Exploring the impact of hydrogen sulfide on hematologic malignancies: A review.

Hydrogen sulfide (H2S) is one of the three most crucial gaseous messengers in the body. The discovery of H2S donors, coupled with its endogenous synthesis capability, has sparked hope for the treatment of hematologic malignancies. In the last decade, the investigation into the impact of H2S has expanded, particularly within the fields of cardiovascular function, inflammation, infection, and neuromodulation. Hematologic malignancies refer to a diverse group of cancers originating from abnormal proliferation and differentiation of blood-forming cells, including leukemia, lymphoma, and myeloma. In this review, we delve deeply into the complex interrelation between H2S and hematologic malignancies. In addition, we comprehensively elucidate the intricate molecular mechanisms by which both H2S and its donors intricately modulate the progression of tumor growth. Furthermore, we systematically examine their impact on pivotal aspects, encompassing the proliferation, invasion, and migration capacities of hematologic malignancies. Therefore, this review may contribute novel insights to our understanding of the prospective therapeutic significance of H2S and its donors within the realm of hematologic malignancies.

A study of preparing silver iodide nanocolloid by electrical spark discharge method and its properties.

This study employed an electric discharge machine (EDM) and the Electrical Spark Discharge Method (ESDM) to prepare silver iodide nanocolloid (AgINC). Povidone-iodine (PVP-I) was dissolved in deionized water to create a dielectric fluid. Silver material was melted using the high temperature generated by an electric arc, and the peeled-off material was reacted with PVP-I to form AgI nanoparticles (AgINPs). Six discharge pulse wave parameter combinations (Ton-Toff) were employed, and the resultant particle size and suspension of the prepared samples were examined. The results revealed that AgINPs were successfully created using the ESDM. When Ton-Toff was set at 90-90 µs, the zeta potential of the AgINC was - 50.3 mV, indicating excellent suspension stability. The AgINC particle size was 16 nm, verifying that the parameters yielded AgINPs with the smallest particle size distribution and highest zeta potential. Ultraviolet-visible spectrum analyser was performed to analyse the samples, and the spectra indicated that the characteristic wavelength was 420 nm regardless of the Ton-Toff values. X-ray diffraction analysis determined that the AgINPs exhibited two crystal structures, namely ß-AgI and Ag. Transmission electron microscopy was performed and revealed that the particles were irregularly shaped and that some of the larger particles had aggregated. The crystal structure was determined to be a mixture of Ag and ß-AgI, with a lattice spacing of 0.235 nm and 0.229 nm, respectively. The lattice spacing of the Ag was 0.235 nm. X-ray diffraction analysis indicated that the prepared AgINC were composed of only Ag and I; no additional chemical elements were detected.