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Bioorg Khim ; 37(5): 685-9, 2011.
Article in Russian | MEDLINE | ID: mdl-22332365

ABSTRACT

The resolution of the racemic ortho-isobornylphenol into enantiomers via diastereomeric camphanates was carried out. The absolute configuration ofchiral centers of synthesized compounds was established by the single crystal X-ray diffraction method. Antioxidant activity and membrane protective properties of individual enantiomers were studied on the model of H2O2-induced hemolysis of red blood cells.


Subject(s)
Antioxidants/chemistry , Antioxidants/pharmacology , Camphanes/chemical synthesis , Camphanes/pharmacology , Phenols/chemistry , Phenols/pharmacology , Animals , Cell Membrane/drug effects , Crystallography, X-Ray , Erythrocytes/drug effects , Hemoglobins/chemistry , Hemolysis , Hydrogen Peroxide/chemistry , Mice , Oxidation-Reduction , Stereoisomerism
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