DEVELOPMENT OF THE POWDER FORMULAS FOR ACNE TREATMENT.

Given the large enough area of the spread of acne disease, research is needed on the development of the new versions of preparations. Cosmetics and cosmeceuticals of daily use are easy to consume as preventive remedies during mild form of the disease at an early stage. These remedies include powders, which women tend to use every day, and men, if necessary, but quite often. Powder should fit the skin, not be crumbled during the air disturbance and be kept on the face for a relatively long time, have hygroscopicity, that is, they should absorb the sweat and fat. When developing formula of similar powder, we used the available literature data on remedies using for the treatment of acne. There have been studied some technological and rheological properties of powders, such the bulk specific gravity, bulk density and natural angle of slope. Given that all parameters depend on the dispersion and a specific surface of powder, the shape of the particles and their size distributions, we used the particles of all ingredients with a size of 3 to 20 µm. The obtained powder samples are easily applied to the skin, keeping on it for at least 4-5 hours. When applied to the oily skin, there are not observed swelling of starch and coating of pores, as well as the formation of a colloidal structure of bentonite clay. For the first time, a new formula is proposed for acne treating powders containing both plant and mineral components, determining both the structural features of powder and those features that are involved in certain processes that help to increase the pharmacological effect.

Analysis of bone marrow from patients in critical condition.

The aim of the research was to determine the composition of nitrous oxide and free peroxide-radicals in bone marrow in critical condition. 27 adult patients (20 male and 7 female) in critical condition of various geneses (sepsis, insult, trauma etc.) were examined. All patients were under artificial ventilation of lungs. Morphological study of bone marrow was conducted. The research revealed toxic grains in some bone marrow punctates in critical condition. The neutrophil myelocytes were in norm (8.4+/-1.1). The quantity of metamyelocytes were increased (7.1+/-0.5-N7.7+/-0.7, P>0.5). The quantity of the mature neutrophil with a segmented nucleus were increased (34.7+/-1.4-N-36.4+/-2.1, P>0.5). The quantity of neutrophil nucleus bacillus increased (12.6+/-0.5-N -13.5+/-0.7, P>0.5). The quantity of neutrophilic promyelocyte was in norm (0.96+/-0.1-N-1.4+/-0.2, P>0.1). The quantity of lymphocytes is increased (9.0+/-0.6-N-10+/-0.7, P>0.5). The quantity of monocytes is unchanged (1.3+/-0.1- N-1.3+/-0.2, P>0.5). Basophilic normoblasts are increased in patients with critical conditions (2.0+/-0.4-N-2.1+/-0.5, P>0.5). Policromathohilic normoblasts are significantly decreased. (4.6+/-0.96-N- 2.1+/-0.6, P>0.005) The quantity of oxyphilic normoblasts is increased (6.9+/-0.7-N-9.0+/-0.4, P>0.5). Plasma cells (0.8+/-0.1-N-1.0+/-0.1) and blastic cells (0.6+/-0.04 - N-0.5+/-0.1) are in norm.