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Part 1: N-alkylated glycines as potent α2δ ligands.
Thompson, Lisa R; Blakemore, David C; Brugier, Delphine; Bryans, Justin S; Chu, Wai-Lam A; Maw, Graham N; Poinsard, Cedric; Rawson, David J; Warren, Andrew N.
Bioorg Med Chem Lett ; 21(12): 3764-6, 2011 Jun 15.
Article in English | MEDLINE | ID: mdl-21601457

ABSTRACT

A new series of glycine-derived ligands of the α(2)δ subunit of voltage gated calcium channels is described. Several novel compounds (7) based on (6) were prepared that possessed a potency <100 nM in the α(2)δ binding assay.


Subject(s)
Calcium Channels/drug effects , Glycine/chemical synthesis , Ligands , Alkylation , Glycine/chemistry , Glycine/pharmacology , Inhibitory Concentration 50 , Molecular Structure , Protein Subunits/chemistry , Structure-Activity Relationship
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