ABSTRACT
INTRODUCTION: The evolution of the incidence of type 1 diabetes (T1D) in all groups is controversial. Our objective is to study the incidence from 2009 to 2020, based on the Type 1 Diabetes Registry of Navarra, and to analyze the clinical presentation as diabetic ketoacidosis (DKA), and HbA1c at onset. MATERIALS AND METHODS: Descriptive study of all cases diagnosed as T1D and included in the Population Registry of T1D of Navarra in the period 1/1/2009 to 12/31/2020. Data are obtained from primary and secondary sources with an ascertainment rate of 96%. Incidence rates are expressed per 100,000 person-years of risk, by age group and sex. Likewise, a descriptive analysis of the HbA1c and DKA at diagnosis of each patient is performed. RESULTS: 627 new cases are registered, which represents an incidence of 8.1 (10 in men, 6.3 in women), without differences throughout the analyzed period. The group with the highest incidence is the 10-14 years old children (27.8), followed by that of 5-9 years old (20.6). The incidence in people older than 15 years is 5.8. Twenty six percent of patients present DKA at onset. The global mean of HbA1c is 11.6%, without changes throughout the studied period. CONCLUSIONS: The population registry of T1D of Navarra shows a stabilization in the incidence of T1D at all ages in the 2009-2020 period. The percentage of presentation as severe forms is high, even in adulthood.
Subject(s)
Diabetes Mellitus, Type 1 , Diabetic Ketoacidosis , Male , Child , Humans , Female , Adolescent , Child, Preschool , Diabetes Mellitus, Type 1/complications , Incidence , Glycated Hemoglobin , Diabetic Ketoacidosis/epidemiologyABSTRACT
Objective: To determine trends in the incidence of type 1 diabetes in Navarre (Spain) between 1975 and 2012 by age and sex. Patients and methods: The study population comprised residents of Navarre under 15 years of age. A Poisson regression model was fitted to analyze changes in the incidence over time, adjusted by year of diagnosis, age group and sex. Results: A total of 494 patients were registered, representing an adjusted incidence rate of 13.2/100,000 person-years. The annual relative increase in the incidence rate was 3.7%. The highest incidence was found in the group aged 10-14 years. The incidence among boys aged 10-14 tended to be higher than that in girls of the same age. Conclusions: Since the year 2000, the incidence of type 1 diabetes among persons younger than 15 years in Navarre has been very high and has quadrupled over the last four decades (AU)
Objetivo: Determinar la tendencia en la incidencia de diabetes tipo 1 en Navarra entre 1975 y 2012 por edad y sexo. Pacientes y métodos: La población objeto de estudio comprende a los residentes en Navarra menores de 15 años de edad. Para analizar la evolución de la incidencia a lo largo del tiempo, se ha utilizado un modelo de regresión de Poisson ajustado por año de diagnóstico, grupo de edad y sexo. Resultados: Se han diagnosticado 494 pacientes, lo que supone una incidencia ajustada de 13,2/100.000 personas-año. El incremento relativo anual en la tasa de incidencia ha sido del 3,7%. El grupo de edad con mayor incidencia fue el de 10 a 14 años. En este mismo grupo, la incidencia en niños tiende a ser mayor que en niñas. Conclusiones: Desde el año 2000, la incidencia de diabetes tipo 1 en menores de 15 años, en Navarra, es muy alta y se ha cuadriplicado en las últimas cuatro décadas (AU)
Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Diabetes Mellitus, Type 1/epidemiology , Age and Sex Distribution , Genetic Predisposition to Disease , Risk FactorsABSTRACT
OBJECTIVE: To determine trends in the incidence of type 1 diabetes in Navarre (Spain) between 1975 and 2012 by age and sex. PATIENTS AND METHODS: The study population comprised residents of Navarre under 15 years of age. A Poisson regression model was fitted to analyze changes in the incidence over time, adjusted by year of diagnosis, age group and sex. RESULTS: A total of 494 patients were registered, representing an adjusted incidence rate of 13.2/100,000 person-years. The annual relative increase in the incidence rate was 3.7%. The highest incidence was found in the group aged 10-14 years. The incidence among boys aged 10-14 tended to be higher than that in girls of the same age. CONCLUSIONS: Since the year 2000, the incidence of type 1 diabetes among persons younger than 15 years in Navarre has been very high and has quadrupled over the last four decades.
