[Design and development of quality traceability system for circulation of Chinese herbal medicine based on blockchain and NB-IOT].

The safety of traditional Chinese medicine is an important issue of people's livelihood in China. The traceability process on the quality of traditional Chinese medicine is characterized by long duration, many links, and complex circulation process of traditional Chinese medicine, so the establishment and improvement of traceability system is key to the modernized development of traditional Chinese medicine. The circulation traceability system of Chinese medicinal materials, as an important part of traceability system for Chinese traditional medicine, is built according to the GSP standard by using the block chain technology to ensure the security of information circulation and the low energy consumption of NB-IOT technology, build a safe and reliable system with wide coverage and low cost technology, and provide safe and reliable technical support for the data collection and transmission. The Internet and cloud platform are used to collect, fill in and review the information in the circulation process of medicinal materials in real time. The third-party real-time validation is carried out by relying on the matter-linked sensing equipment to improve the accuracy of source information. The big data are fully used to build a portrait of integrity, crack down on counterfeit products, and maintain the brand image of authentic medicinal materials. System objects include medicinal materials distributors, government regulatory agencies and consumers, etc. By controlling each link of the drug circulation at different levels, the system strictly complies with the supply standard of traditional Chinese medicine, so as to form the information loop of the drug circulation and realize the whole-process supervision of the drug circulation. The system has user-friendly operation interface, comprehensive functions, simple and easy to use, with good portability and expansibility, which can promote all the people to participate in tracing the source, so as to develop a green and ecological chain for Chinese medicinal materials.

Chemical components and pharmacological action of Aconiti Radix / 中国中药杂志

Aconiti Radix is a commonly used traditional Chinese medicine( TCM) herb in clinic,with the effects in expelling wind and removing damness,warming menstruation and relieving pain. With a long medicinal history and high medicinal value,it was used for anemofrigid-damp arthralgia,arthralgia,cold hernia and anesthesia analgesia. Modern pharmacological studies have shown that Aconiti Radix has a good therapeutic effect on rheumatoid arthritis,neuropathic pain and hypertension. As a well-known toxic TCM herb,its main pharmacodynamic and toxic components are alkaloids,which can lead to neurotoxicity and cardiotoxicity while exerting anti-inflammatory,analgesic,anti-tumor and other pharmacodynamic effects. Therefore,it is often processed to reduce its toxicity or combined with Paeoniae Radix Alba and Stephaniae Tetrandrae Radix to achieve the purpose of reducing toxicity and increasing efficacy in clinic.In recent years,with the deepening of the study on the incompatibility of TCM represented by " eighteen incompatible herbs",there have been new findings about TCM incompatibility. It has been found complementary effect,rather than no obvious toxic and side effects after the combination with incompatible herbs of Aconiti Radix. To provide the basis for further study and clinical application of Aconiti Radix,this paper reviewed chemical components,pharmacological action,toxicity and compatibility of Aconiti Radix by consulting relevant literatures published in recent years at home and abroad. Meanwhile,this paper also described the relationship between chemical constituents,as well as anti-inflammatory,analgesic,anti-tumor and other pharmacological effects and toxicity.

Anti-inflammatory mechanism analysis of antirheumatic Chinese medicinal herb Aconiti Radix based on protein interaction network / 中国中药杂志

Inflammation is one of the important risk factors of rheumatic diseases. Aconiti Radix is widely used for the treatment of rheumatism, which has significant anti-inflammatory effects. However, its anti-inflammatory mechanism on molecular level is still not clear. The purpose of this study is to illuminate the anti-inflammatory mechanism of Aconiti Radix based on the protein interaction network (PIN) analysis on molecular network level. The main anti-inflammatory components (aconitine, hypaconitine and mesaconitine) were chosen in this study to obtain the targets of the components and protein-protein information though databases retrieval and construct the PIN of Aconiti Radix. By a graph theoretic clustering algorithm molecular complex detection(MCODE), 13 modules were identified and analyzed by gene ontology(GO) enrichment. The results showed that the anti-inflammatory mechanism of Aconiti Radix was mainly associated with prostanoid metabolic process and leukocyte chemotaxis mediated by chemokines. In this study, the anti-inflammatory mechanism of Aconiti Radix was elucidated systematically from molecular network level, which provided the scientific basis for the treatment of rheumatic diseases.