Syndromal characteristics of the combined course of chronic pancreatitis and arterial hypertension.

OBJECTIVE: The aim:To study the clinical course of chronic pancreatitis (CP) in patients with concomitant hypertension. PATIENTS AND METHODS: Materials and methods: A thorough analysis of the results of subjective and clinical and laboratory examinations of 102 patients with CP, who were hospitalized in the therapeutic department of Khust district hospital during 2017-2018 was conducted. RESULTS: Results: Takingintoaccount that the initial examination of patients was carried out during the period of exacerbation of the disease, all patients presentedwith pain syndrome (100%).The overwhelming majority of patients identified pain as permanent aching discomfort in the abdominal cavity with periodic intensification (n = 41 (40,2%), 18 patients indicated burning pain (17,6%), 30 - cutting (29,4%) ), and 13 (12,7%) experienced pain of varying nature.due to the presence of hypertension (GC) 73 (71.6%) patients complained of a headache of a paroxysmal periodic pulsating character, which was most often localized in the occipital-frontal area and was accompanied by dizziness, "flickering of flies" before the eyes, noise in the ears. Also, 14 (13,7%) patients had shortness of breath at moderate physical exercise, lower extremity edema that appeared in the afternoon and disappeared by the morning.In addition, 33 (32,4%) surveyed patients indicated a periodic heartbeat.In 18 (17,7%) patients sporadic dizziness was observed. The level of blood pressure (BP), which was established in the studied patients, corresponded to arterial hypertension of grade 1-2 (154,15 ± 9,24 / 94,53 ± 9,05 mm Hg). In terms of heart rate (HR) in the examined patients, it was 80.26 ± 10.73 beats per minute. CONCLUSION: Conclusions: According to the study, the negative impact of concomitant hypertension on the clinical course of chronic pancreatitis was established, namely: hypertension in most cases causes intensification of pain syndrome; pain syndrome in comorbid patients with cronic pancreatitis and arterial hypertension is accompanied by more pronounced manifestations of asthenisation: general weakness, lethargy;dependence of the duration of pain syndrome from the height of blood pressure and the duration of arterial hypertension was found; dyspepsia syndrome is more pronounced, varied and prolonged in patients with high blood pressure; smoking (37,3%), alcohol (19,6%), psychoemotional overload (6,9%) are common etiologic factors in comorbid patients with chronic pancreatitis and arterial hypertension; BMI results indicate the dominance of excess body mass in most comorbid patients with chronic pancreatitis and arterial hypertension.

Comparison of the effects of tofacitinib and adalimumab on transcolonoscopic ph and calprotectin levels in patients with ulcerative colitis.

OBJECTIVE: The aim: To investigate the transcolonoscopic pH-metry and calprotectin in patients with ulcerative colitis. PATIENTS AND METHODS: Materials and methods: the research included 110 patients both male and female between the ages of 18 to 75 years old, who were treated for UC of medium and severe activity, in active phase. All patients were divided into 3 groups. The first group received standard therapy (ST; n=50), the second group received adalimumab (ADA; n=32), and the third group was treated with tofacitinib (TOF; n=28). The control group consisted of healthy individuals between the ages of 18 and 65 years old. RESULTS: Results: UC patients had lower pH levels in all sections of the large intestine, compared to the control group (р<0,05). Calprotectin level is a better predictor of the course of the disease. CONCLUSION: Conclusions:Tofacitinib, compared to adalimumab and budesonide, has better influence on clinical, endoscopic and laboratory parameters of UC.