[Evaluation of the stability and prognostic significance of identification of various risk factors of ischemic heart disease in 50 to 59-year-old men]. / Otsenka stabil'nosti i prognosticheskoi znachimosti vyiavleniia nekotorykh faktorov riska ishemicheskoi bolezni serdtsa u muzhchin 50--59 let.

The authors present the data on the prevalence of coronary heart disease (CHD) and its risk factors, on the incidence of new cases of CHD and the associated mortality in the unorganized population of 50-59-year-old men of Moscow as well as findings on the natural variability of risk factors obtained over six years in a follow-up study. The relationship between the CHD incidence on the one hand and the baseline arterial pressure levels, excessive body weight and smoking habit on the other is evaluated. Arterial hypertension is shown to be the most prognostic risk factor of CHD in the unifactorial analysis.

[Major results of a long-term prospective study of a male population]. / Osnovnye rezul'taty mnogoletnego prospektivnogo nabliudeniia za muzhskoi populiatsiei.

The results of a prospective study of a Moscow population of males aged 50-59, represented in 4 independent samples (each numbering 500 subjects), are reported. Two examinations were conducted at a 6.5-year interval, and mortality was reviewed in the examined population. High incidence of coronary heart disease (CHD) and its risk factors was established at first screening, and increased further during the next decade. The need for a differential approach to the assessment of CHD risk factors and high mortality rates, and also to the planning of preventive programs with regard to age, presence of CHD and its risk factors, is emphasized.

[Results of a carbohydrate tolerance study in prospective epidemiological research on ischemic heart disease]. / Rezul'taty izucheniia tolerantnosti k uglevodam v prospektivnom épidemiologicheskom issledovanii IBS.

There are presented the results of a prospective study aimed at establishing the incidence of impaired carbohydrate tolerance in a nonorganized population of middle-aged males, which in a 6.5-year follow-up accounted for 42.2 and 40.3%, respectively. The incidence of diabetes mellitus increased drastically with age (3.1% and 9.8% in 50-54 and 60-64 year-old men, respectively). Men with borderline impaired carbohydrate tolerance combined with glucosuria require the most thorough dispensary follow-up, for they were found to develop diabetes mellitus in 6.3% of cases during the following 6.5 years.

[New cases of ischemic heart disease and the dynamics of its various forms in a multiyear prospective study of men 50-59 years old]. / Novye sluchai ishemicheskoi bolezni serdtsa i dinamika ee razlichnykh form pri mnogoletnem prospektivnom issledovanii muzhchin 50-59 let.

A report of a follow up study on a selected male population aged 50-59 from one of the central districts of Moscow is presented. The initial check-up found ischaemic heart disease (IHD) in 18.4% of cases, and 61/2 years later in 27.7% (p less than 0.01). The frequency of new cases of IHD appearing was 17.6%, in older age group (55-59) it was 2.8% higher, than in the younger group (50-54). In the older male group during the observation period death rate from IHD was encountered more frequently (6.1%), than in the younger group (1.6%). The number of new cases of myocardial infarction found during the second investigation, and deaths from acute coronary insufficiency in both age groups was practically the same: 8.2% among the total population. General number of new cases of IHD in 61/2 years, determined with mortality from IHD was 18.4%, or 2.8% per year. The stability of the more severe manifestations of IHD is shown. It is noted that atypical forms of angina pectoris and "doubtful" ischaemic changes on ECG may be regarded as "precursors" of IHD and persons with such signs require further follow up.

[Assessment of ischemic heart disease risk factors in relation to mortality (data from a multiyear prospective study in Moscow)]. / Otsenka faktorov riska ishemicheskoi bolezni serdtsa v otnoshenii smertnosti (dannye mnogoletnego prospektivnogo issledovaniia v Moskve).

Seven-year prospective study of mortality among the selected male population born in 1909--1918 showed that in some cases the region of high death risk is noted not only in the upper but also in the lower decyls and that of low risk in the center of the distribution of some of the ischemic heart disease (IHD) risk factors. Differentiation of the whole population into groups of individuals with IHD and those without IHD according to the findings of the initial examination enabled the authors to distinguish various tendencies of changes in the death risk depending on the arterial pressure levels and the lipid content. In prolongation of the period of observation of the population it is necessary to take into consideration the variability of the risk factors as well as the development of new cases with IHD in the period after the first examination.

[Multiyear prospective study of ischemic heart disease among a selected male population from one of the districts of Moscow. A comparison of the data from repeat examinations of the chosen population after 6 1/2 years]. / Mnogoletnee prospektivnoe issledovanie ishemicheskoi bolezni serdtsa sredi vyborochnogo muzhskogo naseleniia odnogo iz raionov Moskvy. Sravnenie dannykh povtornykh obsledovanii izbrannoi populiatsii cherez 6 1/2 let.

The findings of a prospective follow-up of a selective male population whose ages ranged from 50 to 59 years are discussed. Two one-stage examinations were conducted at an interval of 6 1/2 years. A marked increase in the incidence of various forms of ischemic heart disease and its risk factors was noted. Growth of the entropy of the distribution of the forms of ischemic heart disease, ECG changes, and risk factors was also revealed, which reflected the unidirectional process of ageing of the population associated with the accumulation of "pathology" with time.

[Risk factors in ischemic heart disease (arterial hypertension and hypercholesterolemia) and population age]. / Faktory riska ishemicheskoi bolezni serdtsa (arterial'naia gipertoniia i giperkholesterinemiia) i vozrast populiatsii.

Comparative data of a 40% randomized screening of the male population in Moscow aged 50-59 (2000 males), a 5% randomized sample (392 males) aged 40-49, as well as 1631 males aged 40-49, subjected to prophylactic examinations are presented. The changes of the analyzed risk factors proved to be more pronounced in subjects aged 50-59, while significance of individual risk factors as regards the prevalence of ischemic heart disease (IHD) decreases with age. The subjects undergoing prophylactic examination represent a more risk population group in respect to the prevalence of IHD risk factors as compared with the randomized sample.

[Determination of carbohydrate tolerance disorders in mass epidemiologic studies]. / Opredelenie narushennoi tolerantnosti k uglevodam pri massovykh épidemiologicheskikh issledovaniiakh.

The authors evaluated the informativeness of both the individual sugar curve levels and their combinations for determination of disturbed carbohydrate tolerance. It appeared that the most informative one was blood sugar level 1 hour after the glucose load, and the least--on fasting stomach. Regression equations permitting to restore the sugar curve in the presence of incomplete data with no lesser precision than the biological reproducibility were obtained. Due to the fact that statistical connection was detected between the individual levels a possibility of increasing the sensitivity of the method of disturbed carbohydrate tolerance determination (particularly in using the blood sugar level on fasting stomach and 2 hours after the glucose load) was revealed.

[Relationship between certain risk factors, age and ischemic heart disease according to simultaneous epidemiological study]. / Sviaz' nekotorykh faktorov riska s vozrastom i ischemicheskoi bolezn' iu serdtsa v odnomomentnom epidemiologicheskom issledovanii.

The measure of the difference according to certain risk factors and their combination in population subgroups differing in age and health (with or without ischemic heart disease) is appraised. The lowest measures of difference were revealed between elderly subgroups (55--59 years) with or without ischemic heart disease, as well as between young and middle-age subgroups with ischemic heart disease. Risk factors associated with lipid metabolism and also those such as the blood sugar level on a fasting stomach and the blood fibrinogen level carried more information when subgroups with ischemic heart disease and those without it were compared, while factors associated with arterial pressure proved more informative in comparison between subgroups of elderly and young individuals. When all the subgroup pairs were considered, significance proved to be highest for the levels of pulse, systolic pressure and blood serum triglycerides and lowest for the levels of blood fibrinogen and blood sugar on a fasting stomach.

[Prevalence of ischemic heart disease depending on the extent of manifestation of certain risk factors]. / Rasprostranennost' ishemicheskoi bolezni serdtsa v zavisimosti ot vyrazhennosti nekotorykh faktorov riska

A comparative assessment is presented for the significance of some risk factors (systolic and diastolic pressures, blood serum cholesterol and triglycerides, fasting blood sugar level and blood fibrinogen level) for the spreading of ischaemic heart disease with reference to their severity. When the method of parametric discriminative analysis was used, most of the examined indices displayed a growing extent of ischaemic heart disease from the lower values towards the higher ones, and a decreasing importance of the factor with the growing age. The multidimentional analysis of the spreading of ischaemic heart disease illustrates its increasing spreading along with the accumulation of the amount of some risk factors. These data proved the necessity of a differentiated approach to the study of preventive measures in different age groups with certain risk factors.