluation results, the paper introduces a consensus-reaching approach that incorporates multiple preferences to the evaluation of product design alternatives. First, in order to obtain individual preference information, each evaluator is asked to evaluate all the design alternatives using a preference structure that he/she is familiar with. Second, we use a transfer function to uniform the evaluation information obtained from various preference structures into a complementary judgment matrix. Then, we use the Hybrid Weighted Averaging (HWA) operator weight determination model to aggregate the preference information and obtain the group preference information. Then, we measure the consensus degree between individual evaluators and the group using a consensus measurement method. After that, we use the feedback mechanism to instruct individual evaluators to modify their preferences until a consensus is achieved. We explain the application steps and the feasibility of this approach through the evaluation of the design alternatives of multichannel fluorescence immunochromatography analyzers (MFIAs).

Analysis of the external acoustic meatus for ergonomic design: part I - measurement of the external acoustic meatus using casting, scanning and rapid estimation approaches.

Numerous ear-related wearables require precise measurements of the external acoustic meatus (EAM) to optimise function and comfort. The purpose of this study is to describe a novel methodology for measuring the EAM. A total of 23 measurement variables (18 novel) of the EAM from the entrance to the second bend were collected on 700 Chinese subjects (age: 15-83) using casting and 3D scanning over seven age spans: 10, 20, 30, 40, 50, 60 s and 70+. The ear horizontal plane was identified as a new reference plane for measurements and the medial concha was selected as the reference point for positioning the entrance. A detailed approach to characterising the EAM was developed as was an approach for the rapid estimation of circumference and area using regression equations making it ideal for use in early design conceptualizations. Practitioner summary: This study provides a scalable measurement methodology for determining anthropometric measurements of the external acoustic meatus. The measurement methodology and its application to the design and fitting of ear-related wearables are important to optimising their function and comfort.

The effects of the seat cushion contour and the sitting posture on surface pressure distribution and comfort during seated work.

OBJECTIVES: The purpose of this paper is to investigate the effects of the seat cushion contour and the sitting posture on the seat pan interface pressure distribution and subjective comfort perception. MATERIAL AND METHODS: Overall, 16 volunteers typed a text passage on a laptop while seated, by assuming 3 kinds of common sitting postures (forward, relaxed and upright) in 4 seat cushion configurations: chair only, and chair with 1 of 3 supplementary cushions. Pressure data and cushion comfort ratings were collected in the experiment. RESULTS: It was found that the sitting posture and the seat cushion contour had different impacts on surface pressure. The seat cushion contour had an impact on pressure parameters and pressure distribution on the seat pan, while the sitting posture affected the location of peak pressure on the seat pan. The correlation analysis revealed that the subjective comfort rating was significantly correlated with average pressure (AP) and mean peak pressure (MPP). CONCLUSIONS: The conclusion was that the cushion contour had a greater effect on seat pan interface pressure parameters than the sitting posture. Notably, AP and MPP can be indicators for assessing seat cushion comfort in a short-term perspective. Int J Occup Med Environ Health. 2020;33(5):675-89.

Chikusetsu saponin IVa protects pancreatic ß cell against intermittent high glucose-induced injury by activating Wnt/ß-catenin/TCF7L2 pathway.

Islet ß cell mass reduction induced by glucose fluctuation is crucial for the development and progression of T2DM. Chikusetsu saponin IVa (CHS) had protective effects against DM and related injuries. Here we aimed to investigate the role of CHS in ß cell injuries and its possible mechanism involved. Isolated rat islets, ßTC3 cells and T2DM mice were used in this study. The results showed that CHS restored the secretion activity, promoted ß cell survival by increasing ß cell proliferation and decreasing apoptosis which induced by intermittent high glucose (IHG). In vivo, CHS protected ß cell apoptosis to normalize blood glucose and improve insulin sensitivity in DM mice. Further studies showed that CHS activated Wnt3a signaling, inhibited HBP1, promoted ß-catenin nuclear translocation, enhanced expressions of TCF7L2, GIPR and GLP-1R, inhibited p53, p27 and p21. The protective effect of CHS was remarkably suppressed by siRNAs against TCF7L2 or XAV-939 (a Wnt/ß-catenin antagonist) in vitro and in ß-catenin-/- mice. In conclusion, we identified a novel role of CHS in protecting ß cell survival and regeneration by mechanisms involving the activation of Wnt3a/ß-catenin/TCF7L2 signaling. Our results indicated the potential value of CHS as a possible intervention drug for T2DM.

Shoulder girdle muscle activity and fatigue during automobile chassis repair

Objectives: The objective of this study was to assess the postures that were commonly used in automobile chassis repair operations, and to evaluate shoulder girdle muscle fatigue for different combinations of the weight of hand-tools. Material and Methods: Two right muscles, including upper trapezius (UT) and middle deltoid (MD), were selected. Surface electromyography (SEMG) and a perceived level of discomfort (PLD) were used to assess the degree of shoulder girdle fatigue. Fifteen healthy young male subjects from the Northwestern Polytechnical University participated in the test. The test consisted of assuming 4 different postures and maintaining each of them for 60 s. The 4 postures varied in terms of dumbbell weights, standing for the hand-tools weight: W1 was 0.48 kg and W2 was 0.75 kg; the 4 shoulder postures were shoulder flexions of 150°, 120°, 90°, and 60°, combined with an included elbow angle of 180°, 150°, 120° and 90°, respectively. The experimental sequences were randomly selected. The signals of SEMG and the values of PLD in the shoulder girdle were recorded in 60 s. All subjects completed the whole test. The repeated measure analysis of variance (ANOVA) was performed to ascertain differences between dumbbell weight (0.48 kg and 0.75 kg) and shoulder postures (150°/180°, 120°/150°, 90°/120° and 60°/90°). The Friedman test was utilized to determine the significant differences for UT(PLD) and MD(PLD) on shoulder postures. Spearman's correlation was used to analyze the relationship between the subjective and objective measurements. Results: Significant correlational relationships existed between the UT percentage of the maximal voluntary electrical activation (%MVE) and UT(PLD) (r = 0.459, p < 0.01), between MD(%MVE) and MD(PLD) (r = 0.821, p < 0.01). The results showed that SEMG and PLD of the 4 postures under analysis differed significantly (p < 0.05). Conclusions: It was indicated that posture T4 (shoulder forward flexion 60° and included elbow angle 90°) resulted in the lowest fatigue, both in terms of the objective measure and the subjective perception, which meant that this posture was more ergonomic. Int J Occup Med Environ Health. 2019;32(4):537­52

Design and synthesis of novel 1-phenyl-3-(5-(pyrimidin-4-ylthio)-1,3,4-thiadiazol- 2-yl)urea derivatives with potent anti-CML activity throughout PI3K/AKT signaling pathway.

In this investigation, a series of 1-phenyl-3-(5-(pyrimidin-4-ylthio)-1,3,4- thiadiazol-2-yl)urea receptor tyrosine kinase inhibitors were synthesized by a simple and efficient structure-based design. Structure-activity relationship (SAR) analysis of these compounds based on cellular assays led to the discovery of a number of compounds that showed potent activity against human chronic myeloid leukemia (CML) cell line K562, but very weak or no cellular toxicity through monitoring the growth kinetics of K562 cell during a period of 72 h using the real-time live-cell imaging. Among these compounds, 1-(5-((6-((3-morpholinopropyl) amino)pyrimidin-4-yl)thio)-1,3,4-thiadiazol-2-yl)-3-(4-(trifluoromethyl)phenyl)urea (7) exhibited the least cellular toxicity and better biological activity in cellular assays (K562, IC50: 0.038 µM). Compound 7 also displayed very good induced-apoptosis effect for human CML cell line K562 and exerted its effect via a significantly reduced protein phosphorylation of PI3K/Akt signal pathway by Human phospho-kinase array analysis. In vitro results indicate that 1-phenyl-3-(5-(pyrimidin-4-ylthio)-1,3,4- thiadiazol-2-yl)urea derivatives are lead molecules for further development as treatment of chronic myeloid leukemia and cancer.

Quantification of lower extremity physical exposures in various combinations of sit/stand time duration associated with sit-stand workstation.

BACKGROUND: Sit-stand workstations are available for office work purposes but there is a dearth of quantitative evidence to state benefits for lower limb outcomes while using them. And there are no guidelines on what constitutes appropriate sit/stand time duration. The primary aim of this study has been to compare muscle activity and perceived discomfort in the lower extremity during various combinations of sit/stand time duration associated with a sit-stand workstation separately and to evaluate the effects of the sit-stand workstation on the lower extremity during the text entry task. MATERIAL AND METHODS: During the 5 days, all participants completed a 2-h text entry task each day for various sit/stand time duration combinations as follows: 5/25 min, 10/20 min, 15/15 min, 20/10 min, 25/5 min. Lower extremity muscular exposure of 12 male and 13 female participants was collected at 8 sites by surface electromyography and body discomfort was calculated by a questionnaire under those 5 conditions. RESULTS: Results have demonstrated that lower extremity muscle activity has been significantly varied among the 5 sit/stand time duration groups. Perceived level of discomfort (PLD) has not differed significantly for 9 out of 10 body parts. CONCLUSIONS: The muscle activity of the thigh region was influenced by sit/stand time duration significantly. Ergonomic exposures of lower extremity when using a sit-stand workstation were increased, particularly during the long time standing posture. Results indicate that body mass index (BMI) and gender were not significant factors in this study. Combination of sit/stand time duration 25/5 min appears to show positive effects on relief of muscle exposure of back of thigh in the shifts of sitting and standing work position. Med Pr 2017;68(3):315-327.

Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-ß1-Induced Epithelial-to-Mesenchymal Transition.

OBJECTIVE: Renal fibrosis is the common pathological foundation of many chronic kidney diseases (CKDs). The aim of this study was to investigate whether Hydroxysafflor yellow A (HSYA) can preserve renal function by inhibiting the progression of renal fibrosis and the potential mechanisms. METHODS: Renal fibrosis was induced by unilateral ureteral obstruction (UUO) performed on 7-week-old C57BL/6 mice. HSYA (10, 50 and 100 mg/kg) were intragastrically administered. Sham group and model group were administered with the same volume of vehicle. Serum and kidney samples were collected 14 days after the UUO surgery. Serum biochemical indicators were measured by automatic biochemical analyzer. Histological changes were evaluated by HE and Masson staining. In vitro, the anti-fibrotic effect of HSYA was tested on human recombinant transforming growth factor-ß1 (TGF-ß1) stimulated HK-2 cells. The protein levels of α-SMA, collagen-I and fibronectin in kidney tissue and HK-2 cells were measured by immunohistochemistry and immunofluorescence. The protein levels of apoptosis-relative and TGF-ß1/Smad3 signaling were detected by western blot. RESULTS: HSYA slowed the development of renal fibrosis both in vivo and in vitro. In UUO rats, renal function index suggested that HSYA treatment decreased the level of serum creatinine (Scr) and blood urea nitrogen (BUN) rose by UUO (P<0.05). HE staining and Masson staining demonstrated that kidney interstitial fibrosis, tubular atrophy, and inflammatory cell infiltration were notably attenuated in the high-dose HSYA group compared with the model group. The expressions of α-SMA, collagen-I and fibronectin were decreased in the UUO kidney and HK-2 cells of the HSYA-treatment group. Moreover, HSYA reduced the apoptotic rate of HK-2 cells stimulated by TGF-ß1. Further study revealed that HSYA regulated the TGF-ß1/Smads signaling pathway both in kidney tissue and HK-2 cells. CONCLUSIONS: These results suggested that HSYA had a protective effect against fibrosis in renal cells, at least partly, through inhibiting TGF-ß1/smad3-mediated Epithelial-mesenchymal transition signaling pathway.