Putting a human in the loop: Increasing uptake, but decreasing accuracy of automated decision-making.

Automated decision-making gains traction, prompting discussions on regulation with calls for human oversight. Understanding how human involvement affects the acceptance of algorithmic recommendations and the accuracy of resulting decisions is vital. In an online experiment (N = 292), for a prediction task, participants choose a recommendation stemming either from an algorithm or another participant. In a between-subject design, we varied if the prediction was delegated completely or if the recommendation could be adjusted. 66% of times, participants preferred to delegate the decision to an algorithm over an equally accurate human. The preference for an algorithm increased by 7 percentage points if participants could monitor and adjust the recommendations. Participants followed algorithmic recommendations more closely. Importantly, they were less likely to intervene with the least accurate recommendations. Hence, in our experiment the human-in-the-loop design increases the uptake but decreases the accuracy of the decisions.

Long-term effects of oil contamination on soil quality and metabolic function.

Widespread soil contamination with oil and the toxicity of petroleum hydrocarbons to soil biota make it extremely important to study microbial responses to oil stress. Soil metabolites reflect the main metabolic pathways in the soil microbial community. The examination of changes in the soil metabolic profile and metabolic function is essential for a better understanding of the nature of the pollution and restoration of the disturbed soils. The present study aimed to assess the long-term effect of oil on the ecological state of the soil, evaluate quantitative and qualitative differences in metabolite composition between soil contaminated with oil and non-contaminated soil, and reveal biologically active metabolites that are related to oil contamination and can be used for contamination assessment. A long-term field experiment was conducted to examine the effects of various oil concentrations on the biochemical properties and metabolic profile of the soil. Podzolic soil contaminated with oil demonstrated the long-term inhibition of soil biological activity and vegetation. Oil affected the metabolic activity of soil fungi increasing the production of toxic metabolites. A metabolomic approach was employed to determine soil metabolites. The metabolite profile was found to vary greatly between oil-contaminated and non-contaminated soils. Carbohydrates had the largest number of metabolites negatively affected by oil, while the content of organic acids, phenolic compounds, and terpenoids was mainly increased in oil-contaminated soil. The evaluation of the long-term impact of oil on microbial metabolism can make a valuable contribution to the assessment of soil quality and the activity of soil microorganisms being under stress from oil pollution. The results contribute to a further understanding of the role of microorganisms in the ecological functions of contaminated soil, which can be useful in the development of rehabilitation strategies for disturbed sites.

Mathematical modeling of microscale biology: Ion pairing, spatially varying permittivity, and Born energy in glycosaminoglycan brushes.

Biological macromolecules including nucleic acids, proteins, and glycosaminoglycans are typically anionic and can span domains of up to hundreds of nanometers and even micron length scales. The structures exist in crowded environments that are dominated by multivalent electrostatic interactions that can be modeled using mean-field continuum approaches that represent underlying molecular nanoscale biophysics. We develop such models for glycosaminoglycan brushes using steady state modified Poisson-Boltzmann models that incorporate important ion-specific (Hofmeister) effects. The results quantify how electroneutrality is attained through ion electrophoresis, spatially-varying permittivity hydration forces, and ion-specific pairing. Brush-salt interfacial profiles of the electrostatic potential as well as bound and unbound ions are characterized for imposed jump conditions across the interface. The models should be applicable to many intrinsically-disordered biophysical environments and are anticipated to provide insight into the design and development of therapeutics and drug-delivery vehicles to improve human health.

Lumped parameter models for two-ventricle and healthy and failing extracardiac Fontan circulations.

Fontan circulations are surgical strategies to treat infants born with single ventricle physiology. Clinical and mathematical definitions of Fontan failure are lacking, and understanding is needed of parameters indicative of declining physiologies. Our objective is to develop lumped parameter models of two-ventricle and single-ventricle circulations. These models, their mathematical formulations and a proof of existence of periodic solutions are presented. Sensitivity analyses are performed to identify key parameters. Systemic venous and systolic left ventricular compliances and systemic capillary and pulmonary venous resistances are identified as key parameters. Our models serve as a framework to study the differences between two-ventricle and single-ventricle physiologies and healthy and failing Fontan circulations.

In Vivo Activity of Repurposed Amodiaquine as a Host-Targeting Therapy for the Treatment of Anthrax.

Anthrax is caused by Bacillus anthracis and can result in nearly 100% mortality due in part to anthrax toxin. Antimalarial amodiaquine (AQ) acts as a host-oriented inhibitor of anthrax toxin endocytosis. Here, we determined the pharmacokinetics and safety of AQ in mice, rabbits, and humans as well as the efficacy in the fly, mouse, and rabbit models of anthrax infection. In the therapeutic-intervention studies, AQ nearly doubled the survival of mice infected subcutaneously with a B. anthracis dose lethal to 60% of the animals (LD60). In rabbits challenged with 200 LD50 of aerosolized B. anthracis, AQ as a monotherapy delayed death, doubled the survival rate of infected animals that received a suboptimal amount of antibacterial levofloxacin, and reduced bacteremia and toxemia in tissues. Surprisingly, the anthrax efficacy of AQ relies on an additional host macrophage-directed antibacterial mechanism, which was validated in the toxin-independent Drosophila model of Bacillus infection. Lastly, a systematic literature review of the safety and pharmacokinetics of AQ in humans from over 2 000 published articles revealed that AQ is likely safe when taken as prescribed, and its pharmacokinetics predicts anthrax efficacy in humans. Our results support the future examination of AQ as adjunctive therapy for the prophylactic anthrax treatment.

Bioaugmentation: possible scenarios due to application of bacterial preparations for remediation of oil-contaminated soil.

Although bioaugmentation is known as effective and environmentally friendly method increasing removal of hydrocarbons from oil-contaminated soil, it sometimes fails in soil restoration and disturbs the ecological state of soil. We studied possible scenarios of the introduction of oil-degrading bacteria into oil-contaminated podzolic soil assessing the environmental safety of different bacterial preparations in a long-term field experiment. Integral indicators characterizing the state of biocenosis included biological activity of soil and aboveground biomass of grasses. It has been established that bacterial preparations can have both positive and negative effects on the ecological state of soil and oil biodegradation. Of the five bacterial preparations studied, one had a pronounced positive effect on soil biological activity and oil mineralization processes. Two preparations did not accelerate oil biodegradation and were characterized by a weaker positive effect or even a lack of influence. Two more bacterial preparations had a significant negative impact on soil biological properties. These preparations slowed oil mineralization in soil. Both positive and negative effects of bacterial preparations were observed only during the first two years after their application. All preparations were not effective during the latter stages of long-term remediation processes. The results indicate that successful application of bioaugmentation for the restoration of oil-contaminated soil requires testing of environmental safety of bacterial preparations in a long-term field experiments prior to any treatment processes.

Feshbach resonance management of Bose-Einstein condensates in optical lattices.

We analyze gap solitons in trapped Bose-Einstein condensates (BECs) in optical lattice potentials under Feshbach resonance management. Starting with an averaged Gross-Pitaevsky equation with a periodic potential, we employ an envelope-wave approximation to derive coupled-mode equations describing the slow BEC dynamics in the first spectral gap of the optical lattice. We construct exact analytical formulas describing gap soliton solutions and examine their spectral stability using the Chebyshev interpolation method. We show that these gap solitons are unstable far from the threshold of local bifurcation and that the instability results in the distortion of their shape. We also predict the threshold of the power of gap solitons near the local bifurcation limit.